Nanoceria Suppresses Multiple Low Doses of Streptozotocin-Induced Type 1 Diabetes by Inhibition of Nrf2/NF-κB Pathway and Reduction of Apoptosis

Abstract

Considered together, our data establishes the antidiabetic potential of NC which may become a novel strategy to combat T1DM in the near future.

Crocin, an active constituent of Crocus sativus ameliorates cerulein induced pancreatic inflammation and oxidative stress

“…Immunohistochemistry was performed on 5-μm thick sections after deparaffinisation as per an earlier described method (Khurana, Tekula, & Godugu, 2018). The sections were coincubated with primary rabbit polyclonal IgG antibodies (Nitrotyrosine, Nrf-2, IL-6, NF-κB) (Santa Cruz Biotechnologies, Santa Cruz, CA) (1:100 dilution) overnight, probed with secondary antibody.…”

Modulation of cerulein‐induced pancreatic inflammation by hydroalcoholic extract of curry leaf (Murraya koenigii)

“…In addition, detailed toxicological studies are necessary to decide the clinical future of this novel plant and its various active constituents as safety is a critical concern during clinical development of plant‐based medicines (Izzo, Hoon‐Kim, Radhakrishnan, & Williamson, ). In addition, physiological and biopharmaceutical parameters are often the bottleneck in the clinical translation of plant‐based medicines, which may be addressed by using various novel formulation‐based strategies (Bale, Khurana, Reddy, Singh, & Godugu, ; Godugu, Kumari, & Khurana, ; Khurana et al, ; Khurana, Saifi, & Godugu, ; Khurana, Tekula, Saifi, Venkatesh, & Godugu, ).…”

“…Immunohistochemistry was performed on 5 μm thick sections after deparaffinisation, as per our previously optimized protocol (Godugu, Doddapaneni, & Singh, ; Khurana, Tekula, & Godugu, ; Tekula et al, ). Sections were subjected to dehydration in graded alcohol followed by washing with Tris buffered saline (TBS) and incubation of the sections with proteinase‐K at 37°C for 20 min.…”

Withaferin A reverses bile duct ligation‐induced liver fibrosis by modulating extracellular matrix deposition: Role of LOXL2/Snail1, vimentin, and NFκB signaling

“…Histopathological examination of the mouse tissue sample (liver) from each study group was carried out to observe and compare the histological changes . Thin sections of 5 μm were used for H&E, picrosirius, and Masson's trichrome staining as per standard protocols .…”

“…Histopathological examination of the mouse tissue sample (liver) from each study group was carried out to observe and compare the histological changes. 25,26 Thin sections of 5 μm were used for H&E, picrosirius, and Masson's trichrome staining as per standard protocols. 27,28 Modified Knodell histology activity index grading was adopted for necroinflammatory scoring of H&E stained sections (no necrosis = 0, one or less necrotic foci per ×10 objective = 1, two to four foci per ×10 objective = 2, five to ten foci per ×10 objective = 3, >10 foci per ×10 objective = 4; no inflammation = 0, mild inflammation around some or all portal areas = 1, moderate inflammation = 2, marked inflammation = 3, marked inflammation around all portal areas = 4).…”