Nanocellulose: A mini-review on types and use in drug delivery systems

Raghav, Neera; Sharma, Manishita R.; Kennedy, John F.

doi:10.1016/j.carpta.2020.100031

Cited by 82 publications

(67 citation statements)

References 143 publications

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“…Depending on the treatment carried out, two main types of nanocellulose structures, nanofibers or nanocrystals, are mainly obtained from the cellulose extracted in the pretreatments [20]. Most of the bibliography contemplates the extraction of cellulose and its purification based mainly on acid treatments.…”

Section: Nanocellulose Productsmentioning

confidence: 99%

“…Changes on nanocellulose surface must be carried out to link drugs, non-ionic chemicals with hydrophobic character, to the nanopolymer. Mechanisms of sulfonation, silylation, esterification or carboxylation as well as cationic surfactants can be used to modify the negative charge of nanocellulose [20]; thus, enhancing its hydrophobic character to facilitate bonds with drugs can control its slow release according to recent research [108]. Hydrogels are capable of accommodating different biofactors that can be released by varying the physicochemical properties of the three dimensional network, for example, modifying the crosslinking density.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

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Nanocellulose from Agricultural Wastes: Products and Applications—A Review

et al. 2021

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The isolation of nanocellulose from different agricultural residues is becoming an important research field due to its versatile applications. This work collects different production processes, including conditioning steps, pretreatments, bleaching processes and finally purification for the production of nanocellulose in its main types of morphologies: cellulose nanofiber (CNF) and cellulose nanocrystal (CNC). This review highlights the importance of agricultural wastes in the production of nanocellulose in order to reduce environmental impact, use of fossil resources, guarantee sustainable economic growth and close the circle of resource use. Finally, the possible applications of the nanocellulose obtained as a new source of raw material in various industrial fields are discussed.

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Section: Nanocellulose Productsmentioning

confidence: 99%

Section: Biomedical Applicationsmentioning

confidence: 99%

Nanocellulose from Agricultural Wastes: Products and Applications—A Review

et al. 2021

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“…CNCs are attractive for use as a filler in the hydrogel matrix due to their renewability, abundance, cytocompatibility, and excellent mechanical properties [21,22]. The presence of hydroxyl groups on the surface is responsible for reactivity, hydrophilicity, and the cellulose's physical properties [23,24]. Those traits support the use of cellulose-based hydrogel in water treatment [25].…”

Section: Introductionmentioning

confidence: 99%

Engineered Superabsorbent Nanocomposite Reinforced with Cellulose Nanocrystals for Remediation of Basic Dyes: Isotherm, Kinetic, and Thermodynamic Studies

2022

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In this study, cellulose nanocrystals (CNCs) were produced from pea peels by acid hydrolysis to be used with pectin and acrylic acid (AAc) to form Pectin-PAAc/CNC nanocomposite by γ-irradiation. The structure, morphology, and properties of the nanocomposite were investigated using Fourier transform infrared spectroscopy (FTIR) and atomic force microscopy (AFM) techniques. The nanocomposite hydrogel was used for the removal of methylene blue dye (MB) from wastewater. The results revealed that the presence of CNCs in the polymeric matrix enhances the swelling and adsorption properties of Pectin-PAAc/CNC. The optimum adsorbate concentration is 70 mg/L. The kinetic experimental data were fit by pseudo-first-order (PFO), pseudo-second-order (PSO), and Avrami (Avr) kinetic models. It was found that the kinetic models fit the adsorption of MB well where the correlation coefficients of all kinetic models are higher than 0.97. The Avr kinetic model has the lowest ∆qe (normalized standard deviation) value, making it the most suitable one for describing the adsorption kinetics. The adsorption isotherm of MB by Pectin-PAAc follows the Brouers–Sotolongo model while that by Pectin-PAAc/CNC follows the Langmuir isotherm model. The negative values of ∆G confirmed the spontaneous nature of adsorption, and the positive value of ∆H indicated the endothermic nature of the adsorption.

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“…Cellulose-based materials advanced drug delivery [51,[223][224][225][226][227]. They can be conjugated with nanomaterials such as magnetic nanoparticles (MNPs) to offer multifunctional applications [228].…”

Section: Drug and Gene Delivery Using Cellulose-based Materialsmentioning

confidence: 99%

A Review on Cellulose-based Materials for Biomedicine

Abdelhamid¹,

Mathew²

2022

Preprint

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There are various biomaterials in nature, but none fulfills all the requirements. Cellulose, eco-friendly material-based biopolymers, have been advanced biomedicine to satisfy most market demand and circumvent many ecological concerns. This review aims to present an overview of the state of the art in cellulose's knowledge and technical biomedical applications. It included an extensive bibliography of recent research findings for fundamental and applied investigations. The chemical structure of cellulose allows modifications and simple conjugation with several materials, including nanoparticles, without tedious efforts. Cellulose-based materials were used for biomedicine applications such as antibacterial agents, antifouling, wound healing, drug delivery, tissue engineering, and bone regeneration. They advanced the applications to be cheap, biocompatible, biodegradable, easy for shaping and processing into different forms, with suitable chemical, mechanical and physical properties.

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Nanocellulose: A mini-review on types and use in drug delivery systems

Cited by 82 publications

References 143 publications

Nanocellulose from Agricultural Wastes: Products and Applications—A Review

Nanocellulose from Agricultural Wastes: Products and Applications—A Review

Engineered Superabsorbent Nanocomposite Reinforced with Cellulose Nanocrystals for Remediation of Basic Dyes: Isotherm, Kinetic, and Thermodynamic Studies

A Review on Cellulose-based Materials for Biomedicine

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