Nanocarriers for Delivery of Herbal Based Drugs in Breast Cancer - An Overview

Wani, Kirtee; Tarawadi, Kirtan; Kaul-Ghanekar, Ruchika

doi:10.4028/www.scientific.net/jnanor.34.29

Cited by 11 publications

(5 citation statements)

References 47 publications

(46 reference statements)

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“…Breast cancer (BCa) is the second leading cause of morbidity and mortality in women [1][2][3][4][5]. Furthermore, triple-negative breast cancer (TNBC) presents considerable therapeutic challenges due to disease heterogeneity, absence of established therapeutic targets, aggressive metastatic potential with higher rate of distant recurrence, and poor prognosis [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, DNA binding, topoisomerase inhibition, and apoptosis induction studies of a novel cobalt(III) complex with a thiosemicarbazone ligand

Beebe¹,

Celestine

Bullock

et al. 2020

Journal of Inorganic Biochemistry

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× 10 5 and 1.6 × 10 4 M −1 , respectively). Topoisomerase inhibition assays and cleavage studies proved that complex 4 was an efficient catalytic inhibitor of human topoisomerases I and IIα. Based upon the results obtained from the 3-(4,5-dimethylthiazol-2-yl)-5-(3carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay on 4T1-luc metastatic mammary breast cancer cells (IC 50 = 34.4 ± 5.2 μM when compared to IC 50 = 13.75 ± 1.08 μM for the control, cisplatin), further investigations into the molecular events initiated by exposure to complex 4 were investigated. Studies have shown that complex 4 activated both the apoptotic and autophagic signaling pathways in addition to causing dissipation of the mitochondrial membrane potential (ΔΨ m). Furthermore, activation of cysteine-aspartic proteases3 (caspase 3) in a time-and concentration-dependent manner coupled with the ΔΨ m , studies implicated the intrinsic apoptotic pathway as the major regulator of cell death mechanism.

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, DNA binding, topoisomerase inhibition, and apoptosis induction studies of a novel cobalt(III) complex with a thiosemicarbazone ligand

Beebe¹,

Celestine

Bullock

et al. 2020

Journal of Inorganic Biochemistry

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“…As mentioned in the previous sections, nanochemotherapeutic agents exhibit improved bioavailability, enhanced bioactivity, and stability with minimal systemic toxic effects. 142 Moreover, surface modification of these nanocarriers with various ligands has been found to improve the targeting of bioactive agents to a cancer cell and then increase therapeutic efficacy and reduce toxic effects. Among these, CPPs/TTPs provide a highly promising approach for the intracellular delivery of anticancer drugs.…”

Section: Application Of Cpp/ttp Nanocarriers For Herb-based Anticancementioning

confidence: 99%

Tumor-targeting delivery of herb-based drugs with cell-penetrating/tumor-targeting peptide-modified nanocarriers

Kebebe¹,

Liu²,

Wu³

et al. 2018

IJN

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Cancer has become one of the leading causes of mortality globally. The major challenges of conventional cancer therapy are the failure of most chemotherapeutic agents to accumulate selectively in tumor cells and their severe systemic side effects. In the past three decades, a number of drug delivery approaches have been discovered to overwhelm the obstacles. Among these, nanocarriers have gained much attention for their excellent and efficient drug delivery systems to improve specific tissue/organ/cell targeting. In order to enhance targeting efficiency further and reduce limitations of nanocarriers, nanoparticle surfaces are functionalized with different ligands. Several kinds of ligand-modified nanomedicines have been reported. Cell-penetrating peptides (CPPs) are promising ligands, attracting the attention of researchers due to their efficiency to transport bioactive molecules intracellularly. However, their lack of specificity and in vivo degradation led to the development of newer types of CPP. Currently, activable CPP and tumor-targeting peptide (TTP)-modified nanocarriers have shown dramatically superior cellular specific uptake, cytotoxicity, and tumor growth inhibition. In this review, we discuss recent advances in tumor-targeting strategies using CPPs and their limitations in tumor delivery systems. Special emphasis is given to activable CPPs and TTPs. Finally, we address the application of CPPs and/or TTPs in the delivery of plant-derived chemotherapeutic agents.

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“…Dendrimers can be tagged with specific antibodies or ligands for their site-specific targeting especially as nanocarriers for anticancer therapeutic drugs (Wani et al, 2015). Madaan et al (2016) investigated the efficacy of quercetin-loaded polyamidoamine (PAMAM) dendrimers for oral administration and stated them to be beneficial in resolving drawbacks of oral administration of quercetin.…”

Section: Dendrimersmentioning

confidence: 99%

Current Knowledge on Nanodelivery Systems and Their Beneficial Applications in Enhancing the Efficacy of Herbal Drugs

Ambwani¹,

Tandon²,

Ambwani³

et al. 2018

JEBAS

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Herbal remedies have been extensively used since times immemorial throughout the world. These have wide acceptability due to their time-tested therapeutic values and minimal side effects in contrast to modern allopathic medicines. Commonly, the herbal medicines are available in the form of crude extracts prepared in different solvent systems which might not only need large dose administration but also could be less effective in the form of conventional formulations. Moreover, available phytoformulations do not have the ability for specific tissue target delivery in case of different chronic diseases. Oral administration of these herbal formulations is subjected to adverse pH, enzymatic degradation and ultimately poor gut absorption and bioavailability. With the advancements in biotechnology, genomics, and combinatorial chemistry, new, more potent and specific drug delivery systems have been envisaged during the last few decades. Constraints associated with conventional phytopharmaceuticals have been improved by designing and using -Nano Delivery Systems‖ (NDS). The foremost aim of NDS is to provide sustained drug release, site-specific action, and improved patient's compliance. Nano herbal medicines can be used to target them to the specific site in the body which improves their selectivity, solubility, delivery, safety, effectiveness and thus reduces the need for

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Nanocarriers for Delivery of Herbal Based Drugs in Breast Cancer - An Overview

Cited by 11 publications

References 47 publications

Synthesis, characterization, DNA binding, topoisomerase inhibition, and apoptosis induction studies of a novel cobalt(III) complex with a thiosemicarbazone ligand

Synthesis, characterization, DNA binding, topoisomerase inhibition, and apoptosis induction studies of a novel cobalt(III) complex with a thiosemicarbazone ligand

Tumor-targeting delivery of herb-based drugs with cell-penetrating/tumor-targeting peptide-modified nanocarriers

Current Knowledge on Nanodelivery Systems and Their Beneficial Applications in Enhancing the Efficacy of Herbal Drugs

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