Nanocarrier based approaches for targeting breast cancer stem cells

Pindiprolu, Sai Kiran S. S.; Chintamaneni, Pavan Kumar; Karri, Veera Venkata Satyanarayana Reddy

doi:10.1080/21691401.2017.1366337

Cited by 27 publications

(13 citation statements)

References 145 publications

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“…Therefore, the cytotoxicity of the synthesised MWCNTs at concentration of 80 µg/mL ascribed to the intracellular release from FA‐EDA‐MWCNTs‐DOX which results higher uptake by cells wherein directly permits to the nucleus of tumour cells. The obtained results are in line with the reported data [36]. In addition the outcome displayed that the zeta potential of conjugate FA‐EDA‐MWCNTs‐DOX did not showed symbolic change during the time of examination.…”

Section: Resultssupporting

confidence: 91%

Facile synthesis of multi‐walled carbon nanotube via folic acid grafted nanoparticle for precise delivery of doxorubicin

Uttekar¹,

Lakade²,

Beldar³

et al. 2019

IET nanobiotechnol.

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The motive of work was to develop a multi-walled carbon nanoplatform through facile method for transportation of potential anticancer drug doxorubicin (DOX). Folic acid (FA)-ethylene diamine (EDA) anchored and acid functionalised MWCNTs were covalently grafted with DOX via π-π stacking interaction. The resultant composite was corroborated by 1 H NMR, FTIR, XRD, EDX, SEM, and DSC study. The drug entrapment efficiency of FA-conjugated MWCNT was found high and stability study revealed its suitability in biological system. FA-EDA-MWCNTs-DOX conjugate demonstrated a significant in vitro anticancer activity on human breast cancer MCF-7 cells. MTT study revealed the lesser cytotoxicity of folate-conjugated MWCNTs. The obtained results demonstrated the targeting specificity of FA-conjugate via overexpressed folate receptor deemed greater scientific value to overcome multidrug protection during cancer therapy. The proposed strategy is a gentle contribution towards development of biocompatible targeted drug delivery and offers potential to address the current challenges in cancer therapy.

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Section: Resultssupporting

confidence: 91%

Facile synthesis of multi‐walled carbon nanotube via folic acid grafted nanoparticle for precise delivery of doxorubicin

Uttekar¹,

Lakade²,

Beldar³

et al. 2019

IET nanobiotechnol.

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“…This disease is defined by the expression of estrogen, progesterone, and HER-2 [ 161 ]. Breast cancer cell receptors play a strong part in the treatment of this disease, as it forms the basis of a targeted strategy for treatment.…”

Section: Application and Clinical Trials Of Nanocarrier-based Thermentioning

confidence: 99%

Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

Wei

Lau

2020

Cancers

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Conventional chemotherapy is still an important option of cancer treatment, but it has poor cell selectivity, severe side effects, and drug resistance. Utilizing nanoparticles (NPs) to improve the therapeutic effect of chemotherapeutic drugs has been highlighted in recent years. Nanotechnology dramatically changed the face of oncology by high loading capacity, less toxicity, targeted delivery of drugs, increased uptake to target sites, and optimized pharmacokinetic patterns of traditional drugs. At present, research is being envisaged in the field of novel nano-pharmaceutical design, such as liposome, polymer NPs, bio-NPs, and inorganic NPs, so as to make chemotherapy effective and long-lasting. Till now, a number of studies have been conducted using a wide range of nanocarriers for the treatment of solid tumors including lung, breast, pancreas, brain, and liver. To provide a reference for the further application of chemodrug-loaded nanoformulations, this review gives an overview of the recent development of nanocarriers, and the updated status of their use in the treatment of several solid tumors.

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“…The morphology of THP-CAP-LPs was analysed using scanning electron microscopy (SEM) and transmission electron microscope (TEM). 13,14 Determination of drug entrapment efficiency and drug loading…”

Section: Application Of Central Composite Design (Ccd) For Optimizatimentioning

confidence: 99%

Tumor homing peptide modified liposomes of capecitabine for improved apoptotic activity and HER2 targeted therapy in breast cancer: in vitro studies

et al. 2019

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Nanocarrier based approaches for targeting breast cancer stem cells

Cited by 27 publications

References 145 publications

Facile synthesis of multi‐walled carbon nanotube via folic acid grafted nanoparticle for precise delivery of doxorubicin

Facile synthesis of multi‐walled carbon nanotube via folic acid grafted nanoparticle for precise delivery of doxorubicin

Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

Tumor homing peptide modified liposomes of capecitabine for improved apoptotic activity and HER2 targeted therapy in breast cancer: in vitro studies

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