Nanobuffering of pH-Responsive Polymers: A Known but Sometimes Overlooked Phenomenon and Its Biological Applications

Tao, Wei; Wang, Junqing; Parak, Wolfgang J.; Farokhzad, Omid C.; Shi, Jinjun

doi:10.1021/acsnano.9b01696

Cited by 82 publications

(61 citation statements)

References 62 publications

(107 reference statements)

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“…[ 18 ] Furthermore, pH‐responsive polymers were found to be able to protect a local range of pH on nanoscale where they were composed. pH condition within the compartment can be different from the environmental pH to show appealing nano‐buffering effect, [ 23 ] which has been applied for proof‐of‐concept purification of antibody [ 24 ] or enzyme cascade reaction. [ 25 ]…”

Section: Introductionmentioning

confidence: 99%

Confined Microenvironments from Thermoresponsive Dendronized Polymers

Liu

et al. 2020

Macromol. Rapid Commun.

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Confined microenvironments in biomacromolecules arising from molecular crowding account for their well‐defined biofunctions and bioactivities. To mimick this, synthetic polymers to form confined structures or microenvironments are of key scientific value, which have received significant attention recently. To create synthetic confined microenvironments, molecular crowding effects and topological cooperative effects have been applied successfully, and the key is balance between self‐association of structural units and self‐repulsion from crowding‐induced steric hindrance. In this article, formation of confined microenvironments from stimuli‐responsive dendronized polymers carrying densely dendritic oligoethylene glycols (OEGs) moieties in their pendants is presented. These wormlike thick macromolecules exhibit characteristic thermoresponsive properties, which can provide constrained microenvironments to encapsulate effectively guest molecules including dyes, proteins, or nucleic acids to prevent their protonation or biodegradation. This efficient shielding effect can also mediate chemical reactions in aqueous phase, and even enhance chirality transferring efficiency. All of these can be switched off simply through the thermally‐induced dehydration and collapse of OEG dendrons due to the amphiphilicity of OEG chains. Furthermore, the switchable encapsulation and release of guests can be greatly enhanced when these dendronized polymers are used as major constituents for fabricating bulk hydrogels or nanogels, which provide a higher‐level confinement.

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Section: Introductionmentioning

confidence: 99%

Confined Microenvironments from Thermoresponsive Dendronized Polymers

Liu

et al. 2020

Macromol. Rapid Commun.

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“…2D materials have a huge specific surface area, resulting in an effective load of fluorescent dyes, targeting molecules and therapeutic drugs [ [192] , [193] , [194] , [195] ]. In addition, many 2D materials exhibit great phototherapy performance, which makes combined therapy possible [ [196] , [197] , [198] , [199] ]. Gao, Nansha et al [ 200 ] prepared a nanocapsule by coating the BP nanosheets with PDA.…”

Section: Advantages and Disadvantages Of Two-dimensional Materials Inmentioning

confidence: 99%

Recent advances of two-dimensional materials in smart drug delivery nano-systems

Zhang

Fan

Chen

et al. 2020

Bioactive Materials

139

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Smart drug delivery nano-systems show significant changes in their physical or chemical properties in response to slight change in environmental physical and/or chemical signals, and further releasing drugs adjusted to the progression of the disease at the right target and rate intelligently. Two-dimensional materials possess dramatic status extend all over various scientific and technological disciplines by reason of their exceptional unique properties in application of smart drug delivery nano-systems. In this review, we summarized current progress to highlight various kinds of two-dimensional materials drug carriers which are widely explored in smart drug delivery systems as well as classification of stimuli responsive two-dimensional materials and the advantages and disadvantages of their applications. Consequently, we anticipate that this review might inspire the development of new two-dimensional materials with smart drug delivery systems, and deepen researchers’ understanding of smart nano-carries based on two-dimensional materials.

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“…In addition, subcellular compartments show different acidic microenvironments, with pH 5.0-6.5 in early and late endosomes, pH 4.5-5.0 in lysosomes, and pH 6.0-6.7 in the Golgi apparatus [ 63 , 105 ]. Regardless of pathological or physiological acidosis, the acidic environment has been widely studied as a trigger for site-specific drug delivery [ 65 , [105] , [106] , [107] ]. In particular, a large number of pH-responsive biomaterials and delivery systems have been engineered and applied for the treatment of inflammatory diseases.…”

Section: Inflammation and The Inflammatory Microenvironmentmentioning

confidence: 99%

Bioresponsive drug delivery systems for the treatment of inflammatory diseases

Ding

et al. 2020

Journal of Controlled Release

123

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Inflammation is intimately related to the pathogenesis of numerous acute and chronic diseases like cardiovascular disease, inflammatory bowel disease, rheumatoid arthritis, and neurodegenerative diseases. Therefore anti-inflammatory therapy is a very promising strategy for the prevention and treatment of these inflammatory diseases. To overcome the shortcomings of existing anti-inflammatory agents and their traditional formulations, such as nonspecific tissue distribution and uncontrolled drug release, bioresponsive drug delivery systems have received much attention in recent years. In this review, we first provide a brief introduction of the pathogenesis of inflammation, with an emphasis on representative inflammatory cells and mediators in inflammatory microenvironments that serve as pathological fundamentals for rational design of bioresponsive carriers. Then we discuss different materials and delivery systems responsive to inflammation-associated biochemical signals, such as pH, reactive oxygen species, and specific enzymes. Also, applications of various bioresponsive drug delivery systems in the treatment of typical acute and chronic inflammatory diseases are described. Finally, crucial challenges in the future development and clinical translation of bioresponsive anti-inflammatory drug delivery systems are highlighted.

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Nanobuffering of pH-Responsive Polymers: A Known but Sometimes Overlooked Phenomenon and Its Biological Applications

Cited by 82 publications

References 62 publications

Confined Microenvironments from Thermoresponsive Dendronized Polymers

Confined Microenvironments from Thermoresponsive Dendronized Polymers

Recent advances of two-dimensional materials in smart drug delivery nano-systems

Bioresponsive drug delivery systems for the treatment of inflammatory diseases

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