Nanobiotechnology: the promise and reality of new approaches to molecular recognition

Fortina, Paolo; Kricka, Larry J.; Surrey, Saul; Grodzinski, Piotr

doi:10.1016/j.tibtech.2005.02.007

Cited by 215 publications

(115 citation statements)

References 43 publications

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“…These materials show promise for a wide array of applications, including substrates for neuronal cell growth (Mattson et al 2000;Hu et al 2004;Lovat et al 2005), scaffolding for tissue and bone growth (Usui et al 2008), supports for liposaccharides to mimic cell membranes (Chen et al 2004), ion channel blockers (Park et al 2003a(Park et al , 2003b, tumor imaging (Zavaleta et al 2008), and drug delivery systems (Bianco and Prato 2003;Bianco et al 2005aBianco et al , 2005bBianco et al , 2005cBagonluri 2008a, 2008b). In addition to their medical applications, carbon nanotubes are expected to advance electronics, within energy storage devices, thermal insulators, conducive fillers, and molecular electronic devices (Baughman 2000;Gao et al 2000;Katz and Willner 2004;Bianco et al 2005bBianco et al , 2005cFortina et al 2005). Because carbon nanotubes are projected to be incorporated into manufactured goods valued in the trillions over the next 5-10 years, there is a potential for human exposure in industrial settings and a strong need to understand the potential health effects of these materials.…”

Section: Introductionmentioning

confidence: 99%

Aerosolization System for Experimental Inhalation Studies of Carbon-Based Nanomaterials

Madl

Teague²,

et al. 2012

Aerosol Science and Technology

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Assessing the human health risks associated with engineered nanomaterials is challenging because of the wide range of plausible exposure scenarios. While exposure to nanomaterials may occur through a number of pathways, inhalation is likely one of the most significant potential routes of exposure in industrial settings. An aerosolization system was developed to administer carbon nanomaterials from a dry bulk medium into airborne particles for delivery into a nose-only inhalation system. Utilization of a cannula-based feed system, diamond-coated wheel, aerosolization chamber, and krypton-85 source allows for delivery of otherwise difficult to produce respirable-sized particles. The particle size distribution (aerodynamic and actual) and morphology were characterized for different aerosolized carbon-based nanomaterials (e.g., single-walled carbon nanotubes and ultrafine carbon black). Airborne particles represented a range of size and morphological characteristics, all of which were agglomerated particles spanning in actual size from the nanosize range (<0.1 µm) to sizes greater than 5 and 10 µm for the particle's largest dimension. At a mass concentration of 1000 µg/m 3 , the size distribution as measured by the inertial impactor ranged from 1.3 to 1.7 µm with a σ g between 1.2 and 1.4 for all nanomaterial types. Because the aerodynamic size distribution is similar across different particle types, this system offers an opportunity to explore mechanisms by which different nanomaterial physicochemical characteristics impart different health effects while theoretically maintaining comparable deposition patterns in the lungs. This sys-

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Section: Introductionmentioning

confidence: 99%

Aerosolization System for Experimental Inhalation Studies of Carbon-Based Nanomaterials

Madl

Teague²,

et al. 2012

Aerosol Science and Technology

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“…Nanoscale cantilevers can scan sample and yield hybridization with the single-stranded DNA when the targeted sequence is determined. This is another important feature of cantilevers that can permit multiple analyses (Fortina et al, 2005;Jain, 2003).…”

Section: Nanoscale Cantileversmentioning

confidence: 99%

“…They can also be adapted for analytes other than DNA, e.g., by attaching enzyme to detect substrate analyte (Azzazy et al, 2006;Fortina et al, 2005). Nanotubes offer interesting advantages that are relative to or better than spherical nanoparticles in some biotechnological and diagnostic applications (Kong et al, 2006).…”

Section: Nanotubesmentioning

confidence: 99%

Roles of Nanotechnological Approaches in Periodontal Disease Therapy

Aminu¹,

Chan²,

Toh³

2017

J App Pharm Sci

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Formulation scientists are faced with a great hurdle of delivering a therapeutic agent into the periodontal pockets because of the anatomical complexity of the route and the lesion's contours that often leads to poor penetration of the drug to the area. However, recent nanotechnology advancement and innovations through nanodentistry are increasingly providing a suitable solution for the treatment of many dental disorders including periodontal disease. These nanodentistry innovative approaches have vowed to revolutionize dental therapeutics by way of using nanomaterials, biotechnology, and nanorobotics, that can significantly influence and transform dental disease's diagnosis, prevention, and treatment. The advances have offered possibilities for providing highquality dental care to a vast number of people around the globe who are currently suffering from periodontal disease. Novel nanotechnology-based carriers and materials such as polymeric nanoparticles, nanogels, nanopores, nanotubes, scaffold matrices, nanoneedles, nanocrystals, quantum dots, nanofibers, and nanofillers have demonstrated promising efficacy and their roles in the disease therapy are of great significance. The aim of this review article is to provide important recent updates on the various nanotechnology-base approaches for periodontal disease therapy. The roles of these recently investigated approaches in the disease treatment are also covered in the review.

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“…Semiconductor nanocrystals, also known as quantum dots (QDs), have attracted great fundamental and industrial interest in recent years [1][2][3] . Because of the quantum confinement effect 4,5 , the continuous energy band structure was changed into a discrete energy level structure with molecular characterization.…”

Section: Introductionmentioning

confidence: 99%

Study on the Fluorescence Characteristics of CdTe and Charged Coumarin-Contained Polymer Blending System

Wang¹,

Li²,

Chen³

et al. 2013

Asian J. Chem.

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In this paper, a series of positively charged coumarin-contained polymer (C-CPA) were synthesized and a negatively charged CdTe quantum dots (CdTe QDs) protected by thioglycolic acid (TGA) was prepared. C-CPA and CdTe QDs were blended in mixed solution to build a blending system. The photoluminescent properties of both C-CPA and CdTe QDs were studied and the influence of the solvent on the size of CdTe QDs was studied as well. By controlling the proportions of the two mixtures, some regularly phenomena were found. As the proportion of CdTe QDs rising in the mixture, the fluorescence intensity of C-CPA declined; as the proportion of C-CPA rising, the fluorescence intensity of CdTe QDs rose significantly. These phenomena followed the fluorescence resonance energy transfer theory (FRET). The electrostatic force between the two mixtures caused the interaction between them. The study confirmed that an energy donor-acceptor pair was formed in this blending system.

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Nanobiotechnology: the promise and reality of new approaches to molecular recognition

Cited by 215 publications

References 43 publications

Aerosolization System for Experimental Inhalation Studies of Carbon-Based Nanomaterials

Aerosolization System for Experimental Inhalation Studies of Carbon-Based Nanomaterials

Roles of Nanotechnological Approaches in Periodontal Disease Therapy

Study on the Fluorescence Characteristics of CdTe and Charged Coumarin-Contained Polymer Blending System

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