Nanobiotechnology in Neurodegenerative Diseases

Jampílek, Josef; Kráľová, Katarína; Novák, Petr; Novák, Michal

doi:10.1007/978-3-030-30930-5_4

Cited by 11 publications

(17 citation statements)

References 436 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of suitable DDSs allows overcoming those problems and ensuring the transfer of a drug to the infected site with consequent release under selected conditions [ 60 , 63 , 64 , 65 , 66 ]. The use of nano-scale drug carriers appears to increase drug specificity and leads to a reduction in adverse effects due to the reduced drug dose [ 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 ] (see Figure 2 ).…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

“…NanoDDS are widely investigated for cancer therapy, cardiovascular diseases treatment, anemia, and hemophilia treatment, in nutraceutical delivery, and also for neurodegenerative, infectious, autoimmune, ocular, and pulmonary diseases as well as for diagnostic, regenerative therapy, and other purposes [ 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 84 , 85 ].…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

See 1 more Smart Citation

Chronic Inflammatory Diseases, Anti-Inflammatory Agents and Their Delivery Nanosystems

Plachá

Jampílek

2021

Pharmaceutics

View full text Add to dashboard Cite

Inflammatory diseases, whether caused by excessive stress on certain tissues/parts of the body or arising from infections accompanying autoimmune or secondary diseases, have become a problem, especially in the Western world today. Whether these are inflammations of visceral organs, joints, bones, or the like, they are always a physiological reaction of the body, which always tries to eradicate noxious agents and restore tissue homeostasis. Unfortunately, this often results in damage, often irreversible, to the affected tissues. Nevertheless, these inflammatory reactions of the body are the results of excessive stress, strain, and the generally unhealthy environment, in which the people of Western civilization live. The pathophysiology and pathobiochemistry of inflammatory/autoimmune processes are being studied in deep detail, and pharmaceutical companies are constantly developing new drugs that modulate/suppress inflammatory responses and endogenous pro-inflammatory agents. In addition to new specifically targeted drugs for a variety of pro-inflammatory agents, a strategy can be found for the use of older drugs, which are formulated into special nanodrug delivery systems with targeted distribution and often modified release. This contribution summarizes the current state of research and development of nanoformulated anti-inflammatory agents from both conventional drug classes and experimental drugs or dietary supplements used to alleviate inflammatory reactions.

show abstract

Section: Drug Delivery Systemsmentioning

confidence: 99%

Section: Drug Delivery Systemsmentioning

confidence: 99%

Chronic Inflammatory Diseases, Anti-Inflammatory Agents and Their Delivery Nanosystems

Plachá

Jampílek

2021

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Currently, nanoforms made from non-toxic biodegradable materials are preferred; however, in the case of nanoformulations for cancer therapy or diagnosis, inorganic carriers such as NPs of metals, metal oxides, metalloids and carbon are also used, which often potentiate the effect of the API itself [19][20][21][22][23][24][25][26][27][28][29][30]. It is important to mention that drugs in the nanoform acquire unique physicochemical properties and in particular their bioavailability after oral administration is modified, thanks to improved permeability through membranes [6,[31][32][33][34][35][36][37][38][39][40]. In addition, drug delivery nanosystems (nanoDDSs) make it easy to achieve a targeted distribution, whether it is a passive distribution based on the particle size of the NPs or the so-called EPR (Enhanced Permeability and Retention factor) effect, active distribution, i.e., by modifying the NP surface with an antibody, ligand, etc., or in the case of magnetic NPs by an external magnetic field.…”

Section: Introductionmentioning

confidence: 99%

“…Very often, albumin, aptamer A10, hyaluronic acid (HA, Figure 1), folic acid (FA, Figure 1) or biotin ( Figure 1) are used. Total hydrophilicity and "invisibility" against phagocytes are ensured by surface modification using polyethylene glycol (PEG, Figure 1) by so-called PEGylation [12,37,[41][42][43][44][45][46][47][48][49][50]. Carbon is one of the most abundant elements on Earth.…”

Section: Introductionmentioning

confidence: 99%

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

Jampílek

Kráľová

2021

Materials

View full text Add to dashboard Cite

Carbon is one of the most abundant elements on Earth. In addition to the well-known crystallographic modifications such as graphite and diamond, other allotropic carbon modifications such as graphene-based nanomaterials and carbon nanotubes have recently come to the fore. These carbon nanomaterials can be designed to help deliver or target drugs more efficiently and to innovate therapeutic approaches, especially for cancer treatment, but also for the development of new diagnostic agents for malignancies and are expected to help combine molecular imaging for diagnosis with therapies. This paper summarizes the latest designed drug delivery nanosystems based on graphene, graphene quantum dots, graphene oxide, reduced graphene oxide and carbon nanotubes, mainly for anticancer therapy.

show abstract

“…Moreover, multiple studies in rodents and humans have shown that Cur crosses the blood–brain barrier (BBB) [ 5 ]. However, despite its many biological activities, Cur is not often used in clinical applications because of two main intrinsic properties: Low bioavailability due to its limited solubility in water (11 ng/mL) and low permeability (LogP 3.28) [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of New Water Soluble β-Cyclodextrin@Curcumin Conjugates and In Vitro Safety Evaluation in Primary Cultures of Rat Cortical Neurons

Ben-Mihoub

Acherar

Frochot

et al. 2021

IJMS

View full text Add to dashboard Cite

Self-aggregation of Curcumin (Cur) in aqueous biological environment decreases its bioavailability and in vivo therapeutic efficacy, which hampers its clinical use as candidate for reducing risk of neurodegenerative diseases. Here, we focused on the design of new Cur- β-Cyclodextrin nanoconjugates to improve the solubility and reduce cell toxicity of Cur. In this study, we described the synthesis, structural characterization, photophysical properties and neuron cell toxicity of two new water soluble β-CD/Cur nanoconjugates as new strategy for reducing risks of neurodegenerative diseases. Cur was coupled to one or two β-CD molecules via triazole rings using CuAAC click chemistry strategy to yield β-CD@Cur and (β-CD)2@Cur nanoconjugates, respectively. The synthesized nanoconjugates were found to be able to self-assemble in aqueous condition and form nano-aggregates of an average diameter size of around 35 and 120 nm for β-CD@Cur and (β-CD)2@Cur, respectively. The photophysical properties, water solubility and cell toxicity on rat embryonic cortical neurons of the designed nanoconjugates were investigated and compared to that of Cur alone. The findings revealed that both new nanoconjugates displayed better water solubility and in vitro biocompatibility than Cur alone, thus making it possible to envisage their use as future nano-systems for the prevention or risk reduction of neurodegenerative diseases.

show abstract

Nanobiotechnology in Neurodegenerative Diseases

Cited by 11 publications

References 436 publications

Chronic Inflammatory Diseases, Anti-Inflammatory Agents and Their Delivery Nanosystems

Chronic Inflammatory Diseases, Anti-Inflammatory Agents and Their Delivery Nanosystems

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

Synthesis of New Water Soluble β-Cyclodextrin@Curcumin Conjugates and In Vitro Safety Evaluation in Primary Cultures of Rat Cortical Neurons

Contact Info

Product

Resources

About