Nanobiostructure of fibrous-like alumina functionalized with an analog of the BP100 peptide: Synthesis, characterization and biological applications

Antimicrobial alumina nanobiostructures of disulfide- and triazole-linked peptides: Synthesis, characterization, membrane interactions and biological activity

“…These signals confirm the cycloaddition reaction between the alkyne-decorated peptides ([Pra]GAAA-BP100 and [Pra]G 34 -DD K) and the azide-nanoparticles (NP-N 3 ). nanoparticles ( Figure S4) clearly shows the presence of organic structures on the surface of the functionalized samples [15]. A well-defined mass loss (2-5%) was observed around 380°C for the samples NP-NH 2 , NP-Cys and NP-CAAA.…”

“…The presence of the aminopropyl group in NP-NH 2 and of the α-amino termini in the NP-Cys raise the ζ-potential values to +30.5 and +23.0, respectively. Although with less magnitude, due the low substitution degree of peptide, an increase in the ζ-potential value in comparison with NPeOH was reached for NP-CAAA-BP100 (+17.2) also, as the result of the presence of five Lys residues in the peptide chain [15].…”

“…XRD, TEM and HRTEM -According to the qualitative analysis of the XRD patterns [15]. the synthesized nanoparticles obtained before functionalization with peptides (NP, NP-OH, NP-NH 2 , NP-Cys, NP-Cl, and NP-N 3 ) consist of a single phase corresponding to a cubic structure of γ-Al 2 O 3 (Fd-3 m, Figure S2) [21].…”

“…It was only recently shown that a peptide-alumina nanoparticle conjugate can be highly effective for the treatment of some biological conditions, such as allergic asthma in rats [14]. Very recently, our team proved the antimicrobial potential of nanofibrous alumina covalently bound to the antimicrobial peptide BP100 in assays against Escherichia coli and Salmonella typhimurium strains [15]. These results indicated that peptide-decorated nanobiostructures may present important applications in food packaging in order to avoid microbial contamination and improve food shelf-life [16,17].…”

Efficiency of gold nanoparticles coated with the antimicrobial peptide indolicidin against biofilm formation and development of <em>Candida </em>spp. clinical isolates

“…It has been reported that functionalization of NPs with AMPs overcomes problems such as proteolytic degradation and peptide self-aggregation, maintaining their antimicrobial properties. 46 …”