Antimicrobial alumina nanobiostructures of disulfide- and triazole-linked peptides: Synthesis, characterization, membrane interactions and biological activity

Nanostructured Antimicrobial Peptides: Crucial Steps of Overcoming the Bottleneck for Clinics

“…Metal nanoparticles (MNPs) have emerged as promising antimicrobial vectors against ESKAPE pathogens in the last decades due to their potent therapeutic potential, readily adjustable shape and size, manageable drug delivery and release, and less probability of microbial resistance ( Gupta et al, 2021 ). The studies about MNPs with conjugated AMPs are versatile and can be categorized into gold nanoparticles ( Zheng et al, 2019 ), silver nanoparticles ( Gao et al, 2020 ), alumina nanoparticles ( Torres et al, 2019 ), ruthenium nanoparticles ( Huang et al, 2017 ), copper nanoparticles ( Ishida et al, 2020 ), hybrid nanoparticles, etc., depending on the types and state of metal nanoparticles ( Yang et al, 2020 ). Among all MNPs, silver (Ag) and gold (Au) nanoparticles with conjugated AMPs have been widely studied and used due to their appealing antimicrobial activity.…”

“…Depending on the easily modified and flexible physicochemical properties, NPs have reflected targeted therapy and excellent antimicrobial properties ( Zhang W. et al, 2014 ; Otari et al, 2017 , 2019 ; Patel et al, 2019a ). Due to the high surface-to-volume ratios of NPs, the contact surface between NPs and bacteria membranes was increased, which resulted in the destruction of the cell permeability and physiological functions of membranes, then the disruption of cellular functions caused by interacting with intracellular proteins and DNA, generating reactive oxygen species (ROS) ( Li et al, 2017 ; Torres et al, 2019 ; Zheng et al, 2019 ). Hence, the peculiar antimicrobial mechanisms of NPs are employed to kill pathogens quickly and further reduce, or are less prone to, bacteria resistance by multiple antibacterial models.…”

The Effects of Luminescent CdSe Quantum Dot-Functionalized Antimicrobial Peptides Nanoparticles on Antibacterial Activity and Molecular Mechanism

“…However, their poor biocompatibility is one of the main obstacles to the clinical development of a large number of common AP. 14 , 15 Target delivery of AP is necessary due to their short half-life and relative toxicity against healthy cells. 16 The effective use of nanoscale proteins and peptides in therapeutic and diagnostic methods is a strategy to induce and maintain their functional conformation.…”

“…Research on nano-modification based on AP has shown that they can be combined with nanoparticles (NPs) to form nanomaterials with novel properties, due to their advantages in molecular recognition and antibacterial activity. 15 , 17 , 18 Currently, quantum dots (QDs) not only have very important applications in solar cells and phototransistor components, but also in biological applications including biosensors, 19 , 20 bioimaging 21 and biomedical research. 22 Cadmium selenide (CdSe) QDs with a size of 1–20 nm are currently used for in vivo imaging and diagnostic treatment.…”

Synthesis, antibacterial, and antioxidant activities of naphthyl‐linked disubstituted 1,2,3‐triazoles

“…In recent years, chemical and biological usefulness of heterocyclic compounds attracted attention of chemist in form of pharmaceuticals, agrochemicals, polymers, dyes, etc . Triazole, a five‐membered heterocycle is key important, as its derivatives exhibited various biological activities such as antibacterial, antimalarial, antitubercular, anticancer, antiparasitic, antileishmanial, antioxidant, anti‐inflammatory, antidepressant, antiviral, etc. The 1,2,3‐triazole derivatives play an intriguing role in the development of new drugs, as effectively exerts various non‐covalent interactions which improves the solubility and the ability of binding to bimolecular targets …”