Nanoassembling of thixotropically reversible alumino-siloxane hybrid gels to hierarchically porous aerogel framework

Linsha, Vazhayal; Mohamed, Alaa; Ananthakumar, S.

doi:10.1016/j.cej.2014.07.137

Cited by 21 publications

(17 citation statements)

References 34 publications

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“…Recently, investigations have focused on using aerogels as new supports to form amine-based CO 2 adsorbents, due to their unique physical properties such as low density, high surface area and porosity [22][23][24][25][26]. Also, the microstructures and elemental compositions of aerogels can be tailored using solution chemistry via a process known as the sol-gel method [27,28].…”

Section: Introductionmentioning

confidence: 99%

Dynamic capture of low-concentration CO2 on amine hybrid silsesquioxane aerogel

Kong

Shen

Fan

et al. 2016

Chemical Engineering Journal

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Section: Introductionmentioning

confidence: 99%

Dynamic capture of low-concentration CO2 on amine hybrid silsesquioxane aerogel

Kong

Shen

Fan

et al. 2016

Chemical Engineering Journal

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“…Fabrication of Alumino-Siloxane Aerogel Microbeads. ALS gel was prepared by the sol−gel co-condensation method as described in our previous report with some modifications 27 (details are given in S1). The pollen-templated hierarchically porous ALS-PG microbeads were prepared by an "oil drop granulation method".…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…Self-assembly of the gel in the oil layer forms well-defined microbeads due to the surface tension. These wet gel microbeads were then converted to aerogel microbeads as per the procedure described in our previous work 27 (details are given in S3). For comparative studies, we have also prepared corresponding xerogel samples.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…We have recently reported the synthesis of thixotropically reversible ALS gels to form aerogels and xerogels microbeads. 27 Here, we attempted to build on our previous work, by engineering multilevel porosity through inherited pore morphological features of natural pollen grains, which are implausible to produce artificially. Most importantly, the hierarchically porous ceramic ALS aerogel supports were explored for steapsin lipase immobilization for biocatalytic application.…”

Section: ■ Introductionmentioning

confidence: 99%

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Biocatalytic Conversion Efficiency of Steapsin Lipase Immobilized on Hierarchically Porous Biomorphic Aerogel Supports

Linsha

Shuhailath

Mahesh

et al. 2016

ACS Sustainable Chem. Eng.

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Hierarchically porous alumino-siloxane aerogels (ALS-PG) with a rare structural architecture were developed through a biotemplating method using pollen grains of Hibiscus rosa-sinensis. The unique structure of the Hibiscus rosa-sinensis pollen makes it an attractive biotemplate, by replicating all levels of macro-and mesoscale morphological features. The micromorphological analysis exposed funnelshaped macrochannels between the mesoporous aerogel framework that are difficult to design artificially. The N 2 sorption analyses confirmed hierarchical trimodal pore size distribution with an average mesopores diameter (ca. 3.9, 8.7, 26.6 nm), high BET/Langmuir surface area (497/664 m 2 g −1 ) and large pore volume (1.6788 cm 3 g −1 ) than the corresponding nontemplated aerogels and xerogels counterpart. Beneficial properties of this sophisticated hierarchical porous structure was examined and confirmed by the immobilization of steapsin lipase. Hierarchically porous ALS-PG showed enhanced loading and immobilization efficiency (32.3 mg g −1 and 74.21%) when compared to non templated ALS-WO-PG (11.2 mg g −1 and 41.40%). It was further improved with the methyl

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“…Previously our group reported the fabrication of alumino-siloxane aerogel microspheres using these gels. 22 The notable contribution reported in that work is the occurrence of a unique 2D nanotape-like architecture in the ALS building blocks in a very narrow gelling condition and also their self-organization into a stable 3D gel cage without any polymers or chemical additives/organic solvents. Additionally, a mechano-responsive smart function is rare in an aqueous gel system.…”

Section: Introductionmentioning

confidence: 97%

Supramolecular association of 2D alumino-siloxane aquagel building blocks to 3D porous cages and its efficacy for topical and injectable delivery of fluconazole, an antifungal drug

et al. 2015

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The supramolecular assembly of stimuli-responsive gels is renowned in organic, polymeric and biological systems, but it is seldom reported in inorganic gel systems. Here we report the inorganic system aluminosiloxane (ALS) aquagel by sol-gel synthesis that shows a unique mechano-responsive property with an impressive recovery rate. An assembly of 2D nanoribbon/tape like structural architectures was distinctively identified as the primary building block of the aquagel structure. This fascinating 2D architecture selfassembled into a well-defined 3D porous aquagel cage via weak supramolecular interactions. This is identified to be an excellently mechanically stable, injectable and non-cytotoxic medium for drug delivery applications. The ALS aquagel can also overcome the untoward effects caused by photoinitiators, chemical cross-linking agents and organic solvents in organo/polymeric gels when it is used for biomedical applications. Herein, we successfully utilized the ALS inorganic aquagel for the encapsulation and sustained release of fluconazole (FLZ), an antifungal drug, for the first time. The FLZ loaded aquagel showed good antifungal susceptibility against various fungi species, such as Candida albicans, Candida tropicalis and Trichophyton rubrum. The FLZ-ALS aquagel showed an eight-fold enhancement in antifungal susceptibility against the most threatening Candida fungi species when compared to the marketed formulation.

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Nanoassembling of thixotropically reversible alumino-siloxane hybrid gels to hierarchically porous aerogel framework

Cited by 21 publications

References 34 publications

Dynamic capture of low-concentration CO2 on amine hybrid silsesquioxane aerogel

Dynamic capture of low-concentration CO2 on amine hybrid silsesquioxane aerogel

Biocatalytic Conversion Efficiency of Steapsin Lipase Immobilized on Hierarchically Porous Biomorphic Aerogel Supports

Supramolecular association of 2D alumino-siloxane aquagel building blocks to 3D porous cages and its efficacy for topical and injectable delivery of fluconazole, an antifungal drug

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