Nano-porous nitrocellulose liquid bandage modulates cell and cytokine response and accelerates cutaneous wound healing in a mouse model

Mu, Xiaofeng; Yu, Hao; Zhang, Caizhen; Chen, Xiufang; Cheng, Zhiyun; Bai, Ruyu; Wu, Xunxun; Yu, Qian; Wu, Chunlin; Diao, Yong

doi:10.1016/j.carbpol.2015.08.070

Cited by 33 publications

(34 citation statements)

References 29 publications

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“…3 and 4, the re-epithelialization rate and thickness of epidermis is significantly enhanced in the LoBSLB-treated group compared with Vehicle-treated group. Similar results were obtained for surgical wounds in ICR mice-treated with nano-porous nitrocellulose LB, where application of the nitrocellulose LB onto surgical skin wounds exhibited enhanced wound re-epithelialization, contraction and granular tissue formation when compared with control-treated group (10). However, the results obtained in the HiBSLB-treated group was dissimilar; we observed a constant level of epidermal thickening and only slight increase of re-epithelialization rate at day 12.…”

Section: Discussionsupporting

confidence: 75%

“…These results were consistent with a previous study using topical application of nano-porous nitrocellulose LB. The cellulose significantly increased the wound closure as compared to the control group in ICR mice, although their change rate varied in each group (10). These two studies therefore show that LB prepared with cellulose powder promotes the rate of cutaneous wound healing.…”

Section: Discussionmentioning

confidence: 99%

“…LB is a chemical mixture which forms a thin polymeric layer on the skin; this characteristic has found a use as a topical skin treatment for minor cuts and sores (13). In humans, it stimulates the skin wound repair by retaining an adequate moisture balance and protecting the wound from infections (10,14). Extensive preparations of liquid bandage (LB) using various other polymers have been used, including polyvinylpyrrolidone, ethyl cellulose, pyroxylin/nitrocellulose, poly (methylacrylate-isobutene-monoisopropylmaleate), and acrylate or siloxane polymers (13).…”

Section: Introductionmentioning

confidence: 99%

“…2-octyl-cyanoacrylate is the most common polymer for preparing LB applied to cornea, sclera, eyelid skin grafts, and mucous membrane grafts during socket reconstruction, and for temporary treatment of myopathic blepharoptosis after botulinum toxin injection (15–19). Studies involving cellulose as a polymer material for LB preparation are limited; only one previous study attempted application of nano-porous nitrocellulose LB for wound healing, and presented the physicochemical properties and therapeutic effects on cutaneous wound healing in an ICR model (10).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Therapeutic effects of a liquid bandage prepared with cellulose powders from Styela�clava tunics and Broussonetia�kazinoki bark: Healing of surgical wounds on the skin of Sprague Dawley rats

et al. 2018

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Cellulose in different forms has extensively been applied in biomedical treatments, including scaffolding, tissue engineering and tissue formation. To evaluate the therapeutic effects of a liquid bandage (LB) prepared with cellulose powders from Styela clava tunics (SCT) and Broussonetia kazinoki bark (BSLB) for healing cutaneous wounds, the remedial effects of a low concentration (LoBSLB) and a high concentration (HiBSLB) of BSLB on skin regeneration and toxicity in Sprague Dawley rats. Results indicated that the total area of skin involved in the surgical wound was lower in the BSLB-treated group compared with the Vehicle-treated group at days 4–12, although some variations were observed in the HiBSLB-treated group. In addition, the BSLB-treated group showed significantly enhanced width of the re-epithelialization region and epidermal thickness when compared with the Vehicle-treated group. Furthermore, significant stimulation in the expression level of collagen-1 and the signaling pathway of VEGF after topical application of BSLB was indicated. No liver or kidney toxicities were detected for either doses of BSLB. Overall, the results of the present study suggest that BSLB accelerates the process of wound healing in surgical skin wounds of Sprague Dawley rats through stimulation of re-epithelialization and connective tissue formation, without any accompanying significant toxicity.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Therapeutic effects of a liquid bandage prepared with cellulose powders from Styela�clava tunics and Broussonetia�kazinoki bark: Healing of surgical wounds on the skin of Sprague Dawley rats

et al. 2018

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“…The ZnO NR-MWCNT composite film can be applied in the fabrication of antimicrobial bandage material used for covering wounds and minor skin injuries, providing breathable, antimicrobial and flexible bandage material that can support the growth of tissues while providing antimicrobial action and preventing skin infections. The porous structure of ZnO NR-MWCNT composite films may also help in faster wound healing [44]. 3.7b Antifungal property: Antifungal property of the film samples was studied by AATCC 30, III method using T. mentagrophytes fungus.…”

Section: Application Of Composite Film As An Antimicrobial Bandage Mamentioning

confidence: 99%

Preparation of ZnO nanoribbon–MWCNT composite film and its application as antimicrobial bandage, antibacterial filter and thermal IR camouflage material

et al. 2017

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A zinc oxide nanoribbon (ZnO NR)-multiwall carbon nanotube (MWCNT) composite film was prepared by filtration technique. The film was characterized by X-ray diffraction spectroscopy, scanning electron microscopy (SEM), Raman spectroscopy, infrared (IR) spectroscopy and reflectance spectroscopy. The SEM images showed ZnO NRs trapped in the porous MWCNT network. This composite film displayed a strong antimicrobial property and porous structure, which has potential application as an antimicrobial bandage material. The composite film successfully removed the Escherichia coli bacteria from water and destroyed the bacteria retained on its surface due to the antibacterial action of ZnO NRs. The absorption of thermal IR radiation by the composite film was studied by thermography, which can be useful in IR camouflage applications.

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Polyvinyl alcohol composite gel membrane modified by natural polysaccharide and waterborne polyurethane

Shao,

Li,

Tan

et al. 2023

Polymer Engineering & Sci

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A new composite gel material was obtained by blending polyvinyl alcohol (PVA) aqueous solution with sodium alginate (SA), sodium carboxymethyl cellulose (CMC‐Na), waterborne polyurethane (WPU), and polyvinylpyrrolidone (PVP). Titanium dioxide nanoparticles (nTiO2) were doped as an antibacterial agent. The liquid composite could to form a transparent protective gel membrane. The microstructure of the gel membrane was observed via scanning electron microscopy, and the intermolecular interaction was investigated by total reflection infrared spectroscopy. The results demonstrated a homogeneous phase and significant hydrogen bonding between chain segments. The best results indicated that the equilibrium swelling rate increased from 147% to 170%, the 3‐h water vapor transmission rate increased from 279.41 g/m2∙day to 374.75 g/m2∙day, and the water contact angle increased from 16.8° to 60.7°, relative to the PVA substrate. The properties of this composite gel material suggest possible biomedical usage, particularly in skin and wound protection scenarios.Highlights A novel gel film‐forming material consisting of a viscous liquid is prepared. Adding polysaccharides modifiers resulted in significant improvements of the performance. The bacteriostatic and antihemorrhagic properties are introduced to the material. Low‐irritating materials were used to prepare the gel material.

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Nano-porous nitrocellulose liquid bandage modulates cell and cytokine response and accelerates cutaneous wound healing in a mouse model

Cited by 33 publications

References 29 publications

Therapeutic effects of a liquid bandage prepared with cellulose powders from Styela�clava tunics and Broussonetia�kazinoki bark: Healing of surgical wounds on the skin of Sprague Dawley rats

Therapeutic effects of a liquid bandage prepared with cellulose powders from Styela�clava tunics and Broussonetia�kazinoki bark: Healing of surgical wounds on the skin of Sprague Dawley rats

Preparation of ZnO nanoribbon–MWCNT composite film and its application as antimicrobial bandage, antibacterial filter and thermal IR camouflage material

Polyvinyl alcohol composite gel membrane modified by natural polysaccharide and waterborne polyurethane

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