Nano-Phytosome: A Developing Platform for Herbal Anti-Cancer Agents in Cancer Therapy

Babazadeh, Afshin; Zeinali, Mahdi; Hamishehkar, Hamed

doi:10.2174/1389450118666170508095250

Cited by 85 publications

(52 citation statements)

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“…Owing to their improved cellular uptake of phyto‐active constituents, the dose requirement is reduced. However, the major disadvantage of these structures is attributed to the rapid elimination of phyto‐constituents from phytosomes (Babazadeh, Zeinali, & Hamishehkar, 2018; Pawar & Bhangale, 2015). Inorganic nanoparticles can be simply functionalized.…”

Section: Nanotechnology Approaches For Improving Rutin Effectsmentioning

confidence: 99%

Therapeutic benefits of rutin and its nanoformulations

Negahdari

Bohlouli

Sharifi

et al. 2020

Phytotherapy Research

153

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Background Rutin as a natural flavonoid compound has revealed an extensive range of therapeutic potentials. Purpose The current paper is focused on the numerous studies on rutin nanoformulations regarding its broad spectrum of therapeutic potentials. Study and methods A review was conducted in electronic databases (PubMed) to identify relevant published literature in English. No restrictions on publication date were imposed. Results The literature search provided 7,078 results for rutin. Among them, 25 papers were related to the potential biological activities of rutin nanoformulations. Polymeric nanoparticles were the most studied nanoformulations for rutin (14 titles) and lipid nanoparticles (5 titles) were in second place. The reviewed literature showed that rutin has been used as an antimicrobial, antifungal, and anti‐allergic agent. Improving the bioavailability of rutin using novel drug‐delivery methods will help the investigators to use its useful effects in the treatment of various chronic human diseases. Conclusion It can be concluded that the preparation of rutin nanomaterials for the various therapeutic objects confirmed the enhanced aqueous solubility as well as enhanced efficacy compared to conventional delivery of rutin. However, more investigations should be conducted to confirm the improved bioavailability of the rutin nanoformulations.

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Section: Nanotechnology Approaches For Improving Rutin Effectsmentioning

confidence: 99%

Therapeutic benefits of rutin and its nanoformulations

Negahdari

Bohlouli

Sharifi

et al. 2020

Phytotherapy Research

153

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“…One reason might be the changed drug uptake pathway. The free drugs were taken up by passive transport, while the phytosomes were taken up through endocytosis [39]. Besides, the phytosomes containing abundant phospholipids could carry amphiphilic agents to cross the cell membrane resulting in high intracellular drug concentrations, which might change the action mechanisms of P2.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells

Xu¹,

Xu²,

Li³

et al. 2019

Beilstein J. Nanotechnol.

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Diosgenin (Di), a steroidal sapogenin derived from plants, has been shown to exert anticancer effects in preclinical studies. Using Di as a starting material, various Di derivatives were designed and synthesized, aiming to discover new steroid-based antitumor agents. In this work, we synthesized several Di derivatives and screened FZU-0021-194-P2 (P2), which showed more potent cytotoxic activities against human non-small-cell lung cancer A549 and PC9 cells. Considering that Di has a unique sterol structure similarly to cholesterol, P2 phytosomes (P2Ps) were prepared to further improve the water solubility of P2. The P2Ps exhibited a particle size of 53.6 ± 0.3 nm with oval shape and a zeta potential of −4.0 ± 0.7 mV. P2Ps could inhibit the proliferation of lung cancer cells more efficiently than Di phytosomes after 72 h of incubation time by inducing cell cycle arrest and apoptosis. The results indicated that P2Ps could be a promising anticancer formulation for non-small-cell lung cancer.

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“…210,211 The biggest difference between liposomes and phytosomes is that, in liposomes, the active phytocompound is distributed in lipid layers of the membrane or in the medium containing a cavity, 211 whereas, in phytosomes, it is an integral part of the membrane, which gives the greater stability and better bioavailability because of the chemical links between active phytocompounds and phospholipid molecules ( Figure 2). 213,214 Yu et al 101 prepared phytosomes loaded with berberine phospholipid complex using the…”

Section: Phytosomesmentioning

confidence: 99%

<p>Oral Nano Drug Delivery Systems for the Treatment of Type 2 Diabetes Mellitus: An Available Administration Strategy for Antidiabetic Phytocompounds</p>

Nie¹,

Chen²,

Pang³

et al. 2020

IJN

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In view of the worldwide serious health threat of type 2 diabetes mellitus (T2DM), natural sources of chemotherapies have been corroborated as the promising alternatives, with the excellent antidiabetic activities, bio-safety, and more cost-effective properties. However, their clinical application is somewhat limited, because of the poor solubility, instability in the gastrointestinal tract (GIT), low bioavailability, and so on. Nowadays, to develop nanoscaled systems has become a prominent strategy to improve the drug delivery of phytochemicals. In this review, we primarily summarized the intervention mechanisms of phytocompounds against T2DM and presented the recent advances in various nanosystems of antidiabetic phytocompounds. Selected nanosystems were grouped depending on their classification and structures, including polymeric NPs, lipid-based nanosystems, vesicular systems, inorganic nanocarriers, and so on. Based on this review, the state-of-the-art nanosystems for phytocompounds in T2DM treatment have been presented, suggesting the preponderance and potential of nanotechnologies.

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Nano-Phytosome: A Developing Platform for Herbal Anti-Cancer Agents in Cancer Therapy

Abstract: Potential anti-cancer properties of phytoconstituents are enhanced by phytosomal formulations.

Cited by 85 publications

References 0 publications

Therapeutic benefits of rutin and its nanoformulations

Therapeutic benefits of rutin and its nanoformulations

Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells

<p>Oral Nano Drug Delivery Systems for the Treatment of Type 2 Diabetes Mellitus: An Available Administration Strategy for Antidiabetic Phytocompounds</p>

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