Nano Neurology and the Four P's of Central Nervous System Regeneration: Preserve, Permit, Promote, Plasticity

Ellis-Behnke, Rutledge

doi:10.1016/j.mcna.2007.04.005

Cited by 32 publications

(28 citation statements)

References 94 publications

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“…There are two main strategies to promote the self-repair of damaged axonal connections: re-growth of axons and/or re-organization of the neuronal circuit. Therefore, the conditions for the success of regeneration engineering are that firstly, the neurons must be preserved, in order to promote a permissive growth environment, and secondly, after re-connection, the plasticity of the tissue needs to be promoted (Ellis-Behnke 2007).…”

Section: Carbon Nanotubes For Neural Tissue Regenerationmentioning

confidence: 99%

Application of carbon nanotubes in neurology: clinical perspectives and toxicological risks

et al. 2012

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Nanomedicine is an emerging field that proposes the application of precisely engineered nanomaterials for the prevention, diagnosis and therapy of certain diseases, including neurological pathologies. Carbon nanotubes (CNT) are a new class of nanomaterials, which have been shown to be promising in different areas of nanomedicine. In this review, the application of CNT interfacing with the central nervous system (CNS) will be described, and representative examples of neuroprosthetic devices, such as neuronal implants and electrodes will be discussed. Furthermore, the possible application of CNT-based materials as regenerative matrices of neuronal tissue and as delivery systems for the therapy of CNS will be presented.

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Section: Carbon Nanotubes For Neural Tissue Regenerationmentioning

confidence: 99%

Application of carbon nanotubes in neurology: clinical perspectives and toxicological risks

et al. 2012

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“…Top: regenerative medicine for CNS recovery often follows the Four P. (Preserve, Permit, Promote, and Plasticity) as guidelines in developing novel nanomaterials (Ellis-Behnke, 2007). The importance of these guidelines depends on variables of treatment time and severity of injury, which contribute to themes of maximal cellular regeneration and minimal complication.…”

Section: A Gap Bridged By Nanomaterials For Peripheral and Central Nementioning

confidence: 99%

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

et al. 2016

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Nanomaterials have attracted the interest of tissue engineers for the last two decades. Their unique properties make them promising for de novo fabrication of bio-inspired hybrid/composite materials with improved regenerative properties, including, for example, the capacity for electric conductivity and the provision of antimicrobial properties. However, to this day, the use of such materials in medical applications is rather limited and most of the studies have only reached the archetypical proof-of-concept stage. Herein, we present a review on the use of nanomaterials in tissue engineering for regenerative therapies of heart, skin, eye, skeletal muscle, and nervous system. The advantages and limitations of nano-engineering materials are presented in this review alongside with the future challenges and milestones nanotechnology must overcome to make an impact in biomedical applications.

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“…These nanoengineered systems have the potential to contribute significantly to novel approaches for better understanding of the diagnosis and treatment of acute and chronic neurological CNS disorders [8]. The use of CNTs in drug delivery, detection, and tissue engineering has shown the potential to revolutionize medicine [133,138].…”

Section: Future Potential Applications Of Cntsmentioning

confidence: 99%

Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology

Komane

Choonara

Toit

et al. 2016

Journal of Nanomaterials

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Extensive research on carbon nanotubes has been conducted due to their excellent physicochemical properties. Based on their outstanding physicochemical properties, carbon nanotubes have the potential to be employed as theranostic tools for neurological pathologies such as Alzheimer’s disease and Parkinson’s disease including ischemic stroke diagnosis and treatment. Stroke is currently regarded as the third root cause of death and the leading source of immobility around the globe. The development and improvement of efficient and effective procedures for central nervous system disease diagnosis and treatment is necessitated. The main aim of this review is to discuss the application of nanotechnology, specifically carbon nanotubes, to the diagnosis and treatment of neurological disorders with an emphasis on ischemic stroke. Areas covered include the conventional current diagnosis and treatment of neurological disorders, as well as a critical review of the application of carbon nanotubes in the diagnosis and treatment of ischemic stroke, covering areas such as functionalization of carbon nanotubes and carbon nanotube-based biosensors. A broad perspective on carbon nanotube stimuli-responsiveness, carbon nanotube toxicity, and commercially available carbon nanotubes is provided. Potential future studies employing carbon nanotubes have been discussed, evaluating their extent of advancement in the diagnosis and treatment of neurological and ischemic disorders.

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Nano Neurology and the Four P's of Central Nervous System Regeneration: Preserve, Permit, Promote, Plasticity

Cited by 32 publications

References 94 publications

Application of carbon nanotubes in neurology: clinical perspectives and toxicological risks

Application of carbon nanotubes in neurology: clinical perspectives and toxicological risks

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology

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