Application of carbon nanotubes in neurology: clinical perspectives and toxicological risks

Nunes, António; Al‐Jamal, Khuloud T.; Nakajima, Takeshi; Hariz, Marwan; Kostarelos, Kostas

doi:10.1007/s00204-012-0860-0

Cited by 56 publications

(53 citation statements)

References 64 publications

(77 reference statements)

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“…Technological advancements in this area improved understanding of the effect of cellular damage on the CNS. The precision of neurological interventions and reduced invasiveness to the CNS have been enhanced to a greater extent [97]. The current technologies in CNS imaging include electroencephalography and magnetoencephalography.…”

Section: Carbon Nanotubes As Imaging Tools In Cns For Localization Anmentioning

confidence: 99%

See 1 more Smart Citation

Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology

Komane

Choonara

Toit

et al. 2016

Journal of Nanomaterials

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Extensive research on carbon nanotubes has been conducted due to their excellent physicochemical properties. Based on their outstanding physicochemical properties, carbon nanotubes have the potential to be employed as theranostic tools for neurological pathologies such as Alzheimer’s disease and Parkinson’s disease including ischemic stroke diagnosis and treatment. Stroke is currently regarded as the third root cause of death and the leading source of immobility around the globe. The development and improvement of efficient and effective procedures for central nervous system disease diagnosis and treatment is necessitated. The main aim of this review is to discuss the application of nanotechnology, specifically carbon nanotubes, to the diagnosis and treatment of neurological disorders with an emphasis on ischemic stroke. Areas covered include the conventional current diagnosis and treatment of neurological disorders, as well as a critical review of the application of carbon nanotubes in the diagnosis and treatment of ischemic stroke, covering areas such as functionalization of carbon nanotubes and carbon nanotube-based biosensors. A broad perspective on carbon nanotube stimuli-responsiveness, carbon nanotube toxicity, and commercially available carbon nanotubes is provided. Potential future studies employing carbon nanotubes have been discussed, evaluating their extent of advancement in the diagnosis and treatment of neurological and ischemic disorders.

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Section: Carbon Nanotubes As Imaging Tools In Cns For Localization Anmentioning

confidence: 99%

“…Neural tissue engineering contributes significantly to developing and improving biological scaffolds to promote neural tissue functioning [97]. Neural tissue engineering is a promising approach in recovery from neurodegenerative disorders including stroke.…”

Section: Carbon Nanotubes In Neuroengineering In Ischemic Stroke and mentioning

confidence: 99%

Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology

Komane

Choonara

Toit

et al. 2016

Journal of Nanomaterials

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“…A large number of CNS pathologies, in particular AD, PD, stroke, traumatic brain injury, and spinal cord injury may lead to failure of brain and spinal cord cells. 28 The two most important approaches to promoting self-repair of damaged axonal connections are regrowth of axons and/or reorganization of the neuronal circuitry. Therefore, the requirements for successful regenerative …”

Section: Cnts In Neuroregenerationmentioning

confidence: 99%

Carbon nanotubes and graphene as emerging candidates in neuroregeneration and neurodrug delivery

John¹,

Subramanian²,

Vellayappan³

et al. 2015

IJN

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Neuroregeneration is the regrowth or repair of nervous tissues, cells, or cell products involved in neurodegeneration and inflammatory diseases of the nervous system like Alzheimer’s disease and Parkinson’s disease. Nowadays, application of nanotechnology is commonly used in developing nanomedicines to advance pharmacokinetics and drug delivery exclusively for central nervous system pathologies. In addition, nanomedical advances are leading to therapies that disrupt disarranged protein aggregation in the central nervous system, deliver functional neuroprotective growth factors, and change the oxidative stress and excitotoxicity of affected neural tissues to regenerate the damaged neurons. Carbon nanotubes and graphene are allotropes of carbon that have been exploited by researchers because of their excellent physical properties and their ability to interface with neurons and neuronal circuits. This review describes the role of carbon nanotubes and graphene in neuroregeneration. In the future, it is hoped that the benefits of nanotechnologies will outweigh their risks, and that the next decade will present huge scope for developing and delivering technologies in the field of neuroscience.

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“…Nanotechnology is an emerging field; in particular, applications of precisely engineered nanomaterials in neuroscience have been proposed [1]. Regarding the properties of these tissues, a neural interface with nanoscale components is more suitable than that with microscale devices [2].…”

Section: Introductionmentioning

confidence: 99%

Effects of Injection of Carbon Nanotubes on EEG and Results of a Behavioral Test in Rats

et al. 2015

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We examined the biocompatibility of carbon nanotubes (CNTs) injected i.p. into rats (1 mg/kg body mass) by recording EEG from the frontal and occipital cortex and performing the water maze router test before and after such injection. For EEG, the energy and average power spectral density of wavelet coefficients in the β, α, and θ bands were considered the features. In the water maze router experiment, the distance, time, and speed of rats were investigated as behavioral factors. Comparison of EEG signals before and after injection showed that introduction of CNTs exerted no significant effect on electrophysiological brain indices. A comparison of behavioral factors before and after injection, however, showed that injections of CNTs increased the pacing distance and time to find the desired platform and decreased somewhat the speed in the water maze router experiment. A possible reason of this phenomenon is the possible influence of CNTs on ion fluxes in brain neurons.

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Application of carbon nanotubes in neurology: clinical perspectives and toxicological risks

Cited by 56 publications

References 64 publications

Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology

Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology

Carbon nanotubes and graphene as emerging candidates in neuroregeneration and neurodrug delivery

Effects of Injection of Carbon Nanotubes on EEG and Results of a Behavioral Test in Rats

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