Nano intervention in topical delivery of corticosteroid for psoriasis and atopic dermatitis—a systematic review

Abstract

Atopic dermatitis (AD) and psoriasis are highly prevalent, complex, chronic inflammatory skin diseases that immensly affect the patient’s quality of life. While there is no definitive cure for these conditions, suppressive medications aim at managing the symptoms of these diseases. The application of emollients accompanied by symptomatic anti-inflammatory therapy consisting of topical corticosteroids (TCS) is extensively employed for controlling the symptoms among general practitioners making this therapeutic class an indispensable pillar of dermatotherapeutics. The first TCS, hydrocortisone (HC) introduced in the early 1950s led to the development of different steroidal moieties of varying potencies by inducing chemical modifications to the basic steroid structure. The wide spectrum of the available range of formulations and potency provides flexibility to treat all patient groups, different phases of the diseases, and different anatomical sites. Conventional TCS therapy suffers from drawbacks such as low drug permeation and retention rate. Thus, novel nanoformulations have been developed to overcome these problems. This review provides an insight into the current state of nanocarrier-mediated topical delivery of corticosteroids monotherapy and combination therapy with special emphasis on targeting psoriasis and AD.

The application of corticosteroids for pathological scar prevention and treatment: current review and update

“…Among the nanocarrier systems, nanoliposomes with phospholipid membrane structures and transformers have been studied extensively and have been certified to penetrate the stratum corneum barrier into the dermis layer through deformation, proving to be excellent carriers for transdermal drug delivery [ 65 ]. At present, nanocarrier systems loaded with corticosteroids are predominately used for the treatment of psoriasis, atopic dermatitis and other skin diseases [ 66 , 67 ]. In comparison with commercially available creams, liposomal gel loaded with mometasone furoate displays a 15.21-fold increase in skin permeability [ 68 ].…”

Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders

“…Lipid carriers attach to the surface of the skin and support the lipid exchange between the outermost layers of the SC. [114,115] Archeosomes Consisted of archebacteria lipids, chemically distinct from eukaryotic and prokaryotic species. Less sensitive to high temperature, alkaline pH, and oxidative stress.…”

Rapidly Dissolving Microneedles for the Delivery of Steroid-Loaded Nanoparticles Intended for the Treatment of Inflammatory Skin Diseases

“…Topical corticosteroids are one of the most widely used treatment modalities for inflammatory skin diseases. They are considered the first-line treatment because of their therapeutic potential, being vasoconstrictors, anti-inflammatory, immunosuppressive, and anti-proliferative drugs [ 13 , 14 ]. Topical corticosteroids can be formulated in different dosage forms, such as creams, ointment, and lotions.…”