Nano Gold and Biomedicine: Scientific Letter

Tan, Gamze; Onur, Mehmet Alį; Sağlam, Necdet

doi:10.5336/medsci.2010-21147

Cited by 2 publications

(1 citation statement)

References 53 publications

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“…Gold‐coated MNPs are used in antibody binding, gene transfer, and antisense therapy. When gold‐coated MNPs carry molecules in the body, they increase the stability, bioavailability, and survival of molecules [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Treatment of tumour tissue with radio‐frequency hyperthermia (using antibody‐carrying nanoparticles)

Didarian

Vargel

2021

IET Nanobiotechnology

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Intelligent inorganic nanoparticles were designed and produced for use in imaging and annihilating tumour cells by radio-frequency (RF) hyperthermia. Nanoparticles synthesised to provide RF hyperthermia must have magnetite properties. For this purpose, magnetite nanoparticles were first synthesised by the coprecipitation method (10-15 NM). These superparamagnetic nanoparticles were then covered with gold ions without losing their magnetic properties. In this step, gold ions are reduced around the magnetite nanoparticles. Surface modification of the gold-coated magnetic nanoparticles was performed in the next step. A self-assembled monolayer was created using cysteamine (2-aminoethanethiol) molecules, which have two different end groups (SH and NH 2 ). These molecules react with the gold surface by SH groups. The NH 2 groups give a positive charge to the nanoparticles. After that, a monoclonal antibody (Monoclonal Anti-N-CAM Clone NCAM-OB11) was immobilised by the 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/N-hydroxysuccinimide method. Then, the antenna RF system (144.00015 MHz) was created for RF hyperthermia. The antibody-nanoparticle binding rate and cytotoxicity tests were followed by in vitro and in vivo experiments. As the main result, antibody-bound gold-coated magnetic nanoparticles were successfully connected to tumour cells. After RF hyperthermia, the tumour size decreased owing to apoptosis and necrosis of tumour cells.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Introductionmentioning

confidence: 99%

Treatment of tumour tissue with radio‐frequency hyperthermia (using antibody‐carrying nanoparticles)

Didarian

Vargel

2021

IET Nanobiotechnology

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A Comprehensive Investigation on Tribological Performance of Nano-Silver and Nano-Gold Additivated Fluids on Wearing Surfaces

Korkmaz

Çetin

Dogan

et al. 2020

Journal of Tribology

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In this study, the tribological performances of the colloidal suspensions with the additives of nano-silver and nano-gold were examined via wear experiments of AA7075-T6 material. The nanoparticles were penetrated in the wear region using suspensions prepared in distilled water and ethylene glycol environment. The wear experiments were performed under 30 N load and 20 rpm speed condition in 1000 m wear distance using the ball-on-plate method. The worn surfaces were analyzed with a three-dimensional profilometer, scanning electron microscope/energy-dispersive X-ray (EDX), and atomic force microscope (AFM) methods. According to the results, the colloidal dispersed nano-gold particles in ethylene glycol performed 28.85% better on reducing the surface roughness, 2.32% on reducing the weight loss, 4.85% on increasing the heat transfer, and 1.22% on reducing the friction coefficient than the nano-silver particles.

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Nano Gold and Biomedicine: Scientific Letter

Cited by 2 publications

References 53 publications

Treatment of tumour tissue with radio‐frequency hyperthermia (using antibody‐carrying nanoparticles)

Treatment of tumour tissue with radio‐frequency hyperthermia (using antibody‐carrying nanoparticles)

A Comprehensive Investigation on Tribological Performance of Nano-Silver and Nano-Gold Additivated Fluids on Wearing Surfaces

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