2018
DOI: 10.1186/s41120-018-0025-1
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Nano-formulations composed of cell membrane-specific cellular lipid extracts derived from target cells: physicochemical characterization and in vitro evaluation using cellular models of breast carcinoma

Abstract: Highly selective drug targeting is an important goal in the development of cancer nanotechnologies. In an effort to improve tumor targeting a method was developed to formulate cell membrane lipid-extracted nanoliposomes (CLENs). The main ingredients were extracted directly from the membrane of cancer cells. For this study we used three different breast cancer cell lines (4 T1, BT-20, and SK-BR-3). As controls for the normal breast and cancer tissue environments we employed the normal breast fibroblast (CRL-208… Show more

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Cited by 4 publications
(7 citation statements)
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“…21 Cellular membrane lipid-extracted nanoliposomes (CLENs) are also an option, using cellular-derived lipids that enhance target tissue specificity. 22 The lipid extract used to create CLENs are derived from the intended target cell, and thus should resemble the target cell membrane. 22 This resemblance provides improved recognizance of the nano-delivery system by the target cell population resulting in enhanced uptake when compared to conventional liposomes.…”
Section: Effective Treatment Approachmentioning
confidence: 99%
See 3 more Smart Citations
“…21 Cellular membrane lipid-extracted nanoliposomes (CLENs) are also an option, using cellular-derived lipids that enhance target tissue specificity. 22 The lipid extract used to create CLENs are derived from the intended target cell, and thus should resemble the target cell membrane. 22 This resemblance provides improved recognizance of the nano-delivery system by the target cell population resulting in enhanced uptake when compared to conventional liposomes.…”
Section: Effective Treatment Approachmentioning
confidence: 99%
“…22 The lipid extract used to create CLENs are derived from the intended target cell, and thus should resemble the target cell membrane. 22 This resemblance provides improved recognizance of the nano-delivery system by the target cell population resulting in enhanced uptake when compared to conventional liposomes. 22 Solid lipid nanoparticles (SLN) can incorporate both hydrophilic and lipophilic drugs while delivering the drug in a controlled manner.…”
Section: Effective Treatment Approachmentioning
confidence: 99%
See 2 more Smart Citations
“…Niosome technology is a novel microparticle preparation method based on liposomes. Non-ionic surfactant niosomes use non-ionic surfactants to ensure that the vesicle excipients are structured as bilayers to encapsulate pharmaceuticals, and the number of structural layers of niosomes can be modified to encapsulate multiple pharmaceutical ingredients [20,21]. The special excipients of non-ionic surfactant vesicles can encapsulate both hydrophilic and lipophilic drugs, enhance their synergism, stabilize their curative effect, improve patient compliance, and avoid the oxidative decomposition issues related to phospholipid molecules [22].…”
Section: Introductionmentioning
confidence: 99%