Nano formulated Resveratrol inhibits metastasis and angiogenesis by reducing inflammatory cytokines in oral cancer cells by targeting tumor associated macrophages

Pradhan, Rajalaxmi; Chatterjee, Subhajit; Hembram, Krushna Chandra; Sethy, Chinmayee; Mandal, Mahitosh; Kundu, Chanakya Nath

doi:10.1016/j.jnutbio.2021.108624

Cited by 58 publications

(31 citation statements)

References 35 publications

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“…Pradhan et al [ 359 ] coined the concept of angioprevention, pointing out the capacity of dietary phytochemicals, including resveratrol, to inhibit inflammation and angiogenesis. Together with the resveratrol-mediated suppression of NF-κB, resveratrol reduces the expression of inflammatory cytokines, such as IL-1, -6, -8, TNF-α, and VEGF as well [ 359 ]. In addition, numerous studies have shown that resveratrol suppresses the activation of MAPK signaling pathways.…”

Section: Antitumor Activity Of Propolis and Its Polyphenolic/flavonoi...mentioning

confidence: 99%

Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

Oršolić

Jembrek

2022

IJMS

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In recent years, interest in natural products such as alternative sources of pharmaceuticals for numerous chronic diseases, including tumors, has been renewed. Propolis, a natural product collected by honeybees, and polyphenolic/flavonoid propolis-related components modulate all steps of the cancer progression process. Anticancer activity of propolis and its compounds relies on various mechanisms: cell-cycle arrest and attenuation of cancer cells proliferation, reduction in the number of cancer stem cells, induction of apoptosis, modulation of oncogene signaling pathways, inhibition of matrix metalloproteinases, prevention of metastasis, anti-angiogenesis, anti-inflammatory effects accompanied by the modulation of the tumor microenvironment (by modifying macrophage activation and polarization), epigenetic regulation, antiviral and bactericidal activities, modulation of gut microbiota, and attenuation of chemotherapy-induced deleterious side effects. Ingredients from propolis also ”sensitize“ cancer cells to chemotherapeutic agents, likely by blocking the activation of the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). In this review, we summarize the current knowledge related to the the effects of flavonoids and other polyphenolic compounds from propolis on tumor growth and metastasizing ability, and discuss possible molecular and cellular mechanisms involved in the modulation of inflammatory pathways and cellular processes that affect survival, proliferation, invasion, angiogenesis, and metastasis of the tumor.

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Section: Antitumor Activity Of Propolis and Its Polyphenolic/flavonoi...mentioning

confidence: 99%

Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

Oršolić

Jembrek

2022

IJMS

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“…A combination of Res and RAD51-siRNA induces apoptosis in HeLa cells and prevents cervical cancer progression [ 363 ]. Overall, experiments reveal role of Res in suppressing CSCs in cancer progression ( Figure 6 , Table 7 ) [ 364 , 365 , 366 , 367 ].…”

Section: Dietary Agents and Cancer Stem Cellsmentioning

confidence: 99%

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

Paskeh

Asadi²,

Zabolian

et al. 2021

IJMS

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As a multifactorial disease, treatment of cancer depends on understanding unique mechanisms involved in its progression. The cancer stem cells (CSCs) are responsible for tumor stemness and by enhancing colony formation, proliferation as well as metastasis, and these cells can also mediate resistance to therapy. Furthermore, the presence of CSCs leads to cancer recurrence and therefore their complete eradication can have immense therapeutic benefits. The present review focuses on targeting CSCs by natural products in cancer therapy. The growth and colony formation capacities of CSCs have been reported can be attenuated by the dietary agents. These compounds can induce apoptosis in CSCs and reduce tumor migration and invasion via EMT inhibition. A variety of molecular pathways including STAT3, Wnt/β-catenin, Sonic Hedgehog, Gli1 and NF-κB undergo down-regulation by dietary agents in suppressing CSC features. Upon exposure to natural agents, a significant decrease occurs in levels of CSC markers including CD44, CD133, ALDH1, Oct4 and Nanog to impair cancer stemness. Furthermore, CSC suppression by dietary agents can enhance sensitivity of tumors to chemotherapy and radiotherapy. In addition to in vitro studies, as well as experiments on the different preclinical models have shown capacity of natural products in suppressing cancer stemness. Furthermore, use of nanostructures for improving therapeutic impact of dietary agents is recommended to rapidly translate preclinical findings for clinical use.

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“…Resveratrol effectively reverses IL‐6‐induced migratory movements by inhibiting migration stimulated by CAFs and by reducing IL‐6 biosynthesis in cancer cells (Thongchot et al, 2018). Nano‐formulated resveratrol can reduce the invasion of oral cancer by inhibiting the secretion of cytokines such as IL‐6 by tumor‐associated macrophages, according to a study of oral cancer cells (Pradhan et al, 2021). In summary, resveratrol can block IL‐6 upstream and reduce IL‐6 secretion by targeting tumor‐associated immune cells, and it can also block IL‐6 downstream signaling pathways, effectively stopping cancer cell invasion.…”

Section: Phenolic Compounds That Mediate the Effects Of Il‐6 On Tumorsmentioning

confidence: 99%

Research progress of phenolic compounds regulating IL‐6 to exert antitumor effects

Xia

Ren

et al. 2021

Phytotherapy Research

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Cytokine therapy, which activates the host immune system, has become an important and novel therapeutic approach to treat various cancers. Recent studies have shown that IL-6 is an important cytokine that regulates the homeostasis in vivo. However, excessive IL-6 plays a pathological role in a variety of acute and chronic inflammatory diseases, especially in cancer. IL-6 can transmit signals through JAK/STAT, RAS /MAPK, PI3K/ Akt, NF-κB, and other pathways to promote cancer progression. Phenolic compounds can effectively regulate the level of IL-6 in tumor cells and improve the tumor microenvironment. This article focuses on the phenolic compounds through the regulation of IL-6, participate in the prevention of cancer, inhibit the proliferation of cancer cells, reduce angiogenesis, improve therapeutic efficacy, and reduce side effects and other aspects. This will help to further advance research on cytokine therapy to reduce the burden of cancer and improve patient prognosis.However, current studies are mostly limited to animal and cellular experiments, and high-quality clinical studies are needed to further determine their antitumor efficacy in humans.

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Nano formulated Resveratrol inhibits metastasis and angiogenesis by reducing inflammatory cytokines in oral cancer cells by targeting tumor associated macrophages

Cited by 58 publications

References 35 publications

Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

Research progress of phenolic compounds regulating IL‐6 to exert antitumor effects

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