Nano-enabled topical delivery of anti-psoriatic small molecules

Bhat, Medha; Pukale, Sudeep Sudesh; Singh, Saurabh; Mittal, Anupama

doi:10.1016/j.jddst.2021.102328

Cited by 13 publications

(10 citation statements)

References 187 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…22 Nonetheless, this treatment possesses several limitations, including inadequate and unpredictable delivery to the afflicted skin as well as local toxicity due to skin irritation. 22,23 Biologic drugs (biologics or biologic agents) are the recent treatment strategy with superior efficacy to other treatments for moderate to severe type of psoriasis. 3,24 This treatment employs recombinant proteins to inhibit inammatory cytokines at the target site while functions systemically.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects

et al. 2021

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…22 Nonetheless, this treatment possesses several limitations, including inadequate and unpredictable delivery to the afflicted skin as well as local toxicity due to skin irritation. 22,23…”

Section: Introductionmentioning

confidence: 99%

Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Currently, the market is flooded with conventional TCS preparations extensively used for psoriasis and AD. The use of current TCS therapy for dermatological conditions are inadequate because of their local and systemic toxicity, low benefit-to-risk ratio, reduced treatment efficacy (due to lower penetration of active in the viable epidermal region and poor retentive capability), and high dosing frequency with poor patient compliance [ 124 ]. Developments in nanotechnology-based drug delivery have successfully opened avenues for improved drug targeting, better therapeutic value, and reduced toxicity for transdermal therapy of psoriasis and AD.…”

Section: Discussionmentioning

confidence: 99%

Nano intervention in topical delivery of corticosteroid for psoriasis and atopic dermatitis—a systematic review

Shetty

Sherje

2021

J Mater Sci: Mater Med

View full text Add to dashboard Cite

Atopic dermatitis (AD) and psoriasis are highly prevalent, complex, chronic inflammatory skin diseases that immensly affect the patient’s quality of life. While there is no definitive cure for these conditions, suppressive medications aim at managing the symptoms of these diseases. The application of emollients accompanied by symptomatic anti-inflammatory therapy consisting of topical corticosteroids (TCS) is extensively employed for controlling the symptoms among general practitioners making this therapeutic class an indispensable pillar of dermatotherapeutics. The first TCS, hydrocortisone (HC) introduced in the early 1950s led to the development of different steroidal moieties of varying potencies by inducing chemical modifications to the basic steroid structure. The wide spectrum of the available range of formulations and potency provides flexibility to treat all patient groups, different phases of the diseases, and different anatomical sites. Conventional TCS therapy suffers from drawbacks such as low drug permeation and retention rate. Thus, novel nanoformulations have been developed to overcome these problems. This review provides an insight into the current state of nanocarrier-mediated topical delivery of corticosteroids monotherapy and combination therapy with special emphasis on targeting psoriasis and AD.

show abstract

“…Traditionally known as liposomes, lipopolymers, solid lipid nanoparticles, nanostructured lipid nanoparticles, microemulsions and nanoemulsions, lipid nanoparticles are used primarily for the release of small molecules, peptides, genes and monoclonal antibodies [72]. Liposomes consist of spherical vesicles having one or more lipid layers containing an aqueous core.…”

Section: Liposomesmentioning

confidence: 99%

Perspective Chapter: Liposome Mediated Delivery of Immunotherapeutics for Cancer

Iscaro¹,

Howard²,

Yang³

et al. 2023

Liposomes - Recent Advances, New Perspectives and Applications

View full text Add to dashboard Cite

Tumors have complex properties that depend on interactions between epithelial cancer cells and the surrounding stromal compartment within the tumor microenvironment. In particular, immune infiltration plays a role in controlling tumor development and is now considered one of the hallmarks of cancer. The last few years has seen an explosion in immunotherapy as a targeted strategy to fight cancer without damaging healthy cells. In this way, long-lasting results are elicited by activation of an antitumor immune response, utilizing the body’s own surveillance mechanisms to reprogram the tumour microenvironment. The next challenge is to ensure targeted delivery of these therapies for increased efficacy and reduction in immune-related adverse events. Liposomes are an attractive drug delivery system providing versatility in their formulation including material type, charge, size and importantly surface chemical modifications that confer their tumour specificity. These tunable properties make them an attractive platform for the treatment of cancer. In this chapter, we will discuss clinically approved immunotherapies and those undergoing clinical trials together with, recent liposomal approaches for enhanced specificity and efficacy.

show abstract

Nano-enabled topical delivery of anti-psoriatic small molecules

Cited by 13 publications

References 187 publications

Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects

Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects

Nano intervention in topical delivery of corticosteroid for psoriasis and atopic dermatitis—a systematic review

Perspective Chapter: Liposome Mediated Delivery of Immunotherapeutics for Cancer

Contact Info

Product

Resources

About