Nano-enabled colorectal cancer therapy

Pan, Qingqing; Fan, Xi; Xie, Li; Wu, Di; Liu, Rong; Gao, Wenxia; Luo, Kui; He, Bin; Pu, Yuji

doi:10.1016/j.jconrel.2023.09.014

Cited by 9 publications

(5 citation statements)

References 141 publications

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“…CRC recurrence and metastasis significantly affect the prognosis of patients [40]. Current CRC treatment encounters challenges related to poor tolerance and severe side effects [7]. Therefore, prioritizing the development of methods that can effectively prevent, treat, and mitigate toxicity and side effects is imperative.…”

Section: Discussionmentioning

confidence: 99%

“…Recent years have witnessed considerable advancements in traditional chemotherapy, radiotherapy, and targeted therapy for CRC. However, the prognosis for advanced CRC is unfavorable, and current treatment methods are ineffective in preventing cancer recurrence and metastasis, attributed to conditions such as drug resistance and low response rate [6,7]. Natural active ingredients in plants, such as anthocyanins, have the advantages of low cytotoxicity and strong antioxidant activity, and play a useful role in the prevention and relief of CRC [8].…”

Section: Introductionmentioning

confidence: 99%

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Hawthorn Proanthocyanidin Extract Inhibits Colorectal Carcinoma Metastasis by Targeting the Epithelial-Mesenchymal Transition Process and Wnt/β-Catenin Signaling Pathway

Wang,

Sun,

et al. 2024

Foods

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Colorectal carcinoma (CRC) is a major global health concern, with cancer metastasis being the main cause of patient mortality, and current CRC treatments are challenged by drug resistance. Although natural compounds, especially in foods like hawthorn proanthocyanidin extract (HPOE), have good anticancer activity, their effects on CRC metastasis remain unknown. Therefore, our objective was to investigate the impact and potential mechanisms of HPOE on the movement and infiltration of cells in the HCT116 CRC cells. Firstly, scratch-healing experiments confirmed the anti-migratory and anti-invasive capabilities of HPOE. Then, network pharmacology identified 16 possible targets, including MMP-9. Subsequently, RT-qPCR and Western blotting experiments confirmed that HPOE downregulated epithelial-mesenchymal transition-related factors (N-cadherin and MMP-9) and inhibited Wnt/β-catenin pathway activation. Finally, these results were experimentally validated using the Wnt pathway activator Licl and inhibitor XAV939. It was confirmed that HPOE had a certain inhibitory effect on the activation of the Wnt signaling pathway caused by the activator Licl and could enhance the inhibitory effect of the inhibitor XAV939. Our findings provide a basis for developing functional foods or dietary supplements, especially positioning HPOE as a functional food raw material for adjuvant treatment of CRC, given its ability to inhibit metastasis through the Wnt/β-catenin pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hawthorn Proanthocyanidin Extract Inhibits Colorectal Carcinoma Metastasis by Targeting the Epithelial-Mesenchymal Transition Process and Wnt/β-Catenin Signaling Pathway

Wang,

Sun,

et al. 2024

Foods

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“…Tumor recurrence following surgical intervention and the significant adverse effects associated with systemic chemotherapy pose inevitable challenges in the management of solid tumors [ 23 , 24 ]. The present study reported the fabrication of GEM and CDDP-loaded nanocomposites using electrospinning technology.…”

Section: Discussionmentioning

confidence: 99%

Electrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironment

Wang,

Yin,

Ren

et al. 2024

J Mater Sci: Mater Med

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The perplexing issues related to positive surgical margins and the considerable negative consequences associated with systemic chemotherapy have posed ongoing challenges for clinicians, especially when it comes to addressing bladder cancer treatment. The current investigation describes the production of nanocomposites loaded with gemcitabine (GEM) and cisplatin (CDDP) through the utilization of electrospinning technology. In vitro and in vivo studies have provided evidence of the strong effectiveness in suppressing tumor advancement while simultaneously reducing the accumulation of chemotherapy drugs within liver and kidney tissues. Mechanically, the GEM and CDDP-loaded electrospun nanocomposites could effectively eliminate myeloid-derived suppressor cells (MDSCs) in tumor tissues, and recruit CD8+ T cells and NKp46+ NK cells to kill tumor cells, which can also effectively inhibit tumor microvascular formation. Our investigation into the impact of localized administration of chemotherapy through GEM and CDDP-loaded electrospun nanocomposites on the tumor microenvironment will offer novel insights for tackling tumors. Graphical abstract

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“…Innovative DDSs, including nanoparticle-and hydrogel-based formulations, have demonstrated superior anti-tumor e cacy with fewer adverse effects 9,11,12 . Furthermore, overcoming CRC's inherent drug resistance through combined chemotherapy with novel therapeutic modalities represents a promising avenue 13 . For instance, Zhu et al constructed a dual drug delivery nanoenzyme and demonstrated the synergistic treatment of CRC by nanoenzyme's dual chemotherapy and photothermal therapy (PTT) using subcutaneous and orthotopic CRC models 14 .…”

Section: Introductionmentioning

confidence: 99%

A Hollow-Tube-Like Hydrospongel for Magnetothermal-Chemo-Chemodynamic Therapies in Advanced Colorectal Cancer Patients

Wang,

Wu,

et al. 2024

Preprint

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In advanced-stage colorectal cancer (CRC) treatments, preserving anal function presents significant challenges. This study introduces a novel hollow-tube-like hydrospongel (HTHSG), offering a groundbreaking approach to neoadjuvant therapy. Constructed from cellulose nanofibers crosslinked with Fe3O4@PDA nanoparticles, the HTHSG combines the rapid swelling characteristics of sponges (~ 10 seconds) with the robust fracture strength of hydrogels (> 250 kPa). Its unique design ensures stability and location retention during simulated bowel movements, facilitating precise, localized delivery of the chemotherapeutic agent 5-FU directly to the tumor site. Beyond conventional chemotherapy, the HTHSG leverages electromagnetic induction for targeted thermal ablation and chemodynamic therapy, significantly minimizing the collateral damage to healthy tissues typically associated with Fe-mediated Fenton reactions. Comparative analyses using cell-derived and patient-derived xenograft models highlight the HTHSG's superior efficacy in tumor reduction based on traditional neoadjuvant therapies. These findings suggest the HTHSG's potential to redefine standard pre-surgical treatment regimens for advanced-stage CRC patients, marking a significant advancement over existing chemotherapy approaches.

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Nano-enabled colorectal cancer therapy

Cited by 9 publications

References 141 publications

Hawthorn Proanthocyanidin Extract Inhibits Colorectal Carcinoma Metastasis by Targeting the Epithelial-Mesenchymal Transition Process and Wnt/β-Catenin Signaling Pathway

Hawthorn Proanthocyanidin Extract Inhibits Colorectal Carcinoma Metastasis by Targeting the Epithelial-Mesenchymal Transition Process and Wnt/β-Catenin Signaling Pathway

Electrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironment

A Hollow-Tube-Like Hydrospongel for Magnetothermal-Chemo-Chemodynamic Therapies in Advanced Colorectal Cancer Patients

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