Nano drug delivery in oral cancer therapy: An emerging avenue to unveil

Dathar, Sahithi; Dental, Vishnu

doi:10.15713/ins.jmrps.31

Cited by 10 publications

(10 citation statements)

References 39 publications

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“…Furthermore, their high stability provides controlled drug release, drug protection from chemical degradation, and they can serve as carriers for drugs with low aqueous solubility [92,117]. Therefore, these nanoparticles seem suitable for local delivery of drugs and chemopreventive agents [118,119].…”

Section: Carriers For Oscc Drug Delivery Systemsmentioning

confidence: 99%

Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives

et al. 2019

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Oral squamous cell carcinoma (OSCC), which encompasses the oral cavity-derived malignancies, is a devastating disease causing substantial morbidity and mortality in both men and women. It is the most common subtype of the head and neck squamous cell carcinoma (HNSCC), which is ranked the sixth most common malignancy worldwide. Despite promising advancements in the conventional therapeutic approaches currently available for patients with oral cancer, many drawbacks are still to be addressed; surgical resection leads to permanent disfigurement, altered sense of self and debilitating physiological consequences, while chemo- and radio-therapies result in significant toxicities, all affecting patient wellbeing and quality of life. Thus, the development of novel therapeutic approaches or modifications of current strategies is paramount to improve individual health outcomes and survival, while early tumour detection remains a priority and significant challenge. In recent years, drug delivery systems and chronotherapy have been developed as alternative methods aiming to enhance the benefits of the current anticancer therapies, while minimizing their undesirable toxic effects on the healthy non-cancerous cells. Targeted drug delivery systems have the potential to increase drug bioavailability and bio-distribution at the site of the primary tumour. This review confers current knowledge on the diverse drug delivery methods, potential carriers (e.g., polymeric, inorganic, and combinational nanoparticles; nanolipids; hydrogels; exosomes) and anticancer targeted approaches for oral squamous cell carcinoma treatment, with an emphasis on their clinical relevance in the era of precision medicine, circadian chronobiology and patient-centred health care.

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Section: Carriers For Oscc Drug Delivery Systemsmentioning

confidence: 99%

Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives

et al. 2019

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“…Lengthy and expensive diagnostic strategies often lack the ability to efficiently differentiate between normal and tumor tissue, which could delay the initiation of treatment. In addition, the traditional treatment of oral cancer, such as surgery, radiotherapy, and chemotherapy, has certain limitations and side effects [ 5 ]. Thus, it is crucial to increase the effectiveness of diagnosis and reduce the side effects of treatment.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles for Oral Cancer Diagnosis and Therapy

Zheng

Zhou

Yuan

2021

Bioinorganic Chemistry and Applications

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Oral cancer is the sixth most common malignant cancer, affecting the health of people with an unacceptably high mortality rate. Despite numerous clinical methods in the diagnosis and therapy of oral cancer (e.g., magnetic resonance imaging, computed tomography, surgery, and chemoradiotherapy), they still remain far from optimal. Therefore, an urgent need exists for effective and practical techniques of early diagnosis and effective therapy of oral cancer. Currently, various types of nanoparticles have aroused wide public concern, representing a promising tool for diagnostic probes and therapeutic devices. Their inherent physicochemical features, including ultrasmall size, high reactivity, and tunable surface modification, enable them to overcome some of the limitations and achieve the expected diagnostic and therapeutic effect. In this review, we introduce different types of nanoparticles that emerged for the diagnosis and therapy of oral cancers. Then, the challenges and future perspectives for nanoparticles applied in oral cancer diagnosis and therapy are presented. The objective of this review is to help researchers better understand the effect of nanoparticles on oral cancer diagnosis and therapy and may accelerate breakthroughs in this field.

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“…It is achieved through delivery systems, which help in delivering or carrying the drug to the specified site. The various delivery systems used are nanotubes, nanowires, nano shells, quantum dots, gold nano, dendrimers niosomes virosomes, liposomes, nanocrystals, magnetic nanoparticles, nanorobots 8 . Nano tubes are the hollow cylinder tubes made of carbon atoms, which can be filled and sealed for potential drug delivery they measure about 10 to 100 micrometers 9,10 .…”

Section: Delivery Systemsmentioning

confidence: 99%

“…Nanowires are the thin wires which are usually microns in size, they localize the pinpoint damaged site. It has its wide applicating in patients with neurological disorders 8 . Nanoshells are the hollow silica spheres, covered with gold.…”

Section: Delivery Systemsmentioning

confidence: 99%

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Targeted Local Drug Delivery – A Possible Approach in Dentistry

2020

IJPHRD

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Drug delivery is a method of administering a pharmaceutical compound to achieve a therapeutic effect in humans and animals. Conventional therapy is a classical method of achieving drug delivery. Where, it provides drug release immediately and causes fluctuation of drug level in in blood depending on the dosage forms compared to conventional, which improves the drug potency, controlled drug release to give a sustained therapeutic effect, provide greater safety and target a drug specifically to a desired tissue. It mainly includes targeted, controlled and modulated drug delivery systems. Hence, there is an increased interest towards the application of targeted therapies in medicine and dentistry and has proven to be successful in prevention and treatment of various oro-dental disorders.

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Nano drug delivery in oral cancer therapy: An emerging avenue to unveil

Cited by 10 publications

References 39 publications

Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives

Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives

Nanoparticles for Oral Cancer Diagnosis and Therapy

Targeted Local Drug Delivery – A Possible Approach in Dentistry

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