Nano drug delivery in intracellular bacterial infection treatments

Hosseini, Seyed Mostafa; Taheri, Mohammad; Nouri, Fatemeh; Farmani, Abbas; Moez, Narjes Morovati; Arabestani, Mohammad Reza

doi:10.1016/j.biopha.2021.112609

Cited by 27 publications

(25 citation statements)

References 135 publications

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“…Trace elements are vital components of the human immune system. Enzymes and hormones need a minimal amount of trace elements for their function as small fluctuations in trace element levels cause a negative impact on their function [12,23]. This makes the body weak against microorganisms, and as a result, the immune system's ability to fight disease is weakened.…”

Section: Discussionmentioning

confidence: 99%

Codelivery of Doxycycline and Hydroxychloroquine to Treatment of Brucellosis: An Animal Study

Hosseini

Farmany

Alikhani

et al. 2022

Journal of Nanomaterials

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Evaluation of various biochemical and immunological parameters in infectious diseases is one of the best indicators for a diagnosis and treatment process. The main goal of this project is to determine the effect of hydroxychloroquine and doxycycline loading into solid-lipid-nanoparticles (DOX-HCQ-SLN) on the both acute and chronic phases of brucellosis. In addition, evaluate some biochemical factors, trace elements, and inflammatory elements. Blood serum levels of Zn, Fe, Na, and K and hepatic biochemical parameters (AST, ALT, ALP, and TBil) were remarkably different between infected and healthy rats. Vitamin D was decreased, and CRP was increased in chronic and acute brucellosis. Quantitative evaluation of these mentioned parameters can be useful to diagnose brucellosis in advance. Due to the good effect of the synchronized use of hydroxychloroquine and doxycycline in the form of nanoparticles, the manipulation of these nanoparticles can help for better treatment and also reduction in brucellosis reinfection.

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Section: Discussionmentioning

confidence: 99%

Codelivery of Doxycycline and Hydroxychloroquine to Treatment of Brucellosis: An Animal Study

Hosseini

Farmany

Alikhani

et al. 2022

Journal of Nanomaterials

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“…CuI NPs (in size range of 1−100 nm) can induce bacterial death through ROS production and lipids peroxidation. 19 Pramanik et al synthesized (by co-precipitation) copper iodide (CuI) NPs with an average particle size of 8 nm and average charge of −21.5 mV. Studies revealed that CuI NPs generated ROS in both Gram-positive and Gram-negative bacteria.…”

Section: Nanoparticles For Antimicrobial Applications and Their Mecha...mentioning

confidence: 99%

“…The normal size of these gold NPs is 5−400 nm, and they can decrease the attachment of tRNA to ribosome units and cause bacterial death. 19 For instance, 4,6-diamino-2-pyrimidine thiol was used to surface-functionalize gold NPs, producing pyrimidine-capped gold NPs 119 which exhibited activity against resistant strains of Pseudomonas aeruginosa and E. coli. The mechanisms of action of these NPs were explored with gel electrophoresis that showed the NPs were binding to bacterial DNA, while images from electron microscope showed leakage of nucleic acids.…”

Section: Nanoparticles For Antimicrobial Applications and Their Mecha...mentioning

confidence: 99%

“…The physicochemical properties of NPs, such as shape, size, and surface chemistry and porosity are very unique, and these parameters impact their therapeutic activity . NPs generally vary in size from 10 to 1000 nm (vs 1 μm for bacteria), and the size can be engineered depending on the targeted bacteria and the mechanism of action. − Also, NP–bacteria cell interactions can be further modulated or regulated by functionalizing the NPs surface. − Therefore, nanotechnology can provide a novel toolkit to combat not only bacterial infections but also antimicrobial resistance.…”

Section: Introductionmentioning

confidence: 99%

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Nanomaterials: The New Antimicrobial Magic Bullet

et al. 2022

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Bacterial infections are a significant cause of mortality and morbidity worldwide, despite decades of use of numerous existing antibiotics and constant efforts by researchers to discover new antibiotics. The emergence of infections associated with antibiotic-resistant bacterial strains, has amplified the pressure to develop additional bactericidal therapies or new unorthodox approaches that can deal with antimicrobial resistance. Nanomaterial-based strategies, particularly those that do not rely on conventional small-molecule antibiotics, offer promise in part due to their ability to dodge existing mechanisms used by drugresistant bacteria. Therefore, the use of nanomaterial-based formulations has attracted attention in the field of antibiotic therapy. In this Review, we highlight novel and emerging nanomaterial-based formulations along with details about the mechanisms by which nanoparticles can target bacterial infections and antimicrobial resistance. A detailed discussion about types and the activities of nanoparticles is presented, along with how they can be used as either delivery systems or as inherent antimicrobials, or a combination of both. Lastly, we highlight some toxicological concerns for the use of nanoparticles in antibiotic therapies.

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“…These particles also allow targeted administration to specific organs or cells or controlled drug delivery. Recent developments in treatment have increased the demand for a new intelligent drug delivery design with more advanced power, efficiency, and properties to ensure the effectiveness of treatment with sufficient availability and ability of encapsulation ( Hosseini et al., 2022 ).…”

Section: Plgamentioning

confidence: 99%

PLGA-Based Nanoplatforms in Drug Delivery for Inhibition and Destruction of Microbial Biofilm

Shariati

Chegini

Ghaznavi‐Rad

et al. 2022

Front. Cell. Infect. Microbiol.

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The biofilm community of microorganisms has been identified as the dominant mode of microbial growth in nature and a common characteristic of different microorganisms such as Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis. The biofilm structure helps in the protection from environmental threats including host immune system and antimicrobial agents. Thus, the biofilm community has led to a higher prevalence of multidrug-resistant (MDR) strains in recent years. In this regard, the use of a new class of antibiotics, natural compounds, and anti-biofilm enzymes has been considered for the destruction of the microbial biofilm. However, different drawbacks such as low penetration, high susceptibility to degradation, instability, and poor solubility in aqueous solutions limit the use of anti-biofilm agents (ABAs) in a clinical setting. As such, recent studies have been using poly lactic-co-glycolic acid (PLGA)-based nanoplatforms (PLGA NPFs) for delivery of ABAs that have reported promising results. These particles, due to proper drug loading and release kinetics, could suppress microbial attachment, colonization, and biofilm formation for a long time. Additionally, PLGA NPFs, because of the high drug-loading efficiencies, hydrophilic surface, negative charge, and electrostatic interaction, lead to effective penetration of antibiotics to the deeper layer of the biofilm, thereby eliminating the microbial biofilm. Thus, PLGA NPFs could be considered as a potential candidate for coating catheters and other medical material surfaces for inhibition and destruction of the microbial biofilm. However, the exact interaction of PLGA NPFs and the microbial biofilm should be evaluated in animal studies. Additionally, a future goal will be to develop PLGA formulations as systems that can be used for the treatment of the MDR microbial biofilm, since the exact interactions of PLGA NPFs and these biofilm structures are not elucidated. In the present review article, we have discussed various aspects of PLGA usage for inhibition and destruction of the microbial biofilm along with different methods and procedures that have been used for improving PLGA NPF efficacy against the microbial biofilm.

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Nano drug delivery in intracellular bacterial infection treatments

Cited by 27 publications

References 135 publications

Codelivery of Doxycycline and Hydroxychloroquine to Treatment of Brucellosis: An Animal Study

Codelivery of Doxycycline and Hydroxychloroquine to Treatment of Brucellosis: An Animal Study

Nanomaterials: The New Antimicrobial Magic Bullet

PLGA-Based Nanoplatforms in Drug Delivery for Inhibition and Destruction of Microbial Biofilm

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