Abstract:Chemical probing experiments interrogate RNA structure by reacting with unpaired residues whose positions are typically read out by mutational profiling on short-read sequencing machines. Such experiments make rapid and genome-wide measurements of RNA structure, but short sequencing reads can rarely be mapped to specific transcript isoforms. Consequently, RNA structure information is acquired as a population average in common regions between transcripts. Here, we present nanopore dimethyl-sulfate mutational pr… Show more
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