Nano Defensin: A Promising Antibacterial Agent Against Colorectal Cancer Related Bacteria

Abdelraouf, Ahmed Mohamed Nabil; Naguib, Deyala M.

doi:10.1007/s10989-021-10237-5

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Naguib et al created nano defensins as antimicrobial agents. [116] Fenugreek seeds were used to extract and purify defensin, which was then immobilized on nano chitosan to create nano defensin. The MIC of nano defensins (10.6 μg mL −1 ) against F. nucleatum was found to be much lower than that of free defensins (66 μg mL −1 ) and nano-chitosan (339.4 μg mL −1 ).…”

Section: Oxapampa Propolis Flavonoidsmentioning

confidence: 99%

Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges

Liu,

Yu,

Dong

et al. 2023

Exploration

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Colorectal cancer (CRC) is generally characterized by a high prevalence of Fusobacterium nucleatum (F. nucleatum), a spindle‐shaped, Gram‐negative anaerobe pathogen derived from the oral cavity. This tumor‐resident microorganism has been closely correlated with the occurrence, progression, chemoresistance and immunosuppressive microenvironment of CRC. Furthermore, F. nucleatum can specifically colonize CRC tissues through adhesion on its surface, forming biofilms that are highly resistant to commonly used antibiotics. Accordingly, it is crucial to develop efficacious non‐antibiotic approaches to eradicate F. nucleatum and its biofilms for CRC treatment. In recent years, various antimicrobial strategies, such as natural extracts, inorganic chemicals, organic chemicals, polymers, inorganic‐organic hybrid materials, bacteriophages, probiotics, and vaccines, have been proposed to combat F. nucleatum and F. nucleatum biofilms. This review summarizes the latest advancements in anti‐F. nucleatum research, elucidates the antimicrobial mechanisms employed by these systems, and discusses the benefits and drawbacks of each antimicrobial technology. Additionally, this review also provides an outlook on the antimicrobial specificity, potential clinical implications, challenges, and future improvements of these antimicrobial strategies in the treatment of CRC.

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Section: Oxapampa Propolis Flavonoidsmentioning

confidence: 99%