Potential Role of Herbal- and Bacterial-Derived Peptides Against Colorectal Cancer

Abdoullahi, Shahroukh; Jahangiri, Abolfazl; Halabian, Raheleh

doi:10.1007/s43450-022-00276-4

Cited by 2 publications

(3 citation statements)

References 196 publications

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“…Ahwon et al found that licorice chalcone B could induce ROS-dependent apoptosis in oxaliplatin-resistant colorectal cancer cells via p38/JNK MAPK signaling [10]. In addition, several studies have shown that active compounds such as photoglycyrrhizidine [11], dihydroflavonoids from licorice [12], glycyrrhizic acid [13], and isoglycyrrhizin [14] can inhibit the proliferation, invasion, and migration of colorectal cancer cells and induce apoptosis. These findings suggest that the important role of licorice in anticolorectal cancer, especially licorice can reverse the resistance to chemotherapeutic drugs, is less in clinical studies and insufficiently articulated with basic research, which deserves our attention.…”

Section: Licoricementioning

confidence: 99%

Progress in the Study of the Effects and Mechanisms of Medicinal and Food Herbs and Their Active Ingredients on Colorectal Cancer

Li,

Yang,

Hao

et al. 2024

JCMP

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Colorectal cancer (CRC) is the fourth deadliest cancer in the world, with nearly 900,000 deaths annually. Although environmental and genetic factors as well as population aging are key in the pathogenesis of colorectal cancer, numerous studies have shown that dietary habits and nutrition may play both causal and protective roles in the development of colorectal cancer. "With the in-depth development and research of traditional Chinese medicine (TCM), the anticolorectal cancer effects of "medicinal food and herbs" have been gradually explored, and have received widespread attention due to their safe and significant therapeutic and healthcare effects. This paper summarizes and discusses the effects and mechanisms of "medicinal food" herbs and their active ingredients in colorectal cancer. This review is intended to serve as a reference for future research on anticolorectal cancer ingredients from "medicinal and food" herbal sources as drugs or food supplements.

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Section: Licoricementioning

confidence: 99%

Progress in the Study of the Effects and Mechanisms of Medicinal and Food Herbs and Their Active Ingredients on Colorectal Cancer

Li,

Yang,

Hao

et al. 2024

JCMP

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“…The AMP are highly abundant in higher plants especially Caryophyllaceae and Rhamnaceae families (Abdoullahi et al, 2022). Such peptides were reported to have potent antitumor activities which are cherimolacyclopeptide C, cycloheptapeptide, dianthins E, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Such peptides were reported to have potent antitumor activities which are cherimolacyclopeptide C, cycloheptapeptide, dianthins E, etc. The other type of AMPs is the antimicrobial proteins which consist of around 12 families of which three members are reported to have antitumor activities (Abdoullahi et al, 2022). Because of the antitumor activities of these proteins and peptides, they can be also named ACPs (anticancer proteins/peptides).…”

Section: Introductionmentioning

confidence: 99%

Prediction of anticancer peptides derived from the true lectins of Phoenix dactylifera and their synergetic effect with mitotane

Baothman,

Ali,

Hosawi

et al. 2024

Front. Pharmacol.

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Background and aims: Cancer continues to be a significant source of both illness and death on a global scale, traditional medicinal plants continue to serve as a fundamental resource of natural bioactive compounds as an alternative source of remedies. Although there have been numerous studies on the therapeutic role of Phoenix dactylifera, the study of the role of peptides has not been thoroughly investigated. This study aimed to investigate the anticancer activity of lectin peptides from P. dactylifera using in silico and in vivo analysis.Methods: Different computational tools were used to extract and predict anticancer peptides from the true lectins of P. dactylifera. Nine peptides that are bioactive substances have been investigated for their anticancer activity against MCF-7 and T47D (two forms of breast cancer). To counteract the unfavorable effects of mitotane, the most potent peptides (U3 and U7) were combined with it and assessed for anticancer activity against MCF-7 and HepG2.Results:In silico analysis revealed that nine peptides were predicted with anticancer activity. In cell lines, the lowest IC50 values were measured in U3 and U7 against MCF-7 and T47D cells. U3 or U7 in combination with mitotane demonstrated the lowest IC50 against MCF-7 and HepG2. The maximum level of cell proliferation inhibition was 22% when U3 (500 µg/mL) and 25 µg/mL mitotane were combined, compared to 41% when 25 µg/mL mitotane was used alone. When mitotane and U3 or U7 were combined, it was shown that these bioactive substances worked synergistically with mitotane to lessen its negative effects. The combination of peptides and mitotane could be regarded as an efficient chemotherapeutic medication having these bioactive properties for treating a variety of tumors while enhancing the reduction of side effects.

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Potential Role of Herbal- and Bacterial-Derived Peptides Against Colorectal Cancer

Cited by 2 publications

References 196 publications

Progress in the Study of the Effects and Mechanisms of Medicinal and Food Herbs and Their Active Ingredients on Colorectal Cancer

Progress in the Study of the Effects and Mechanisms of Medicinal and Food Herbs and Their Active Ingredients on Colorectal Cancer

Prediction of anticancer peptides derived from the true lectins of Phoenix dactylifera and their synergetic effect with mitotane

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