Nano-CdZr4(PO4)6 as a reusable and robust catalyst for the synthesis of bis-thiazolidinones by a multicomponent reaction of aldehydes, ethylenediamine and thioglycolic acid

Safaei‐Ghomi, Javad; Nazemzadeh, Seyed Hadi; Shahbazi‐Alavi, Hossein

doi:10.1080/17415993.2016.1267176

Cited by 17 publications

(9 citation statements)

References 22 publications

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“…Another nanoparticle catalyzed synthesis has been developed that uses CdZr 4 (PO 4 ) 6 as the catalyst, and bis-thiazolidinones have been synthesized in excellent yield ( Fig. 6) [17].…”

Section: -Thiazolidinonesmentioning

confidence: 99%

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Thiazolidinones: Synthesis, Reactivity, and Their Biological Applications

Nirwan

Chahal

Kakkar

2019

Journal of Heterocyclic Chem

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Thiazolidinone is a biologically important five‐membered heterocyclic ring having almost all types of biological activities. This review covers various types of thiazolidinones, such as 2‐thiazolidinones, 4‐thiazolidinones, 5‐thiazolidinones, 2‐thioxo‐4‐thiazolidinones, and thiazolidiene‐2,4‐dione. The literature related to the physical properties, chemical reactions, and synthesis for these derivatives has been included. Recent advances in the biological activities reported for 4‐thiazolidinone derivatives, such as peroxisome proliferator‐activated receptor γ binders, follicle‐stimulating hormone agonists, cystic fibrosis transmembrane conductance regulator inhibitors, and antioxidants, have been covered in this review. Thus, this study may help in further optimizing these thiazolidinone derivatives as more effective drug agents.

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“…Another nanoparticle catalyzed synthesis has been developed that uses CdZr 4 (PO 4 ) 6 as the catalyst, and bis-thiazolidinones have been synthesized in excellent yield ( Fig. 6) [17].…”

Section: -Thiazolidinonesmentioning

confidence: 99%

“…Further optimization in the ligand structure, by reversing the sulfonamide substitution at position R 1 , gave more potent inhibitors [15]. Other potent BRD4 inhibitors (16) and (17) were reported by two groups [55,56].…”

Section: Biological Significance Of 2-thiazolidinonesmentioning

confidence: 99%

Thiazolidinones: Synthesis, Reactivity, and Their Biological Applications

Nirwan

Chahal

Kakkar

2019

Journal of Heterocyclic Chem

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“…Safaei-Ghomi and his group [77] developed a novel, efficient, pseudo-five-component preparation of bis-thiazolidinones 31(a-j) from substituted benzaldehyde, ethylenediamine and TGA (3) with nano-CdZr 4 (PO 4 ) 6 as a retrievable and robust catalyst (Scheme 15). The 0.6 mol% catalyst loading was sufficient for the good yield of products.…”

Section: Scheme 12 Synthesis Of Compounds 26 and 27 Under Basic Condimentioning

confidence: 99%

“…Modified from Ref. [77] a sulfur atom of mercaptoacetic acid attacked the carbon atom of imine which was catalyzed by CoFe 2 O 4 @SiO 2 /PrNH 2 NPs followed by intramolecular cyclization to give thiazolidinones (Pathway A). In the second mechanism, initially, formation of amide took place from aldehyde, thioglycolic acid and amine followed by cyclocondensation of a carbonyl group of aldehyde with sulfur and a nitrogen motif catalyzed by the same NPs to give cyclic compounds, thiazolidinones (Pathway B) (Scheme 18).…”

Section: Scheme 16mentioning

confidence: 99%

“…But there is no detailed review of the synthesis and biological activity of 4 Comparative study of various synthetic protocols [58][59][60][61][62][63][64][65][66][67][68][69] Fig. 5 Comparative study of various synthetic protocols [77][78][79][80][81][82][83][84][85][86] Topics in Current Chemistry (2020) 378:34 1 3 34 Page 8 of 90 hoping to inspire new and even more creative approaches for researchers ( Fig. 3).…”

Section: Introductionmentioning

confidence: 99%

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Saturated Five-Membered Thiazolidines and Their Derivatives: From Synthesis to Biological Applications

Sahiba¹,

Sethiya²,

Soni³

et al. 2020

Top Curr Chem (Z)

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In past decades, interdisciplinary research has been of great interest for scholars. Thiazolidine motifs behave as a bridge between organic synthesis and medicinal chemistry and compel researchers to explore new drug candidates. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. The presence of sulfur enhances their pharmacological properties, and, therefore, they are used as vehicles in the synthesis of valuable organic combinations. They show varied biological properties viz. anticancer, anticonvulsant, antimicrobial, anti-inflammatory, neuroprotective, antioxidant activity and so on. This diversity in the biological response makes it a highly prized moiety. Based on literature studies, various synthetic approaches like multicomponent reaction, click reaction, nano-catalysis and green chemistry have been employed to improve their selectivity, purity, product yield and pharmacokinetic activity. In this review article, we have summarized systematic approaches for the synthesis of thiazolidine and its derivatives, along with their pharmacological activity, including advantages of green synthesis, atom economy, cleaner reaction profile and catalyst recovery which will help scientists to probe and stimulate the study of these scaffolds.

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Ultrasound‐Assisted Facile Synthesis and Antimicrobial Studies of Alkanediyl‐bis‐thiazolidin‐4‐ones and Alkanediyl‐bis‐thiazinan‐4‐ones

Kaur

Kaur²,

Gautam

et al. 2019

Journal of Heterocyclic Chem

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Alkanediyl‐bis‐2‐aryl‐thiazolidin‐4‐one and alkanediyl‐bis‐2‐aryl‐1,3‐thiazinan‐4‐one derivatives have been congregated in a single step reaction of diaminoalkanes, aryl aldehydes, and sulfanyl acids in the presence of coupling agent N,N′‐dicyclohexylcarbodiimide under ultrasonic conditions. This method of constructing 4‐keto derivatives of thiazolidine and thiazinane is quick and clean besides yielding the products in quantitative yields. The spectral techniques corroborated the structures of the isolated products. Biological assay of the synthesized products has also been reported.

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Nano-CdZr₄(PO₄)₆ as a reusable and robust catalyst for the synthesis of bis-thiazolidinones by a multicomponent reaction of aldehydes, ethylenediamine and thioglycolic acid

Cited by 17 publications

References 22 publications

Thiazolidinones: Synthesis, Reactivity, and Their Biological Applications

Thiazolidinones: Synthesis, Reactivity, and Their Biological Applications

Saturated Five-Membered Thiazolidines and Their Derivatives: From Synthesis to Biological Applications

Ultrasound‐Assisted Facile Synthesis and Antimicrobial Studies of Alkanediyl‐bis‐thiazolidin‐4‐ones and Alkanediyl‐bis‐thiazinan‐4‐ones

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