Nano-bio control of bacteria: A novel mechanism for antibacterial activities of magnetic nanoparticles as a temporary nanomagnets

Boroon, Sadjad; Kakanejadifard, Ali; Motamedi, Hossein

doi:10.1016/j.molliq.2017.12.036

Cited by 5 publications

(4 citation statements)

References 48 publications

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Section: Magnetic Stimulation‐based Npasmentioning

confidence: 99%

“…In addition, modified MNPs exhibit bacterial recognition and capture efficiency and can be easily controlled and recycled by an external magnetic field, which can be fully exploited to achieve enhanced antimicrobial performance. [86] MNPs can convert magnetic energy to heat through Neel relaxation and Brownian relaxation under the stimulation of alternating magnetic fields, thus offering a novel magnetic sterilization mechanism via the magnetothermal effect of MNPs. The heat generated by MNPs depends on the particle size and relaxation time.…”

Section: Magnetic Stimulation-based Npasmentioning

confidence: 99%

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Nanophysical Antimicrobial Strategies: A Rational Deployment of Nanomaterials and Physical Stimulations in Combating Bacterial Infections

Jia

Wang

et al. 2022

Advanced Science

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The emergence of bacterial resistance due to the evolution of microbes under antibiotic selection pressure, and their ability to form biofilm, has necessitated the development of alternative antimicrobial therapeutics. Physical stimulation, as a powerful antimicrobial method to disrupt microbial structure, has been widely used in food and industrial sterilization. With advances in nanotechnology, nanophysical antimicrobial strategies (NPAS) have provided unprecedented opportunities to treat antibiotic-resistant infections, via a combination of nanomaterials and physical stimulations. In this review, NPAS are categorized according to the modes of their physical stimulation, which include mechanical, optical, magnetic, acoustic, and electrical signals. The biomedical applications of NPAS in combating bacterial infections are systematically introduced, with a focus on their design and antimicrobial mechanisms. Current challenges and further perspectives of NPAS in the clinical treatment of bacterial infections are also summarized and discussed to highlight their potential use in clinical settings. The authors hope that this review will attract more researchers to further advance the promising field of NPAS, and provide new insights for designing powerful strategies to combat bacterial resistance.

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Section: Magnetic Stimulation‐based Npasmentioning

confidence: 99%

Section: Magnetic Stimulation-based Npasmentioning

confidence: 99%

Nanophysical Antimicrobial Strategies: A Rational Deployment of Nanomaterials and Physical Stimulations in Combating Bacterial Infections

Jia

Wang

et al. 2022

Advanced Science

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Section: Introductionmentioning

confidence: 99%

“…Furthermore, through controllable triggers responsive to the bacterium-infected microenvironment, a nano drug delivery system can achieve enhanced local bactericidal concentration and eliminate premature release of the loaded drug. , Our previous studies have shown that Ru NPs with different morphologies can deliver anticancer drugs to tumor cells and protect drugs from protein adsorption in the body during transport. , In addition, we have previously reported that Ru NPs had a good photothermal effect and can be used for antibacterial photothermal therapy . As is known, photothermal therapy is an effective antibacterial strategy without involving drug resistance. − Additionally, among the various kinds of nanoparticle-based delivery systems, mesoporous nanomaterials are one of the most promising nanocarriers. , Thus, Ru NPs with a mesoporous structure are designed and synthesized, combining their photothermal properties with a large pore volume.…”

Section: Introductionmentioning

confidence: 99%

Enzyme-Responsive Mesoporous Ruthenium for Combined Chemo-Photothermal Therapy of Drug-Resistant Bacteria

Liu

Lin

Liu

et al. 2019

ACS Appl. Mater. Interfaces

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The rapid mutation of drug-resistant bacteria and the serious lag of development of new antibiotics necessitate research on novel antibacterial agents. Nanomaterials with unique size effect and antibacterial mechanism could serve as an alternative for antibiotics, since they showed low possibility to develop drug-resistant bacteria. Here, an enzyme-responsive nanosystem, AA@Ru@HA-MoS 2 , with a synergistic chemo-photothermal therapy function is proposed to treat bacterial infections. Mesoporous ruthenium nanoparticles (Ru NPs) were used as nanocarriers, loading prodrug ascorbic acid (AA) and encapsulated by hyaluronic acid (HA). Then, molybdenum disulfide (MoS 2 ) precoated with ciprofloxacin was used as a catalyst with targeting effect binding to the outer surface. When the nanosystem gathered at the infection site, Hyal secreted by bacteria could degrade the HA capping and trigger the release of AA and then generated hydroxyl radicals ( • OH) in situ by the catalysis of MoS 2 . In addition, taking advantage of the good photothermal property of Ru NPs, combined chemo-photothermal antibacterial therapy could be achieved. The nanosystem exhibited potent bactericidal activity against drug-resistant Gram-positive and Gram-negative bacteria. Furthermore, it could break down the biofilm, inhibit the contained bacteria, and prevent the formation of a new biofilm. The in vivo bacterium-infected model also proved accelerated wound healing. The study showed a high potential of AA@Ru@ HA-MoS 2 as a novel enzyme-responsive nanosystem for combating drug-resistant bacterial infection.

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Nanoantimicrobials Mechanism of Action

Mostafa

Asran-Amal

Almoammar

et al. 2018

Nanotechnology in the Life Sciences

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Nano-bio control of bacteria: A novel mechanism for antibacterial activities of magnetic nanoparticles as a temporary nanomagnets

Cited by 5 publications

References 48 publications

Nanophysical Antimicrobial Strategies: A Rational Deployment of Nanomaterials and Physical Stimulations in Combating Bacterial Infections

Nanophysical Antimicrobial Strategies: A Rational Deployment of Nanomaterials and Physical Stimulations in Combating Bacterial Infections

Enzyme-Responsive Mesoporous Ruthenium for Combined Chemo-Photothermal Therapy of Drug-Resistant Bacteria

Nanoantimicrobials Mechanism of Action

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