Nano- and micro-materials in the treatment of internal bleeding and uncontrolled hemorrhage

Gaston, E. Thayer; Fraser, John F.; Xu, Zhi Ping; Ta, Hang T.

doi:10.1016/j.nano.2017.11.007

Cited by 40 publications

(31 citation statements)

References 83 publications

(121 reference statements)

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“…Also, particles exhibited response to pH, presenting them as promising candidate for magnetic drug delivery. Iron oxide nanoparticles as negative contrast agents for magnetic resonance imaging (MRI) have been employed widely for detection of diseases (Ta et al, 2011, 2017a,b, 2018; Gaston et al, 2018; Wu et al, 2018; Yusof et al, 2019; Zhang et al, 2019). Multifunctional PASP nanoparticles containing iron oxide nanocrystals and doxorubicin was also developed for simultaneous diagnosis and treatment of cancer by Yang et al (2011).…”

Section: Pasp Hydrogel Applicationsmentioning

confidence: 99%

Hydrogels Based on Poly(aspartic acid): Synthesis and Applications

et al. 2019

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This review presents an overview on the recent progress in the synthesis, crosslinking, interpenetrating networks, and applications of poly(aspartic acid) (PASP)-based hydrogels. PASP is a synthetic acidic polypeptide that has drawn a great deal of attention in diverse applications due particularly to its biocompatibility and biodegradability. Facile modification of its precursor, poly(succinimide) (PSI), by primary amines has opened a wide window for the design of state-of-the-art hydrogels. Apart from pH-sensitivity, PASP hydrogels can be modified with suitable species in order to respond to the other desired stimuli such as temperature and reducing/oxidizing media as well. Strategies for fabrication of nanostructured PASP-based hydrogels in the form of particle and fiber are also discussed. Different cross-linking agents for PSI/PASP such as diamines, dopamine, cysteamine, and aminosilanes are also introduced. Finally, applications of PASP-based hydrogels in diverse areas particularly in biomedical are reviewed.

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Section: Pasp Hydrogel Applicationsmentioning

confidence: 99%

Hydrogels Based on Poly(aspartic acid): Synthesis and Applications

et al. 2019

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“…Finally, nanotechnology has been applied for hemostasis [222]. Some novel hemostatic agents based on nanomaterials are intriguing [223]; however, it may be some time before they are brought to clinical trials. For example, nano-and micromaterials have been developed for the treatment of internal bleeding and uncontrolled hemorrhage [223]; however, these novel hemostatic agents again may prove to be efficacious (or not) with further studies.…”

Section: Future Directionsmentioning

confidence: 99%

“…Some novel hemostatic agents based on nanomaterials are intriguing [223]; however, it may be some time before they are brought to clinical trials. For example, nano-and micromaterials have been developed for the treatment of internal bleeding and uncontrolled hemorrhage [223]; however, these novel hemostatic agents again may prove to be efficacious (or not) with further studies. There are also new delivery systems (e.g., self-driven and trauma-targeted delivery) that would make current hemostatic agents more effective [224,225].…”

Section: Future Directionsmentioning

confidence: 99%

Hemostatic agents for prehospital hemorrhage control: a narrative review

Peng

2020

Military Med Res

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Hemorrhage is the leading cause of preventable death in combat trauma and the secondary cause of death in civilian trauma. A significant number of deaths due to hemorrhage occur before and in the first hour after hospital arrival. A literature search was performed through PubMed, Scopus, and Institute of Scientific Information databases for English language articles using terms relating to hemostatic agents, prehospital, battlefield or combat dressings, and prehospital hemostatic resuscitation, followed by cross-reference searching. Abstracts were screened to determine relevance and whether appropriate further review of the original articles was warranted. Based on these findings, this paper provides a review of a variety of hemostatic agents ranging from clinically approved products for human use to newly developed concepts with great potential for use in prehospital settings. These hemostatic agents can be administered either systemically or locally to stop bleeding through different mechanisms of action. Comparisons of current hemostatic products and further directions for prehospital hemorrhage control are also discussed.

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“…developed a cross‐linked dextran‐coated iron oxide (CLIO) nanoparticles for the macrophages ablation in atherosclerosis. Iron oxide‐based nanoparticles have been developed widely for molecular imaging of CVDs . The CLIO nanoparticles in McCarthy study were coated with dextran to specifically target to macrophages and labelled with the near‐infrared (NIR) fluorescent dye, Alexa Fluor 750 (AF750) and a chlorin‐based photosensitiser, 5‐(4‐car‐boxyphenyl)‐10,15,20‐triphenyl‐2,3‐dihydroxychlorin (TPC), which make CLIO can be detected by MRI and fluorescence imaging (Figure a).…”

Section: Theranostic Nanomedicine For Atherosclerosismentioning

confidence: 99%

Treatment of atherosclerotic plaque: perspectives on theranostics

Zhang

Koradia

Kamato

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives Atherosclerosis, a progressive condition characterised by the build-up of plaque due to the accumulation of low-density lipoprotein and fibrous substances in the damaged arteries, is the major underlying pathology of most cardiovascular diseases. Despite the evidence of the efficacy of the present treatments for atherosclerosis, the complex and poorly understood underlying mechanisms of atherosclerosis development and progression have prevented them from reaching their full potential. Novel alternative treatments like usage of nanomedicines and theranostics are gaining attention of the researchers worldwide. This review will briefly discuss the current medications for the disease and explore potential future developments based on theranostics nanomaterials that may help resolve atherosclerotic cardiovascular disease. Key findings Various drugs can slow the effects of atherosclerosis. They include hyperlipidaemia medications, anti-platelet drugs, hypertension and hyperglycaemia medications. Most of the theranostic agents developed for atherosclerosis have shown the feasibility of rapid and noninvasive diagnosis, as well as effective and specific treatment in animal models. However, there are still some limitation exist in their structure design, stability, targeting efficacy, toxicity and production, which should be optimized in order to develop clinically acceptable nanoparticle based theronostics for atherosclerosis. Summary Current medications for atherosclerosis and potential theranostic nanomaterials developed for the disease are discussed in the current review. Further investigations remain to be carried out to achieve clinical translation of theranostic agents for atherosclerosis.

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Nano- and micro-materials in the treatment of internal bleeding and uncontrolled hemorrhage

Cited by 40 publications

References 83 publications

Hydrogels Based on Poly(aspartic acid): Synthesis and Applications

Hydrogels Based on Poly(aspartic acid): Synthesis and Applications

Hemostatic agents for prehospital hemorrhage control: a narrative review

Treatment of atherosclerotic plaque: perspectives on theranostics

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