Hydrogels Based on Poly(aspartic acid): Synthesis and Applications

Adelnia, Hossein; Blakey, Idriss; Little, Peter J.; Ta, Hang T.

doi:10.3389/fchem.2019.00755

Cited by 45 publications

(40 citation statements)

References 101 publications

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“…These limitations were overcome by the development of synthetic hydrogels, which provide flexibility in terms of chemical modification, varying degrees of porosity and stiffness, improved stability, biocompatibility, degradability, and the tuning of the mechanical strength for different cellular applications. Commonly used synthetic hydrogels in microfluidics are poly-ethylene glycol, poly-vinyl alcohol, polyacrylamide, poly-aspartic acid, and poly-2-hydroxy ethyl methacrylate [ 138 , 139 ]. These hydrogel-based 3D microfluidic cell culture devices can be used to investigate cell proliferation, metastasis, cell-to-cell contact as well as in vitro drug screening in oncology research.…”

Section: Hydrogel-based Microfluidic Models In Oncology Researchmentioning

confidence: 99%

Advances in Hydrogel-Based Microfluidic Blood–Brain-Barrier Models in Oncology Research

et al. 2022

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The intrinsic architecture and complexity of the brain restricts the capacity of therapeutic molecules to reach their potential targets, thereby limiting therapeutic possibilities concerning neurological ailments and brain malignancy. As conventional models fail to recapitulate the complexity of the brain, progress in the field of microfluidics has facilitated the development of advanced in vitro platforms that could imitate the in vivo microenvironments and pathological features of the blood–brain barrier (BBB). It is highly desirous that developed in vitro BBB-on-chip models serve as a platform to investigate cancer metastasis of the brain along with the possibility of efficiently screening chemotherapeutic agents against brain malignancies. In order to improve the proficiency of BBB-on-chip models, hydrogels have been widely explored due to their unique physical and chemical properties, which mimic the three-dimensional (3D) micro architecture of tissues. Hydrogel-based BBB-on-chip models serves as a stage which is conducive for cell growth and allows the exchange of gases and nutrients and the removal of metabolic wastes between cells and the cell/extra cellular matrix (ECM) interface. Here, we present recent advancements in BBB-on-chip models targeting brain malignancies and examine the utility of hydrogel-based BBB models that could further strengthen the future application of microfluidic devices in oncology research.

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Section: Hydrogel-based Microfluidic Models In Oncology Researchmentioning

confidence: 99%

Advances in Hydrogel-Based Microfluidic Blood–Brain-Barrier Models in Oncology Research

et al. 2022

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“…Further, poly(aspartic acid)-based hydrogels are flexible to modification under mild conditions without any catalyst requirement. This feature makes poly(aspartic acid)based hydrogels promising over conventional poly(acrylic acid) hydrogels [32].…”

Section: Poly(aspartic Acid)mentioning

confidence: 99%

Polyamide/Poly(Amino Acid) Polymers for Drug Delivery

Boddu

Bhagav

Karla

et al. 2021

JFB

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Polymers have always played a critical role in the development of novel drug delivery systems by providing the sustained, controlled and targeted release of both hydrophobic and hydrophilic drugs. Among the different polymers, polyamides or poly(amino acid)s exhibit distinct features such as good biocompatibility, slow degradability and flexible physicochemical modification. The degradation rates of poly(amino acid)s are influenced by the hydrophilicity of the amino acids that make up the polymer. Poly(amino acid)s are extensively used in the formulation of chemotherapeutics to achieve selective delivery for an appropriate duration of time in order to lessen the drug-related side effects and increase the anti-tumor efficacy. This review highlights various poly(amino acid) polymers used in drug delivery along with new developments in their utility. A thorough discussion on anticancer agents incorporated into poly(amino acid) micellar systems that are under clinical evaluation is included.

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“…Among the potential high-value applications for extracted lignin, it has, for instance, been proposed as a natural, biodegradable antioxidant; 9 , 10 however, its chemistry heavily dictates its radical scavenging activity. 9 , 11 Other petroleum replacing applications, heavily depending on lignin chemistry, include utilization in hydrophobic composites, 12 , 13 for lubricant production, 14 , 15 carbon fiber production, 16 , 17 nanoparticles, 18 adsorption purposes in aqueous remediation systems, 19 , 20 or production of low-molecular-weight aromatics and hydrocarbons. 21 , 22 Despite the fact that lignin chemistry will heavily influence its suitability for a specific application, there is nowadays still a lot of need for strictly connecting isolation process parameters to chemical features of the extracted lignin and the abundance of specific structural motifs and the resulting consequences for suitable high-value applications.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Organosolv Birch Lignins: Toward Application-Specific Lignin Production

et al. 2021

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Organosolv pretreatment represents one of the most promising biomass valorization strategies for renewable carbon-based products; meanwhile, there is an overall lack of holistic approach to how extraction conditions affect the suitable end-usages. In this context, lignin extracted from silver birch ( Betula pendula L.) by a novel hybrid organosolv/steam-explosion treatment at varying process conditions (EtOH %; time; catalyst %) was analyzed by quantitative NMR ( 1 H– 13 C HSQC; 13 C NMR; 31 P NMR), gel permeation chromatography, Fourier transform infrared (FT-IR), Pyr-gas chromatography–mass spectroscopy (GC/MS), and thermogravimetric analysis, and the physicochemical characteristics of the lignins were discussed regarding their potential usages. Characteristic lignin interunit bonding motifs, such as β- O -4′, β-β′, and β-5′, were found to dominate in the extracted lignins, with their abundance varying with treatment conditions. Low-molecular-weight lignins with fairly unaltered characteristics were generated via extraction with the highest ethanol content potentially suitable for subsequent production of free phenolics. Furthermore, β-β′ and β-5′ structures were predominant at higher acid catalyst contents and prolonged treatment times. Higher acid catalyst content led to oxidation and ethoxylation of side-chains, with the concomitant gradual disappearance of p -hydroxycinnamyl alcohol and cinnamaldehyde. This said, the increasing application of acid generated a broad set of lignin characteristics with potential applications such as antioxidants, carbon fiber, nanoparticles, and water remediation purposes.

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Hydrogels Based on Poly(aspartic acid): Synthesis and Applications

Cited by 45 publications

References 101 publications

Advances in Hydrogel-Based Microfluidic Blood–Brain-Barrier Models in Oncology Research

Advances in Hydrogel-Based Microfluidic Blood–Brain-Barrier Models in Oncology Research

Polyamide/Poly(Amino Acid) Polymers for Drug Delivery

Characterization of Organosolv Birch Lignins: Toward Application-Specific Lignin Production

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