Nano-amino acid cellulose derivatives: Eco-synthesis, characterization, and antimicrobial properties

Hasanin, Mohamed S.; Elhenawy, Ahmed A.; Eisa, Wael H.; El‐Saied, Houssni; Sameeh, Manal Y.

doi:10.1016/j.ijbiomac.2019.04.024

Cited by 46 publications

(9 citation statements)

References 31 publications

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“…Biopolymers are polymeric materials produced by living organisms [21], which include polysaccharides, and are characterized by their bioavailability [22], biodegradability, and sustainability [23]. In this regard, cellulose and its derivatives are excellent examples of biopolymers, as cellulose is the most abundant biopolymer on earth [24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Development of Antimicrobial Laser-Induced Photodynamic Therapy Based on Ethylcellulose/Chitosan Nanocomposite with 5,10,15,20-Tetrakis(m-Hydroxyphenyl)porphyrin

et al. 2021

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The development of new antimicrobial strategies that act more efficiently than traditional antibiotics is becoming a necessity to combat multidrug-resistant pathogens. Here we report the efficacy of laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans. Surface loading of the ethylcelllose/chitosan composite with mTHPP was carried out and the resulting nanocomposite was fully characterized. The results indicate that the prepared nanocomposite incorporates mTHPP inside, and that the composite acquired an overall positive charge. The incorporation of mTHPP into the nanocomposite enhanced the photo- and thermal stability. Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5–70 mW), and exposure times (15–45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min. Utilization of higher doses (70 mW) for longer periods achieved more eradication of microbial growth.

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Section: Introductionmentioning

confidence: 99%

Development of Antimicrobial Laser-Induced Photodynamic Therapy Based on Ethylcellulose/Chitosan Nanocomposite with 5,10,15,20-Tetrakis(m-Hydroxyphenyl)porphyrin

et al. 2021

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“…The infectious diseases caused by bacterial contamination pose a serious threat to human health in many sectors including environmental, packaging, food, textile as well as hospital and medical care. To stop the spreading of the diseases, the development of antibacterial agents derived from metal oxides and cellulose-based nanomaterials has attained a growing interest in recent years [1][2][3][4]. Metal oxides nanomaterials with antibacterial properties when encapsulated or coated onto surfaces can meet extensive applications in water treatment, packaging, coating, wound healing, and the biomedical field [1,5].…”

Section: Introductionmentioning

confidence: 99%

Optimized Synthesis of Biopolymer-Based Zinc Oxide Nanoparticles and Evaluation of Their Antibacterial Activity

et al. 2021

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Owing to their unique properties, zinc oxide nanoparticles (ZnO NPs) have a broad range of exciting applications. However, the problem of nanoparticles aggregation remains challenging. So, biopolymers of polysaccharides can provide green and promising stabilizers as alternatives to the current toxic chemical stabilizers during ZnO NPs synthesis. The main idea in this investigation is to tune ZnO NPs with an appropriate texture, shape, and size for antibacterial application. So, this work compares the use of three different eco-friendly stabilizers namely starch, carboxymethyl cellulose, and hydroxyethyl cellulose as alternatives capping agents in the fabrication of ZnO NPs at various times. The optimized ZnO NPs sample was obtained using starch as the optimum stabilizer at reaction conditions of 0.5 h, room temperature (25 °C), 1:2 )MZn:MNaOH) ratio and 1% (w/v) starch concentration. The optical, texture, and structural properties of prepared ZnO NPs were characterized by UV-Vis, DLS, zeta potential, FT-IR, and TEM techniques. ZnO NPs showed a mean zeta potential of −21.6 mV, explaining that they are moderately stable. The analysis by TEM confirmed that the NPs were spherical and have an average size of 23 nm. The antibacterial properties of ZnO NPs against Gram-positive (Bacillus subtilis and Staphylococcus epidermidis) and Gramnegative (Enterobacter cloacae and Escherichia coli) bacteria were evaluated based on the zone of inhibition (ZOI) values expressed in mm. The results showed promising performances for their antibacterial activity against the tested bacteria which indicated a strong antibacterial activity of ZnO NPs against B. subtilis, S. epidermidis, and E. cloacae with ZOI values of 17, 14 and 16 mm, respectively, and it showed moderate activity against E. coli (ZOI = 10 mm). The synthesis of biopolymer stabilized ZnO NPs by this approach could be eco-friendly and cost-effective and synthesized ZnO NPs can serve as promising antibacterial agents.

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“…Characteristic peaks were observed for glycogen at 3397, 2915, 1640, 155, and 1038 cm −1 , indicating O-H stretching, C-O stretching, the over tone of the hydroxyl group, and stretching of the Carbon/Oxygen single bond and CH2-O-CH2, respectively [24]. Additionally, the pure gelatin showed characteristic peaks at 3291, 2931, 1719, 1259 and 1041 cm −1 , which were attributed to overlapping of NH and OH bond stretching vibration, carboxylic group stretching vibrations, C=O stretching, NH bending vibration of the amide group and C-O-C of the amide bond in gelatin stretching vibrations, respectively [25]. In context, the pure Griseofulvin was recorded a clear peaks characteristic the Griseofulvin at 3436, 2944, 1712, 1615 and 1584 cm −1 indicating adsorbed water vapor from the environment, vibrations in CH2 groups, the C=O stretch of the benzofuranone ring, cyclohexanone carbonyl hydrogen bonds and C=C stretch of the cyclic ring, respectively [26][27][28].…”

Section: Ft-irmentioning

confidence: 97%

Enhancing the Antifungal Activity of Griseofulvin by Incorporation a Green Biopolymer-Based Nanocomposite

et al. 2021

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Fungal biofilms have caused several medical problems, resulting in significant morbidity and mortality as well as poor response to antifungal drugs. The current study was designed to evaluate the enhancement of antifungal and anti-biofilm activity of Griseofulvin-loaded green nanocomposite-based biopolymers (Ge-Nco) of glycogen and gelatin against different strains of pathogenic Candida species. The prepared Ge-Nco was characterized using Fourier-transform infrared (FT-IR), X-ray diffraction pattern (XRD), scanning electron microscopy-energy dispersive X-ray (SEM-EDX) and transmission electron microscope (TEM). In addition, the morphology of the mature biofilm and the inhibition of biofilm was monitored and visualized using confocal laser scanning microscopy (CLSM). The minimal inhibitory concentrations (MIC) and (IC50) of Griseofulvin alone and the prepared Ge-Nco against three different strains of Candida sp. were determined according to Clinical and Laboratory Standards Institute (CLSI) method. The effects of Griseofulvin alone and Ge-Nco on the tested Candida sp. biofilm formation were determined by the crystal-violet staining protocol. The biofilm inhibition potential of Ge-Nco against the tested Candida sp. was detected and depicted under CLSM (2.5 D view). The findings depicted that Ge-Nco was prepared in nanometer size (10–23 nm). The observed minimum inhibitory concentration (MIC) of Griseofulvin alone and Ge-Nco against three different Candida sp. were found to be in range 49.9–99.8 μg/mL and 6.24–12.48 μg/mL, respectively. These results provide evidence for implementing efficient antivirulence approaches against three different Candida sp. that would be less likely to foster the emergence of resistance.

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Nano-amino acid cellulose derivatives: Eco-synthesis, characterization, and antimicrobial properties

Cited by 46 publications

References 31 publications

Development of Antimicrobial Laser-Induced Photodynamic Therapy Based on Ethylcellulose/Chitosan Nanocomposite with 5,10,15,20-Tetrakis(m-Hydroxyphenyl)porphyrin

Development of Antimicrobial Laser-Induced Photodynamic Therapy Based on Ethylcellulose/Chitosan Nanocomposite with 5,10,15,20-Tetrakis(m-Hydroxyphenyl)porphyrin

Optimized Synthesis of Biopolymer-Based Zinc Oxide Nanoparticles and Evaluation of Their Antibacterial Activity

Enhancing the Antifungal Activity of Griseofulvin by Incorporation a Green Biopolymer-Based Nanocomposite

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