Nandrolone decanoate induces cardiac and renal remodeling in female rats, without modification in physiological parameters: The role of ANP system

Brasil, Girlândia Alexandre; Lima, Ewelyne Miranda de; Nascimento, Andrews Marques do; Caliman, Izabela Facco; Medeiros, Ana Raquel Santos; Silva, Mauro S.B.; Abreu, Gláucia Rodrigues de; Reis, Adelina Martha dos; Andrade, Tadeu Uggere de; Bissoli, Nazaré Souza

doi:10.1016/j.lfs.2015.07.005

Cited by 20 publications

(14 citation statements)

References 55 publications

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“…A recent report suggested that ND exposure promotes hypertrophy in proximal and distal convoluted tubules of mice kidneys [ 120 ]. Moreover, both testosterone activity and ND direct action to AR may play a role in the genesis of kidney fibrosis after long-term ND exposure [ 121 ].…”

Section: Discussionmentioning

confidence: 99%

Nandrolone Decanoate: Use, Abuse and Side Effects

et al. 2020

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Background and Objectives: Androgens play a significant role in the development of male reproductive organs. The clinical use of synthetic testosterone derivatives, such as nandrolone, is focused on maximizing the anabolic effects and minimizing the androgenic ones. Class II anabolic androgenic steroids (AAS), including nandrolone, are rapidly becoming a widespread group of drugs used both clinically and illicitly. The illicit use of AAS is diffused among adolescent and bodybuilders because of their anabolic proprieties and their capacity to increase tolerance to exercise. This systematic review aims to focus on side effects related to illicit AAS abuse, evaluating the scientific literature in order to underline the most frequent side effects on AAS abusers’ bodies. Materials and Methods: A systematic review of the scientific literature was performed using the PubMed database and the keywords “nandrolone decanoate”. The inclusion criteria for articles or abstracts were English language and the presence of the following words: “abuse” or “adverse effects”. After applying the exclusion and inclusion criteria, from a total of 766 articles, only 148 were considered eligible for the study. Results: The most reported adverse effects (found in more than 5% of the studies) were endocrine effects (18 studies, 42%), such as virilization, gynecomastia, hormonal disorders, dyslipidemia, genital alterations, and infertility; cardiovascular dysfunctions (six studies, 14%) such as vascular damage, coagulation disorders, and arteriosus hypertension; skin disorders (five studies, 12%) such as pricking, acne, and skin spots; psychiatric and mood disorders (four studies, 9%) such as aggressiveness, sleep disorders and anxiety; musculoskeletal disorders (two studies, 5%), excretory disorders (two studies, 5%), and gastrointestinal disorders (two studies, 5%). Conclusions: Based on the result of our study, the most common adverse effects secondary to the abuse of nandrolone decanoate (ND) involve the endocrine, cardiovascular, skin, and psychiatric systems. These data could prove useful to healthcare professionals in both sports and clinical settings.

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Section: Discussionmentioning

confidence: 99%

Nandrolone Decanoate: Use, Abuse and Side Effects

et al. 2020

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“…It is well known that ND can promote concentric cardiac hypertrophy associated with cardiac remodeling (Andrade et al, 2011;Brasil et al, 2015;Franquni et al, 2013) and that cardiovascular effects are combined with an imbalance among pro-and anti-inflammatory cytokine concentrations (Franquni et al, 2013). However, this is the first time that the worsening of these parameters has been demonstrated after enzymatic inhibition, suggesting that ND, not its metabolite DHN, is the most important molecule involved in these results.…”

Section: Discussionmentioning

confidence: 89%

“…Based on these results, we can infer that, in cardiac tissue, inhibition of 5αR promotes an increase in ND bioavailability and a decrease in DHT, which can explain the finding that the greatest hypertrophy occurred in the DECAF group. The hypertrophy observed in the heart is not limited to that tissue (Brasil et al, 2015).…”

Section: Discussionmentioning

confidence: 91%

Finasteride promotes worsening of the cardiac deleterious effects of nandrolone decanoate and protects against genotoxic and cytotoxic damage

Mata

Nascimento

Lima

et al. 2020

Braz. J. Pharm. Sci.

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Metabolism of anabolic androgenic steroids is important for its physiological effects. The aim was to investigate the effects of finasteride (a 5α-reductase inhibitor-5αR) on cardiac and mutagenic effects promoted by ND. Male Wistar rats were separated into three groups: CONT, received the vehicles of ND and finasteride (Peanut oil+Saline); DECA group, received ND (20 mg.kg.week-1 , i.m.), and DECAF received ND and finasteride (100 μg.kg-1 , i.p.), for four weeks. After, hypertrophy, cytokines and Angiotensin Converting Enzyme (ACE) activity was determined in heart. Bone marrow was used for micronucleus evaluation. Treatment with ND promotes increase in cardiac hypertrophy, ACE activity and disbalance among pro-and anti-inflammatory cytokines, and combination with finasteride worsened those effects. Association with finasteride ameliorates the toxic effects of ND on bone marrow cells, as was observed by a normalization of the number of micronucleate polychromatic erythrocytes and the mitotic index. Our data demonstrates that deleterious effects promoted by ND are depend, at least in part, of its metabolization. Also, inhibition of 5αR by finasteride present variated effects dependent on organ studied. It can promote increase on cardiac damage and a reduction on mutagenic effects of ND, which demonstrated that dehydronandrolone has diverse role on ND effects..

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“…Thus, the stimulated appetite can be the core reason behind the increase in weight of experimental group observed with the drug administration. Older studies have also stated that the nandrolone decanoate produces positive impacts on the body growth of a female rat (Brasil et al, 2015, Bisschop et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

The impact of nandrolone decanoate administration on ovarian and uterine tissues in rat: Luteinizing hormone profile, histopathological and morphometric assessment

Saddick

2018

Saudi Journal of Biological Sciences

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The study had been conducted to evaluate the effects of nandrolone decanoate (abused repeated doses) on female rat's ovary and uterus during administration and withdrawal. The study included 18 rats that were divided into control group (n = 6) and treated group (n = 12). The treated group was injected intramuscular (IM) with nandrolone decanoate (7 mg/kg body weight) for three consecutive days, for two weeks. The study stated that nandrolone decanoate increases the weights of body, ovary, and uterus. Moreover, it has a tendency of bringing upon modifications in the biochemical, histopathological, and morphological makeup of the female reproductive aspects. In conclusion, nandrolone decanoate has been identified as deleterious element for the female rats, and it is suggested that keen observations must be made on the human abusers to control and manage the possible pathologies.

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Nandrolone decanoate induces cardiac and renal remodeling in female rats, without modification in physiological parameters: The role of ANP system

Cited by 20 publications

References 55 publications

Nandrolone Decanoate: Use, Abuse and Side Effects

Nandrolone Decanoate: Use, Abuse and Side Effects

Finasteride promotes worsening of the cardiac deleterious effects of nandrolone decanoate and protects against genotoxic and cytotoxic damage

The impact of nandrolone decanoate administration on ovarian and uterine tissues in rat: Luteinizing hormone profile, histopathological and morphometric assessment

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