Naltrexone and Cognitive Behavioral Coping Skills Therapy for the Treatment of Alcohol Drinking and Eating Disorder Features in Alcohol‐Dependent Women: A Randomized Controlled Trial

O’Malley, Stephanie S.; Sinha, Rajita; Grilo, Carlos M.; Capone, Christy; Farren, Conor K.; McKee, Sherry A.; Rounsaville, Bruce J.; Wu, Rongqian

doi:10.1111/j.1530-0277.2007.00347.x

Cited by 69 publications

(65 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Inhibition of relapse for a prolonged period of time following extinction, as observed in this study, might provide a significant window of opportunity during which additional therapeutic interventions could be introduced to further forestall relapse. For example, stress is a major determinant of relapse (Sinha, 2009) and cognitive behavioral therapies that help to develop coping skills have been effective in treating alcohol abuse (O'Malley et al, 2007). As evidenced by the eventual return to baseline levels of responding toward the end of the reacquisition phase of our study, pharmacologically augmented exposure therapy might be most beneficial if implemented as a recurring treatment strategy for the management of cocaine dependence.…”

Section: Discussionmentioning

confidence: 88%

Glycine Transporter-1 Inhibition Preceding Extinction Training Inhibits Reacquisition of Cocaine Seeking

Achat-Mendes

Dhonnchadha

Platt

et al. 2012

Neuropsychopharmacol

View full text Add to dashboard Cite

Cognitive enhancers that act by increasing glycine transmission might be useful adjuncts to cocaine-cue extinction training to deter relapse. The study investigated the effects of combining treatments of the glycine transporter-1 (GlyT-1) inhibitor, Org24598, with extinction training on the subsequent reacquisition of cocaine self-administration. Squirrel monkeys and rats were trained to selfadminister cocaine under a second-order schedule of intravenous drug injection in which responding was maintained by cocaine injections and a cocaine-paired visual stimulus. During three weekly extinction sessions, saline was substituted for cocaine but responding still produced the cocaine-paired stimulus. Subjects were treated with Org24598 or vehicle, either before or after each extinction session. One week later, cocaine injections were restored, and reacquisition of cocaine self-administration was evaluated over 15 sessions. Compared with vehicle, administration of Org24598 (1.0 mg/kg in monkeys; 3.0 or 7.5 mg/kg in rats) before each extinction session significantly inhibited reacquisition of cocaine self-administration in each species. In contrast, administration of Org24598 (1.0 mg/kg in monkeys) following, rather than preceding, each extinction session did not affect reacquisition compared with vehicle. When extinction training was replaced by cocaine self-administration or abstinence control conditions, treatment with the same doses of Org24598 resulted in reacquisition that was significantly more rapid than the reacquisition observed when Org24598 was administered before extinction training sessions. The results support the potential clinical utility of GlyT-1 inhibitor pretreatments combined with cocaine-cue extinction training to inhibit relapse.

show abstract

Section: Discussionmentioning

confidence: 88%

Glycine Transporter-1 Inhibition Preceding Extinction Training Inhibits Reacquisition of Cocaine Seeking

Achat-Mendes

Dhonnchadha

Platt

et al. 2012

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…Moreover, the majority of the studies evaluated by the meta-analysis did not report the results obtained by female patients in detail, while the few studies in which this information was reported found contrasting results. Namely, the RCT in which only female patients were recruited failed to demonstrate a significant effect of naltrexone [61] . In this RCT, naltrexone did not improve drinking outcomes, although naltrexone delayed the on- set of subsequent drinking days among women who lapsed.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of Medications Approved for the Treatment of Alcohol Dependence and Alcohol Withdrawal Syndrome in Female Patients: A Descriptive Review

Agabio

Pani²,

Preti

et al. 2015

Eur Addict Res

View full text Add to dashboard Cite

The aim of this study was to evaluate whether the number of women recruited for studies to establish the efficacy of medications approved for treatment of alcohol dependence (AD) and of alcohol withdrawal syndrome (AWS) is sufficient to reveal possible gender differences in the response to these medications and in suggesting the use of different doses in female patients. Our results show that the rates of women recruited for studies evaluating the efficacy of disulfiram (1%), benzodiazepines (3%), and anticonvulsants (13%) were too low to establish possible gender differences. The rates of women recruited for studies evaluating the efficacy of acamprosate (22%), naltrexone (23%), and nalmefene (30%) were higher and allowed evaluation of data obtained for female patients. Women receive medications for treatment of AD and/or AWS for which efficacy has been demonstrated in studies in which men were more largely represented.

show abstract

“…Sin embargo, un análisis posterior ha comprobado que entre las mujeres que bebieron durante el tratamiento, las que tomaban naltrexona presentaron un mayor número de días entre el primer consumo y los siguientes días de consumo de alcohol, que las que tomaron placebo 65 .…”

Section: Predictors Of Response To Treatment With Naltrexoneunclassified

“…However another study has shown that among women who drank during the treatment, those who took naltrexone, showed a higher number of days between the first and the next drinking days, in comparison with those who took placebo 65 . Baros, Latham and Anton 66 have proposed that gender differences can be more related to sample size or outcome variables than to pharmacological or biological differences in the response to naltrexone.…”

Section: Predictors Of Response To Treatment With Naltrexonementioning

confidence: 99%

Cambio de paradigma en el tratamiento del alcoholismo de baja gravedad

Guardia-Serecigni¹

2011

Adicciones

View full text Add to dashboard Cite

IntroductionRecent pharmacotherapy findings from new alcohol reduction programmes could change the paradigm of alcohol-dependence treatment. Material and MethodThis study reviews the neurobiological background and pharmacotherapy of alcohol-dependence disorder, focusing on opioid receptor antagonists, abstinence-oriented treatment and moderation-oriented treatment. Results 1.Alcohol-dependence treatment programs show only low to moderate efficacy. 2. Patients usually show low motivation to sustain abstinence but high motivation to reduce alcohol use. 3. A treatment program based on continued reduction of drinking and associated with intermittent treatment with naltrexone can be useful for low-severity alcohol-dependent patients. DiscussionAlthough high severity alcohol-dependent patients should stop drinking alcohol, low severity patients may have the option of reducing their alcohol consumption if they take an opioid antagonist medication every day that they decide to drink alcohol. In the short term, the continuing drinking-reduction programmes may reduce the number of drinks per drinking day and in the long term, they may progressively decrease the obsession for drinking, alcohol seeking behavior, and related medical, behavioral and social disorders. To change the paradigm in the treatment of alcohol-dependence disorder there is a need for further randomized controlled trials in order to assess their efficacy and tolerability.

show abstract

Naltrexone and Cognitive Behavioral Coping Skills Therapy for the Treatment of Alcohol Drinking and Eating Disorder Features in Alcohol‐Dependent Women: A Randomized Controlled Trial

Cited by 69 publications

References 62 publications

Glycine Transporter-1 Inhibition Preceding Extinction Training Inhibits Reacquisition of Cocaine Seeking

Glycine Transporter-1 Inhibition Preceding Extinction Training Inhibits Reacquisition of Cocaine Seeking

Efficacy of Medications Approved for the Treatment of Alcohol Dependence and Alcohol Withdrawal Syndrome in Female Patients: A Descriptive Review

Cambio de paradigma en el tratamiento del alcoholismo de baja gravedad

Contact Info

Product

Resources

About