Naloxone reduces social locomotor activity in rats

Dokla, Carl P.J.

doi:10.1016/0091-3057(92)90501-6

Cited by 14 publications

(2 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Locomotion in a novel environment was measured as previously described (Dokla, ; Gillies, Mylecharane, & Jackson, ; Hoffman, West, & Wise, ; Hoffman & Wise, ; Juárez‐Méndez, Carretero, Martínez‐Tellez, Silva‐Gómez, & Flores, ; Juárez, Silva‐Gómez, Peralta, & Flores, ; Monroy, Hernández‐Torres, & Flores, ; Sánchez, de Jesús Gómez‐Villalobos, Juárez, Quevedo, & Flores, ). First the rats were habituated in the test room for 2 hr, then the animals were placed into the locomotor activity boxes for 120 min.…”

Section: Methodsmentioning

confidence: 99%

Pregnancies alters spine number in cortical and subcortical limbic brain regions of old rats

Flores-Vivaldo

Camacho-Ábrego

Picazo

et al. 2019

Synapse

View full text Add to dashboard Cite

Pregnancy is a complex process, involving a number of hormones and trophic factors, many of which are formed in the placenta. Several of these trophic factors have an effect at the neuronal level, such as BDNF. Consequently, recent reports have shown that exposure to these hormones (estrogen and progesterone) and trophic factors such as BDNF exert a neuroprotective effect. Here, we study the effect of the number of pregnancies on dendritic morphology of aged female rats (18 months of age). Rats of the 18‐month‐old Sprague Dawley strain with zero, one, two, and three gestations were evaluated for locomotor activity, and Golgi–Cox stain was performed to evaluate the dendritic morphology parameters, the number of dendritic spines, total dendritic length, and branching order number. Adult nulliparous rats (3 months of age) were used as another control group. Adult nulliparous and aging rats with two pregnancies showed an increase in locomotor activity. Adult nulliparous showed an increase in the dendritic spine number compared to old nulliparous rats in both layers of the PFC, the DG, and NAcc. Old rats with two and three pregnancies also showed an increase in the number of dendritic spines compared to old nulliparous rats in layers 3 and 5 of the PFC and in the CA1. Aging animals with one pregnancy also showed an increase in dendritic length compared to old nulliparous rats in the CA1. Our results clearly suggest that two and three pregnancies increase the dendritic spines number in the PFC and CA1 of aged female rats.

show abstract

Section: Methodsmentioning

confidence: 99%

Pregnancies alters spine number in cortical and subcortical limbic brain regions of old rats

Flores-Vivaldo

Camacho-Ábrego

Picazo

et al. 2019

Synapse

View full text Add to dashboard Cite

show abstract

“…Panksepp and Bishop (1981)demonstrated that social play results in the release of endogenous opioids in juvenile rats. Apparently, opioid release also contributes to the maintenance of social behavior, as indicated by the effect of the opiate receptor antagonist naloxone in reducing paired locomotor activity and play in rats (Dokla, 1992; Panksepp, Jalowiec, DeEskinazi, & Bishop, 1985). In adult monkeys, grooming behavior was associated with an elevation of cerebrospinal fluid β-endorphin levels (Keverne, Martensz, & Tuite, 1989).…”

mentioning

confidence: 99%

Establishment of a preference by the newborn lamb for its mother: The role of opioids.

Shayit¹,

Nowak²,

Keller³

et al. 2003

Behavioral Neuroscience

View full text Add to dashboard Cite

Mother-young relationships in sheep are characterized by individual recognition and a rapidly developing exclusive bond. The authors examined the role of opioids in establishment of the lamb's preference for its mother. Newborn lambs received the opioid receptor antagonist naltrexone (0.0, 1.5, or 3.0 mg/kg i.p.), and lambs were tested at 24 hr and 48 hr of age. At 24 hr, controls spent significantly more time near the mother than near an alien ewe; no significant difference was obtained for the naltrexone-treated groups. The effect of naltrexone persisted at 48 hr. No other significant behavioral difference was observed. Results support the hypothesis that opioids mediate the establishment of mother preference and the view that positive affect associated with social attachment and maternal care may be modulated by opioids.

show abstract

Effects of opioid receptor blockade on the social behavior of rhesus monkeys living in large family groups

Martel

Nevison

Simpson

et al. 1995

Developmental Psychobiology

108

View full text Add to dashboard Cite

Rhesus monkeys of 9 weeks, 48 weeks, 100 weeks, 150 weeks of age (young subjects), or mature parous females that were not lactating were given acute single doses of the opioid antagonist naloxone (0.5 mglkg) and vehicle on different days and observed in their familial social groups. Naloxone increased the occurrence of affiliative behaviors. Young subjects spent more time in contact with their mothers but showed no changes in social grooming. Maternal contact was actively sought through contact vocalizations, decreasing proximity, and, for the youngest infants, increased attempts to suckle. Mature females made more solicitations for grooming and received more grooming from their companions. These results are interpreted in terms of naloxone blocking the positive affect arising from social contact and thus causing subjects to seek further affiliative comfort. 0 1995 John Wiley & Sons, Inc.

show abstract

Naloxone reduces social locomotor activity in rats

Cited by 14 publications

References 74 publications

Pregnancies alters spine number in cortical and subcortical limbic brain regions of old rats

Pregnancies alters spine number in cortical and subcortical limbic brain regions of old rats

Establishment of a preference by the newborn lamb for its mother: The role of opioids.

Effects of opioid receptor blockade on the social behavior of rhesus monkeys living in large family groups

Contact Info

Product

Resources

About