Naked-eye detection of pandemic influenza a (pH1N1) virus by polydiacetylene (PDA)-based paper sensor as a point-of-care diagnostic platform

A review on advances in methods for modification of paper supports for use in point-of-care testing

“…Finally, paperbased modification approaches will play a greater role in POCT. For example, novel properties paper will be used for POCT detection (e.g., polydiacetylene-based paper assay shows chromatic properties and then it can be used for naked-eye detection of pandemic influenza a virus [147]). Filter paper after wax patterned modified with CoPc/IL/G for the glucose detection [136] Composites materials can be utilized to increase the features of papers (e.g., graphene oxide/thionine/gold nanoparticles nanocomposites have been used for increase the adsorption ability of biomolecules on paper for cancer antigen 125 detection [148]).…”

A novel receptor-free polydiacetylene nanofiber biosensor for detecting E. coli via colorimetric changes

“…sensors provide advantages in biomedical applications especially due to a high degree of cell mimicry, they are often unstable due to the aggregation and precipitation of PDA molecules 16 . The substrate-based PDA sensors overcome this drawback because they are relatively stable and sensitive in many sensing applications 16 .…”

“…sensors provide advantages in biomedical applications especially due to a high degree of cell mimicry, they are often unstable due to the aggregation and precipitation of PDA molecules 16 . The substrate-based PDA sensors overcome this drawback because they are relatively stable and sensitive in many sensing applications 16 . Nevertheless, to detect pathogens such as bacteria via PDA based sensors, both substrate and solution-based PDAs were reported that can sense either the bacterial cell or the materials bacteria secretes into the environment during the growth phase.…”

Recent applications of paper‐based point‐of‐care devices for biomarker detection

“…Furthermore, photoelectrochemical‐PAD based on TiO 2 /Bi 4 NbO 8 Cl/CoPi has been proposed for ultrasensitive detection of β ‐human chorionic gonadotrophin providing a LOD of 0.005 IU/L . Interestingly, a laser‐cut‐PAD using pseudo‐particles as capture antigen was fabricated for detection of chikungunya virus and a polydiacetylene‐based colorimetric biosensor was developed to detect pandemic influenza (pH1N1) virus by naked‐eye detection .…”