Nail Unit Squamous Cell Carcinoma: Updates on Diagnosis, Surgical Approach, and the Use of Mohs Micrographic Surgery

Dany, Mohammed

doi:10.12788/cutis.0122

Cited by 5 publications

(8 citation statements)

References 24 publications

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“…Treatment options include wide local excision, digital amputation, cryotherapy, topical modalities, and recently Mohs surgery. 3 The incidence of SCCNU was approximately 0.0012% in-hospital patients and 0.028% in dermatology patients. 4 It is more common in middle-aged men, and the peak age of onset is between 50 and 69 years old.…”

Section: Discussionmentioning

confidence: 95%

Squamous Cell Carcinoma of the Nail Unit After Trauma: A Case Report

Xu¹,

Mao²,

Wen³

2022

CCID

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Squamous cell carcinoma of the nail unit (SCCNU) is a relatively uncommon tumor with a low rate of metastasis. SCCNU presents with nonspecific symptoms and signs, it is frequently misdiagnosed by dermatologists or surgeons. We report a patient with right-hand ring subungual squamous cell carcinoma who received inappropriate treatment due to a long-term misdiagnosis following trauma. This patient had been treated with acitretin combined with cefaclor, and a certain curative effect was seen, but finally, wide local excision was performed.

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Section: Discussionmentioning

confidence: 95%

Squamous Cell Carcinoma of the Nail Unit After Trauma: A Case Report

Xu¹,

Mao²,

Wen³

2022

CCID

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“…Nail unit SCCs may have a strong impact on the patient's quality of life, social behaviour and working activity due to the high rate of local recurrences and possible bone involvement. Phalangeal amputation is mandatory in case of signs of bone spreading detected at radiological images or histologically observed performing Mohs micrographic surgery 2,5 . There is therefore a demand for patient‐tailored therapies in order to reduce the postoperative burden.…”

Section: Discussionmentioning

confidence: 99%

“…Phalangeal amputation is mandatory in case of signs of bone spreading detected at radiological images or histologically observed performing Mohs micrographic surgery. 2,5 There is therefore a demand for patient-tailored therapies in order to reduce the postoperative burden. For this reason, it is crucial to investigate the molecular characterization of this neoplasm, even when localized in special sites, such as the nail unit.…”

Section: Discussionmentioning

confidence: 99%

“…1 Despite this, metastasis and deaths are extremely rare. 5 The improvements in high-throughput molecular techniques All clinical-pathological investigations were conducted according to the principles of the Declaration of Helsinki, and all information regarding the human material used in this study was managed using anonymous numerical codes. Informed consent was obtained for all patients, and the study had been previously approved by the internal committee of the IRCCS Policlinico di Sant'Orsola, University of Bologna (SkinCancer-19).…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, NU SCC may be misdiagnosed as benign lesions, including warts or onychomycosis 1 . Despite this, metastasis and deaths are extremely rare 5 …”

Section: Introductionmentioning

confidence: 99%

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Mutational landscape in squamous cell carcinoma of the nail unit

Dika

Biase

Lambertini

et al. 2022

Experimental Dermatology

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Squamous cell carcinoma (SCC) is the most common malignancy of the nail unit. Pathogenetic mechanisms are yet to be determined, and a deeper molecular characterization of this disease is still necessary. The aim was to obtain a molecular characterization of NU SCC samples using an NGS approach to identify the genetic drivers involved in this tumor. The presence of HPV infection was also assessed. Furthermore, the mutational status was correlated with specific clinical‐pathological features for a better insight into the carcinogenesis of this uncommon tumor. We analysed twenty paraffin‐embedded nail unit SCC samples from patients diagnosed with primary SCC of the nail unit by next genome sequencing. In the 20 tested samples, the neoplastic cells enrichment ranged from 10% to 50% (mean value: 25.7%). In 14/20 cases (70.0%), at least one mutation was detected; whereas in the other six cases (30.0%), no alterations were observed (‘wild‐type/WT cases’). Overall, a total of 23 mutations were identified in the 20 specimens. TP53 was the most mutated gene (6/20 cases, 30.0%), while cKit, GNAS, EGFR, DICER1 and CTNNB1 were observed in one sample each (5.0%). No clinical‐pathological parameters (age, sex, depth of invasion‐DOI, histological subtype, grading and HPV) were significantly associated with the mutational status. The nail unit SCC mutational landscape appeared to be heterogeneous, favouring the hypothesis of a complex pathogenesis and an interaction of multiple elements, including HPV infections. This wealth of information undoubtedly improves our understanding of SCC biology.

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Cirugía de la uña (salvo la onicocriptosis y la distrofia ungueal)

Delaplace,

Le Helloco

2024

EMC - Podología

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Nail Unit Squamous Cell Carcinoma: Updates on Diagnosis, Surgical Approach, and the Use of Mohs Micrographic Surgery

Cited by 5 publications

References 24 publications

Squamous Cell Carcinoma of the Nail Unit After Trauma: A Case Report

Squamous Cell Carcinoma of the Nail Unit After Trauma: A Case Report

Mutational landscape in squamous cell carcinoma of the nail unit

Cirugía de la uña (salvo la onicocriptosis y la distrofia ungueal)

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