Nail toxicity in a patient being treated with immune checkpoint inhibitors

Nail toxicity with nail bed ulceration associated with pembrolizumab

“…Four reports of cases of nail toxicity caused by pembrolizumab have been published, [1][2][3] all of which occurred in patients older than 70 years; the number of cycles administered until nail toxicity were observed ranged from 7 to 29. Although their symptoms were confined to the toes, two of these cases had ulcerated nail beds and most of the nails did not regrow, 1 similar to the present patient.…”