Nail Manifestations in COVID-19: Insight into a Systemic Viral Disease

Preda-Naumescu, Ana; Penney, Kayla; Pearlman, Ross L; Daniel, C. Ralph; Nahar, Vinayak K.

doi:10.1159/000518087

Cited by 8 publications

(21 citation statements)

References 15 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nail manifestations associated with COVID-19 included a red half-moon sign, transverse orange nail lesions, Mees’ lines, and Beau’s lines [ 13 ]. No nail disorder was observed in any of our patients who had Covid-19.…”

Section: Discussionmentioning

confidence: 99%

Follow-up of Favipiravir-Induced Nail Fluorescence: Implications for Nail and Drugs

Güder

Özünal

2023

Dermatol Pract Concept

View full text Add to dashboard Cite

Introduction: Favipiravir creates fluorescence on nails, which can be seen with Wood's light. Objectives: The objectives of this study are to examine the properties of fluorescence in the nail due to favipiravir and to observe whether other drugs also produce fluorescence in the nail. Methods: The research is descriptive, prospective, and quantitative. This study recruited 30 healthcare workers who received favipiravir treatment and 30 volunteers who took or did not take any medication except favipiravir from March 2021 to December 2021. Fingernails of the patients and control groups were examined under Wood's light in the darkroom. If fluorescence was observed in the fingernails, we followed up once a month until the fluorescence disappeared. We calculated the nail growth rate by dividing the distance of nail fluorescence from the proximal nail fold by the number of days since favipiravir was started. Results: We found nail fluorescence in all patients receiving a loading dose of favipiravir. The fluorescence in the nail decreased and disappeared in the 3rd month. The average nail growth rate at the first visit was 0.14 mm/day. The nail growth rate at the second visit was 0.10 mm/day. A statistically significant difference was found between the first and second visit nail growth rates (z: -2.576; p=0.010<0.05). We found that other drugs did not produce any fluorescence in the nail. Conclusions: Nail fluorescence induced by favipiravir is dose-dependent and decreases in intensity over time. Nail fluorescence due to favipiravir is likely due to the active ingredient of the drug.

show abstract

Section: Discussionmentioning

confidence: 99%

Follow-up of Favipiravir-Induced Nail Fluorescence: Implications for Nail and Drugs

Güder

Özünal

2023

Dermatol Pract Concept

View full text Add to dashboard Cite

show abstract

“…Three patients (8.8%) receiving the Pfizer vaccine reported pernio-like lesions with the first dose and 2 patients (5.0%) reported lesions with the second dose [ 9 ]. Periungual pernio-like erythema has also been reported as a nail manifestation of COVID-19 [ 10 ]. The authors emphasize that patients may present with a nail complaint given involvement of the proximal and lateral nail folds in which pernio-like lesions should be on the differential in the appropriate clinical context.…”

Section: Discussionmentioning

confidence: 99%

Vaccine Toes Are the New COVID Toes

Hodge

Daniel

Elewski

2022

Skin Appendage Disord

Self Cite

View full text Add to dashboard Cite

Introduction: Pernio-like lesions were reported as dermatologic manifestations of COVID-19 as early as May of 2020. Since mRNA COVID-19 vaccines were introduced in December 2020, 9 reports of vaccine-associated pernio-like lesions have been presented in the medical literature. Case Presentation: A male in his 60s developed pernio-like lesions on the bilateral toes approximately 1 week after receiving the second dose of the Pfizer-BioNTech COVID-19 mRNA vaccine. His symptoms resolved in 6 weeks. Conclusion: The rising number of reports of pernio-like lesions associated with COVID-19 vaccination underlines the importance of the pathophysiological state of the vaccinated patient and how it relates to dermatological manifestations. Pernio-like lesions are thought to represent a robust host immune antiviral response related to production of interferon-1 in the setting of primary infection; incidences occurring after vaccination further support this theory. Unfortunately, media-generated reports of such reactions have the potential to inflame distrust and fear of the vaccine among the general public. Given the previous media interest in reporting pernio-like lesions with primary COVID-19 infection, it is reasonable to expect overrepresentation of pernio-like lesions with vaccination. There appears to be a general increase in patient distrust of evidence-based medicine and thus “COVID toes” represent an important intersection at which the clinician can capture the patient’s trust by providing education and counseling.

show abstract

“…Zu nennen wären beispielsweise das Erythema exsudativum multiforme (EEM) [ 14 , 34 ] und die palmoplantare Erythrodysästhesie [ 30 ]. Ferner wurde ein breites Spektrum an Pathologien der Hautanhangsgebilde beschrieben, wie beispielsweise Nagelveränderungen in Form von Mees-Bändern [ 17 , 31 ] und die Erstmanifestation einer Alopecia areata 1 Monat nach Infektion [ 9 ].…”

Section: Die 5 Häufigsten Hautveränderungen Bei Covid‑19unclassified