Nail Fold Capillaroscopy and Echocardiography in Mild-to-Moderate Hypertension Treated with Cilazapril plus Hydrochlorothiazide

Weinbacher, M; Martina, Benedict; Gasser, P.; Kohler, Michaela; Bart, T.

doi:10.1097/00005344-199406243-00015

Cited by 4 publications

(3 citation statements)

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“…No constraint on drug therapy or smoking habit was imposed due to the fact that the literature registers no induction of NFC abnormality by these agents. [28][29][30] In the present series we observed association between RP and cutaneous involvement, and between RP and anti-U1-RNP antibodies, ndings previously reported in the literature. 31 Altered nailfold capillary morphology has been reported in 40 -90% of SLE patients.…”

Section: Discussionsupporting

confidence: 79%

Scleroderma-like nailfold capillaroscopic abnormalities are associated with anti-U1-RNP antibodies and Raynaud's phenomenon in SLE patients

Furtado¹,

Pucinelli²,

Cristo³

et al. 2002

Lupus

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This study aimed to evaluate the association between nailfold capillary abnormalities and the presence of Raynaud's phenomenon (RP), anti-U1-RNP, and anti-cardiolipin (aCL) antibodies in SLE patients. One-hundred SLE patients were studied. Widefield nailfold capillaroscopy was considered abnormal according to five criteria. Intercapillary distance, capillary width and capillary length were registered by videomorphometry in two fingers in 100 patients and in four fingers in 40 of these patients. Both the presence of alterated capillaroscopy and the presence of scleroderma-pattern (SD-pattern), characterized by the presence of avascular areas and enlarged or giant loops, were associated with the isolated presence of RP (P < 0.001) or anti-U1-RNP antibodies (P < 0.01), as well as with the simultaneous presence of RP and anti-U1RNP antibodies (P < 0.001). There was a negative association between the presence of aCL antibodies and SD-pattern (P < 0.05). Higher figures for the videomorphometric parameters capillary width, intercapillary distance and capillary length (measured on four fingers) were observed in patients with RP. Patients presenting both RP and anti-U1-RNP antibodies showed higher figures for intercapillary distance and capillary width. This study demonstrated significant association between nailfold capillaroscopic abnormalities and either RP or anti-U1-RNP antibodies in SLE patients. The association of RP, anti-U1-RNP antibodies, and 'scleroderma-like' findings on nailfold capillaroscopy (SD-pattern) in patients with SLE may suggest a new SLE subset with subclinical features of systemic sclerosis.

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Section: Discussionsupporting

confidence: 79%

Scleroderma-like nailfold capillaroscopic abnormalities are associated with anti-U1-RNP antibodies and Raynaud's phenomenon in SLE patients

Furtado¹,

Pucinelli²,

Cristo³

et al. 2002

Lupus

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“…In consequence the first critical step of any NP administration into the human body is the dilution into 4.7-5 l of blood. The next step is that the NPs, once injected into the blood stream, move with a output speed of 0.3 m/s into the aorta coming from the heart and a velocity of 0.6 ± 0.4 mm/s in capillary vessels [35]. Initially injected in a bolus within the blood flow NPs become with time homogenously distributed over around 100,000 km of blood vessels and a total surface area of 8000 m 2 of vessel walls [5].…”

Section: Physics Comes Into the Gamementioning

confidence: 99%

Challenges in drug delivery to the brain: Nature is against us

Krol

2012

Journal of Controlled Release

132

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“…Treatment: Few studies have examined the effects of antihypertensive medication on capillary function as assessed by capillaroscopy. Neither the ACE inhibitors cilazapril or enalapril, the calcium antagonist amlodipine nor the selective T‐type calcium channel blocker mibefradil changed resting CBV significantly in patients with hypertension [88 ‐ 90]. This is in contrast to the 40% increase in CBV seen 10 min after the sublingual administration of nifedipine to healthy controls [91].…”

mentioning

confidence: 99%

Capillaroscopy and the measurement of capillary pressure

Shore

2000

Brit J Clinical Pharma

121

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Capillaries play a critical role in cardiovascular function as the point of exchange of nutrients and waste products between the tissues and circulation. Studies of capillary function in man are limited by access to the vascular bed. However, skin capillaries can readily be studied by the technique of capillaroscopy which enables the investigator to assess morphology, density and blood¯ow velocity. It is also possible to estimate capillary pressure by direct cannulation using glass micropipettes. This review will describe the techniques used to make these assessments and will outline some of the changes that are seen in health and disease.

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Nail Fold Capillaroscopy and Echocardiography in Mild-to-Moderate Hypertension Treated with Cilazapril plus Hydrochlorothiazide

Cited by 4 publications

References 0 publications

Scleroderma-like nailfold capillaroscopic abnormalities are associated with anti-U1-RNP antibodies and Raynaud's phenomenon in SLE patients

Scleroderma-like nailfold capillaroscopic abnormalities are associated with anti-U1-RNP antibodies and Raynaud's phenomenon in SLE patients

Challenges in drug delivery to the brain: Nature is against us

Capillaroscopy and the measurement of capillary pressure

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