NaDyF<sub>4</sub>Nanoparticles as T<sub>2</sub>Contrast Agents for Ultrahigh Field Magnetic Resonance Imaging

Das, Gautom Kumar; Johnson, Noah J. J.; Cramen, Jordan; Błasiak, Barbara; Latta, Peter; Tomanek, Bogusław; Veggel, Frank C. J. M. van

doi:10.1021/jz201664h

Cited by 150 publications

(198 citation statements)

References 36 publications

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“…The efficiency of T 2 CAs depends on r 2 more than on r 1 . It has been reported that the higher the r 2 /r 1 ratio the better the efficiency of a negative CA [31,32]. r 1 and r 2 relaxivities are dependent on the nanoparticle size in a direct proportion relationship.…”

Section: Discussionmentioning

confidence: 99%

“…It seems that this behavior extends to higher frequencies given the slightly lower values of r 2 obtained by our bioferrofluids as compared with Endorem at high frequency (200 MHz). The efficiency of a T 2 contrast depends on its r 2 relaxivity as well as the r 2 /r 1 ratio: the higher the ratio of r 2 /r 1 , the better the efficiency of a T 2 CA [31,33]. The calculation of the r 2 /r 1 ratio for both bioferrofluids and Endorem shows that our bioferrofluids have a higher r 2 /r 1 ratio than Endorem and this could be an advantage of our bioferrofluid compared with commercial Endorem.…”

Section: Discussionmentioning

confidence: 99%

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Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T ₂ Contrast Agent for MRI and their Uptake in Liver

et al. 2017

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Aim:To study the efficiency of multifunctional polymer-based superparamagnetic iron oxide nanoparticles (bioferrofluids) as a T 2 magnetic resonance contrast agent and their uptake and toxicity in liver. Materials & methods: Mice were intravenously injected with bioferrofluids and Endorem R . The magnetic resonance efficiency, uptake and in vivo toxicity were investigated by means of magnetic resonance imaging (MRI) and histological techniques. Results: Bioferrofluids are a good T 2 contrast agent with a higher r 2 /r 1 ratio than Endorem. Bioferrofluids have a shorter blood circulation time and persist in liver for longer time period compared with Endorem. Both bioferrofluids and Endorem do not generate any noticeable histological lesions in liver over a period of 60 days post-injection. Conclusion: Our bioferrofluids are powerful diagnostic tool without any observed toxicity over a period of 60 days post-injection.Lay abstract: Several superparamagnetic iron oxide nanoparticles (SPIONs) preparations have been approved by US FDA for clinical use as MRI contrast agents. In recent years, we have been developing a synthetic multifunctional platform for SPIONs based on the use of polymers. In this report, we explored the diagnostic potential of these nanoparticles (herein called bioferrofluids) as an MRI contrast agent and their uptake in liver, without neglecting their toxicological effects. Results show that our bioferrofluids are a good T 2 contrast agent without any observed toxicity in liver.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T ₂ Contrast Agent for MRI and their Uptake in Liver

et al. 2017

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“…62 Dy 3+ has been used as a chelate (eg, Dy 3+ -DTPA) or as nanoparticles (eg, Dy 2 O 3 ). 63,64 One type of Dy 3+ -based nanoparticles are β-NaDyF 4 nanoparticles; their relaxivity has been studied at 3 and 9.4 T in nanoparticles of 5.4, 9.8, and 20.3 nm.…”

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confidence: 99%

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Estelrich¹,

Sánchez-Martín²,

Busquets³

2015

IJN

275

106

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Magnetic resonance imaging (MRI) has become one of the most widely used and powerful tools for noninvasive clinical diagnosis owing to its high degree of soft tissue contrast, spatial resolution, and depth of penetration. MRI signal intensity is related to the relaxation times ( T 1 , spin–lattice relaxation and T 2 , spin–spin relaxation) of in vivo water protons. To increase contrast, various inorganic nanoparticles and complexes (the so-called contrast agents) are administered prior to the scanning. Shortening T 1 and T 2 increases the corresponding relaxation rates, 1/ T 1 and 1/ T 2 , producing hyperintense and hypointense signals respectively in shorter times. Moreover, the signal-to-noise ratio can be improved with the acquisition of a large number of measurements. The contrast agents used are generally based on either iron oxide nanoparticles or ferrites, providing negative contrast in T 2 -weighted images; or complexes of lanthanide metals (mostly containing gadolinium ions), providing positive contrast in T 1 -weighted images. Recently, lanthanide complexes have been immobilized in nanostructured materials in order to develop a new class of contrast agents with functions including blood-pool and organ (or tumor) targeting. Meanwhile, to overcome the limitations of individual imaging modalities, multimodal imaging techniques have been developed. An important challenge is to design all-in-one contrast agents that can be detected by multimodal techniques. Magnetoliposomes are efficient multimodal contrast agents. They can simultaneously bear both kinds of contrast and can, furthermore, incorporate targeting ligands and chains of polyethylene glycol to enhance the accumulation of nanoparticles at the site of interest and the bioavailability, respectively. Here, we review the most important characteristics of the nanoparticles or complexes used as MRI contrast agents.

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“…Other T 2 -based NPs contrast agents with improved magnetic and physicochemical properties have been developed such as paramagnetic dysprosium nanomaterials (nanoparticles and nanorods) [104,105]. …”

Section: Figure 1 Herementioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

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The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in synthesis protocol and characterization of these materials whereas toxicological issues are sometimes incomplete. Nanoparticle-based contrast agents tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of 2 imaging modalities. Multimodal nanoparticles (NPs) are much more efficient than conventional molecular-scale contrast agents. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides specific applications for classical imaging, (MRI, PET, CT, US, PAI) are also mentioned less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA).Perspectives on multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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NaDyF₄Nanoparticles as T₂Contrast Agents for Ultrahigh Field Magnetic Resonance Imaging

Cited by 150 publications

References 36 publications

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T ₂ Contrast Agent for MRI and their Uptake in Liver

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T ₂ Contrast Agent for MRI and their Uptake in Liver

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

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NaDyF4Nanoparticles as T2Contrast Agents for Ultrahigh Field Magnetic Resonance Imaging

Cited by 150 publications

References 36 publications

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T 2 Contrast Agent for MRI and their Uptake in Liver

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T 2 Contrast Agent for MRI and their Uptake in Liver

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

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Product

Resources

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NaDyF₄Nanoparticles as T₂Contrast Agents for Ultrahigh Field Magnetic Resonance Imaging

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T ₂ Contrast Agent for MRI and their Uptake in Liver

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T ₂ Contrast Agent for MRI and their Uptake in Liver