NADPH-d activity in the islands of Calleja: a regulatory system of blood flow to the ventral striatum/pallidum?

Meyer, Gundela; González‐Hernández, Tomás; Galindo-Mireles, Delia; Carrillo-Padilla, Francisco Javier; Ferres-Torres, R

doi:10.1097/00001756-199406020-00032

Cited by 20 publications

(13 citation statements)

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“…Unfortunately, the present study adds little to a better understanding of the granule cell islands (see also Talbot et al, 1988b;MacGibbon et al, 1994;Meyer et al, 1994;Halliwell and Horne, 1995;de Vente et al, 1998). The demonstration of a small but distinct population of Cabpositive granule cells supports the Golgi analysis of Millhouse (1987) showing two populations of cells in the rat's Callejal complex and numerous spine-poor and a few spine-rich granule cells.…”

Section: Tuberculo-callejal Nuclear Complexsupporting

confidence: 53%

“…As in the rat, the neuropil in the tenrec's granule cell compartment also stains for NADPhD (Vincent and Kimura, 1992;Halliwell and Horne, 1995). However, we failed to label the granule cell perikarya (Meyer et al, 1994;Rodrigo et al, 1994; but see de Vente et al, 1998). Also, we cannot clarify whether or not the granule cell islands receive an input from the olfactory bulb.…”

Section: Tuberculo-callejal Nuclear Complexmentioning

confidence: 60%

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Basal telencephalic regions connected with the olfactory bulb in a Madagascan hedgehog tenrec

Künzle

Radtke‐Schuller

2000

J. Comp. Neurol.

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In an attempt to gain insight into the organization and evolution of the basal forebrain, the region was analysed cytoarchitecturally, chemoarchitecturally, and hodologically in a lower placental mammal, the lesser hedgehog tenrec. Particular emphasis was laid on the subdivision of the olfactory tubercle, the nuclear complex of the diagonal band, and the cortical amygdala. The proper tubercule and the rostrolateral tubercular seam differed from each other with regard to their immunoreactivity to calbindin and calretinin, as well as their afferents from the piriform cortex. Interestingly, the tubercular seam showed similar properties to the dwarf cell compartment, located immediately adjacent to the islands of Calleja. The most prominent input to the olfactory bulb (OfB) originated from the diagonal nuclear complex. This projection was ipsilateral, whereas the bulbar afferents from the hypothalamus and the mesopontine tegmentum were bilateral. The amygdala projected only sparsely to the OfB, but received a prominent bulbar projection. An exception was the nucleus of the lateral olfactory tract, which was poorly connected with the OfB. Unlike other species with an accessory OfB, the projections from the tenrec's main OfB did not show a topographic organization upon the lateral and medial olfactory amygdala. However, there was an accessory amygdala, which could be differentiated from the lateral nuclei by its intense reaction to NADPh-diaphorase. This reaction was poor in the diagonal nuclear complex as in monkey but unlike in rat. The variability of cell populations and olfactory bulb connections shown here may help to clarify both phylogenetic relationships and the significance of individual basal telencephalic subdivisions.

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Section: Tuberculo-callejal Nuclear Complexsupporting

confidence: 53%

Section: Tuberculo-callejal Nuclear Complexmentioning

confidence: 60%

Basal telencephalic regions connected with the olfactory bulb in a Madagascan hedgehog tenrec

Künzle

Radtke‐Schuller

2000

J. Comp. Neurol.

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“…The 1Cj, situated in the olfactory tubercles, are rather highly developed in the human brain. Our finding of a lack of Fos-positive neurons in the 1CI on the lesioned brain side suggests further parallels of this PD model to the vasomotor deficiency found in the human disease [9 ]. Striatal neurons of rats do not normally express Fos-immunoreactivity [12 ], whereas many neurons in other brain structures (such as in the VLM, NTS, LC, VLPAG, Pa, and SO) show a number of immunostained nuclei [13].…”

Section: Discussionsupporting

confidence: 67%

“…This connection is characteristic both of the PD-suffering humans and of our experimental animals. In earlier studies of the NADPH-d activity in the ICj of rats, the close structural and functional relationship between the intensely positive granule cells of these structures and the arteria and arterioles supplying the ventral striatum and ventral pallidum has been demonstrated [9 ]. These neurons are innervated by ventral pallidum cells.…”

Section: Discussionmentioning

confidence: 93%

“…These neurons are innervated by ventral pallidum cells. In addition, ICj afferents come from dopaminergic and noradrenergic brain centers [9,10 ]. Based on the vasodilatory properties of NO and the fact (judged from NADPH-d histochemical staining) that NO-synthesizing cells are grouped around arterioles, the suggestion has been made that close anatomical relations of the blood vessels to the neurons in the ICI imply a local neuronal control of the blood flow to these structures.…”

Section: Discussionmentioning

confidence: 99%

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Suppression of activation of c-fos protein in the striatum by systemic administration of nitroglycerin in a rat model of Parkinson’s disease

et al. 1998

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We found sustained activation of the proto-oncogene c-los in neurons of the medial and dorsal neostriatum and suppression of this activation in NO-synthase (NOS)-containing cells within the islands of Calleja after unilateral lesions of the dopaminergic mestmtriatal system induced by 6-hydroxydopamine (6-OHDA). Systemic administration of nitroglycerin (NTG) resulted in a decreased expression of c-Fos protein in the dorsal part of the denervated neostriatum: respective numbers of Fos-positive neuronal nuclei were 420.71 _+_ 21.32 in control and 141.38 _+ 11.48 after NTG injection (the mean numbers in 50-/~m-thlck slices). However, other brain structures, NTG evoked sustained expression of c-Fos protein in the groups of NOS-containing neurons and sources of catecholaminergic projections involved in the control of cardiovascular reactions. We hypothesize that systemic administration of an NO donor and a potent vasodilator, NTG, partially normalized an excessively increased glutamate level in the denervated neostriarum manifested in c-Fos protein expression.

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Histochemistry of nitric oxide synthase in the nervous system

1995

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Nitric oxide synthase, which generates the physiological messenger molecule nitric oxide, and its associated NADPH diaphorase (NADPHd) activity are distributed throughout selective neuronal populations of the central and peripheral nervous system. Considerable evidence has been accumulated to indicate that NADPHd activity labels cells lacking neuronal nitric oxide synthase, i.e., the specificity of the reaction has to be considered for the reliable detection of the enzyme in neuronal but also non-neuronal tissue. In the present review, critical aspects of nitric oxide synthase visualization in neurones, using its NADPHd activity, are discussed. Furthermore, the organization of the central and peripheral nitric oxide synthase-containing neuronal systems is described. Nitric oxide synthase is present in local cortical and striatal neurones, hypothalamic magnocellular neurones, mesopontine cholinergic neurones, cerebellar interneurones, preganglionic sympathetic and parasympathetic neurones, neurones in parasympathetic autonomic and enteric ganglia and primary viscero-afferent neurones. Finally, injury-related alterations in nitric oxide synthase activity are briefly outlined. In this respect, the histochemistry of nitric oxide synthase may represent a valuable marker for neurochemical, if not structural, alterations observed in neural diseases, regeneration and transplantation.

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NADPH-d activity in the islands of Calleja: a regulatory system of blood flow to the ventral striatum/pallidum?

Cited by 20 publications

References 0 publications

Basal telencephalic regions connected with the olfactory bulb in a Madagascan hedgehog tenrec

Basal telencephalic regions connected with the olfactory bulb in a Madagascan hedgehog tenrec

Suppression of activation of c-fos protein in the striatum by systemic administration of nitroglycerin in a rat model of Parkinson’s disease

Histochemistry of nitric oxide synthase in the nervous system

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