NAD + dependent deacetylase Sirtuin 5 rescues the innate inflammatory response of endotoxin tolerant macrophages by promoting acetylation of p65

Qin, Ken; Han, Chaofeng; Zhang, Hua; Li, Tianliang; Li, Nan; Cao, Xuetao

doi:10.1016/j.jaut.2017.04.006

Cited by 55 publications

(63 citation statements)

References 39 publications

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“…Acetylation is an important protein posttranslational modification that was first found on histones. A large number of nonhistone modifications has been found in many species, such as humans (Li et al., ), mice (Nallamilli et al., ), and B. mori (Zhou et al., ), playing important biological and physiological functions, such as regulation of tumorigenesis (Di Martile, Del Bufalo, & Trisciuoglio, ), lipid biosynthesis (Wang, Guo, Liang, Chi, & Liu, ), and rescue of inflammation (Qin et al., ). Protein acetylation is catalyzed by acetyltransferase.…”

Section: Discussionmentioning

confidence: 99%

Cloning, expression profiling, and acetylation identification of alpha‐tubulin N‐acetyltransferase 1 from Bombyx mori

Zhou

Cheng

et al. 2018

Arch Insect Biochem Physiol

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Alpha-tubulin N-acetyltransferase 1 (ATAT1) is an acetyltransferase specific to α-tubulin and performs important functions in many cellular processes. Bombyx mori is an economic insect and also known as a model lepidoptera insect. In this study, we cloned a B. mori ATAT1 gene (BmATAT1) (Gen Bank accession number: XP_004932777.1). BmATAT1 contained an open reading frame (ORF) of 1,065 bp encoding 355 amino acids (aa). Expression profiling of BmATAT1 protein showed that the expression levels of BmATAT1 at different developmental stages and different tissues in fifth-instar larvae differ. BmATAT1 was highly expressed at the egg stage and in the head of the fifth-instar larvae. Subcellular localization showed that BmATAT1 was distributed in the cytoplasm and nucleus. Furthermore, BmATAT1 may lead to time-dependent induction of cell cycle arrest in the G2/M phase by flow cytometry analysis. Interestingly, using site-specific mutation, immunoprecipitation, and Western blotting, we further found a BmATAT1 acetylated site at K156, suggesting that this acetyltransferase could be regulated by acetylation itself.

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Section: Discussionmentioning

confidence: 99%

Cloning, expression profiling, and acetylation identification of alpha‐tubulin N‐acetyltransferase 1 from Bombyx mori

Zhou

Cheng

et al. 2018

Arch Insect Biochem Physiol

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“…Although reduction of Sirt1/2 expression increased IL‐6 mRNA expression, Sirt5 targeting also down‐regulated IL‐6 mRNA. Accordingly, Sirt5 –/– mice show a reduced inflammatory cytokine response during sepsis . Sirt6 is important for TNF‐α production and dendritic cell function .…”

Section: The Role Of Other Sirtuins In the Immune Systemmentioning

confidence: 99%

“…The role of Sirt4 in the immune system is relatively unknown, through Sirt4 has been suggested to be important to recover monocyte function during sepsis . Sirt5 has an interesting effect on inflammation by competing with Sirt2 and blocking deacetylation of p65 at K310, the same amino acid targeted by Sirt1, in turn causing cytokine production and inducing an inflammatory response in vivo . In fact, Sirt5 had notably opposing expression levels and effects when compared to Sirt1 and Sirt2 on inflammation arising from peritoneal macrophages .…”

Section: The Role Of Other Sirtuins In the Immune Systemmentioning

confidence: 99%

“…79 In fact, Sirt5 had notably opposing expression levels and effects when compared to Sirt1 and Sirt2 on inflammation arising from peritoneal macrophages. 79 Although reduction of Sirt1/2 expression increased IL-6 mRNA expression, Sirt5 targeting also down-regulated IL-6 mRNA. Accordingly, Sirt5 -/mice show a reduced inflammatory cytokine response during sepsis.…”

Section: The Role Of Other Sirtuins In the Immune Systemmentioning

confidence: 99%

“…Accordingly, Sirt5 -/mice show a reduced inflammatory cytokine response during sepsis. 79 Sirt6 is important for TNF-production 80 and dendritic cell function. 81 Sirt7 -/mice show a shortened lifespan and due to cardiac failure, cardiac myocyte apoptosis mediated by p53 hyperacetylation, with myocardial infiltrates of granulocytes and T cells.…”

Section: The Role Of Other Sirtuins In the Immune Systemmentioning

confidence: 99%

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Sirtuin-1 in immunotherapy: A Janus-headed target

Chadha

Wang

Hancock

et al. 2019

Journal of Leukocyte Biology

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Sirtuin‐1 (Sirt1), a member of the NAD‐dependent sirtuin family of histone/protein deacetylases (HDAC), is an important target for immunotherapy due to its role in deacetylating the transcription factors Foxp3 and thymic retinoid acid receptor related orphan receptor gamma (RORγt). Sirt1 inhibition can increase Foxp3 acetylation and promote the production and functions of Foxp3+ T‐regulatory (Treg) cells, whereas the acetylation of RORγt decreases its transcriptional activity DNA binding and decreases the differentiation of proinflammatory Th17 cells. Pharmacologic inhibitors of Sirt1 increase allograft survival and decrease autoimmune colitis and experimental allergic encephalomyelitis. However, in contrast to its role in T cells, Sirt1 has anti‐inflammatory effects in myeloid cells, and, context dependent, in Th17 cells. Here, inhibition of Sirt1 can have proinflammatory effects. In addition to effects arising from the central role of Sirt1 in cellular metabolism and NAD‐dependent reactions, such proinflammatory effects further complicate the potential of Sirt1 for therapeutic immunosuppression. This review aims to reconcile the opposing literature on pro‐ and anti‐inflammatory effects of Sirt1, provides an overview of the role of Sir1 in the immune system, and discusses the pros and cons associated with inhibiting Sirt1 for control of inflammation and immune responses.

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Role of Histone Deacetylases in Monocyte Function in Health and Chronic Inflammatory Diseases

Tordera

Cortés-Erice

2021

Reviews of Physiology, Biochemistry and Pharmacology

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NAD + dependent deacetylase Sirtuin 5 rescues the innate inflammatory response of endotoxin tolerant macrophages by promoting acetylation of p65

Cited by 55 publications

References 39 publications

Cloning, expression profiling, and acetylation identification of alpha‐tubulin N‐acetyltransferase 1 from Bombyx mori

Cloning, expression profiling, and acetylation identification of alpha‐tubulin N‐acetyltransferase 1 from Bombyx mori

Sirtuin-1 in immunotherapy: A Janus-headed target

Role of Histone Deacetylases in Monocyte Function in Health and Chronic Inflammatory Diseases

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