Nacre-inspired magnetically oriented micro-cellulose fibres/nano-hydroxyapatite/chitosan layered scaffold enhances pro-osteogenesis and angiogenesis

Silane-modified hydroxyapatite nanoparticles incorporated into polydioxanone/poly(lactide-co-caprolactone) creates a novel toughened nanocomposite with improved material properties and in vivo inflammatory responses

“…Bone histomorphometry at 6 weeks revealed a significant amount of de novo bone matrix formation in a rabbit model [ 19 ]. Recently, the oriented microcellulose fibres containing nano-hydroxyapatite is prepared by mimicking the extracellular matrix of bone tissue [ 20 ]. The nano-hydroxyapatite was deposited on the surface of cellulose fibres, and then the magnetic nanoparticles on the cellulose fibres were aligned on the surface of chitosan under a magnetic field.…”

“…The nano-hydroxyapatite was deposited on the surface of cellulose fibres, and then the magnetic nanoparticles on the cellulose fibres were aligned on the surface of chitosan under a magnetic field. The oriented microcellulose fibres promoted the high expression of collagen type I, and consequently, formed new blood vessels [ 20 ].…”

Application of Nanocellulose-Based Aerogels in Bone Tissue Engineering: Current Trends and Outlooks

“…According to research findings, it has been demonstrated that n–HA was deposited on the surface of CNF, and magnetic nanoparticles on the CNF were oriented on the surface of chitosan under the action of a magnetic field. The oriented cellulose fibers enhance the compressive properties of the scaffold, while the n–HA on the oriented cellulose fiber surface promotes the formation of new blood vessels and accelerates chondrogenesis, ultimately guiding bone growth orientation and promoting bone activity [ 161 ] ( Figure 4 B,C). Ultrasound has emerged as a promising tool in the field of tissue engineering due to its capacity to modulate cellular behavior, enhance cell proliferation and migration, and induce changes in extracellular matrix production.…”

“…[ 157 ] Copyright 2020 Elsevier. ( B ) ALP activity and Alizarin Red staining showing that magnetic-oriented CS–cellulose promoted BMSC osteogenic differentiation and adhesion [ 161 ]. Copyright 2022 Elsevier.…”

“…Copyright 2022 Elsevier. ( C ) Micro-CT demonstrated that magnetic-oriented CS–cellulose significantly facilitated the healing of cranial bone defect, [ 161 ]. Copyright 2022 Elsevier.…”