Silane-modified hydroxyapatite nanoparticles incorporated into polydioxanone/poly(lactide-co-caprolactone) creates a novel toughened nanocomposite with improved material properties and in vivo inflammatory responses

Shiroud Heidari, Behzad; Lopez, Emma Muinos; Chen, Peilin; Ruan, Rui; Vahabli, Ebrahim; Davachi, Seyed Mohammad; Granero-Moltó, Froilán; De-Juan-Pardo, Elena M.; Zheng, Minghao; Doyle, Barry

doi:10.1016/j.mtbio.2023.100778

Cited by 6 publications

(1 citation statement)

References 80 publications

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“…The hydrophilicity of the DI nanoparticles was dependent on the presence of the hydroxyl groups, which were reduced in the modified DI due to the GPTMS treatment, where silane functional groups were bonded with the hydroxyl groups instead. Similar observations were noticed in previous studies where nanoparticles were modified with silane coupling agents and incorporated into the polymer matrix …”

Section: Resultssupporting

confidence: 90%

Surface-Modified Diopside-Reinforced PCL Biopolymer Composites with Enhanced Interfacial Strength and Mechanical Properties for Orthopedic Applications

Ghosh,

Gupta,

Mehrotra

et al. 2024

ACS Appl. Mater. Interfaces

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The phase separation of ceramics in a biopolymer matrix makes it challenging to achieve satisfactory mechanical properties required for orthopedic applications. It has been found that silane coupling agents can modify the surface of the bioceramic phase by forming a molecular bridge between the polymer and the ceramic, resulting in improved interfacial strength and adhesion. Therefore, in the present study, silane-modified diopside (DI) ceramic and ε-polycaprolactone (PCL) biopolymer composites were fabricated by injection molding method. The silane modification of DI resulted in their uniform dispersion in the PCL matrix, whereas agglomeration was found in composites containing unmodified DI. The thermal stability of the silane-modified DI-containing composites also increased. The Young’s modulus of the composite containing 50% w/w DI modified by 3% w/w silane increased by 103% compared to composites containing 50% w/w unmodified DI. The biodegradation of the unmodified composites was significantly high, indicating their weak interfacial strength with the PCL matrix (p ≤ 0.001). The osteoconductive behavior of the composites was also validated by in vitro cell–material studies. Overall, our findings supported that the silane-modified composites have improved surface roughness, mechanical, and osteoconductive properties compared to the unmodified composite and have the potential for orthopedic applications.

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Section: Resultssupporting

confidence: 90%

Surface-Modified Diopside-Reinforced PCL Biopolymer Composites with Enhanced Interfacial Strength and Mechanical Properties for Orthopedic Applications

Ghosh,

Gupta,

Mehrotra

et al. 2024

ACS Appl. Mater. Interfaces

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Modulation of mechanical and thermal properties of poly(lactic acid)/hydroxyapatite composites by interface crosslinking

Odabaş,

Öztürk,

Akarsu

2024

Polymer Composites

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Poly(lactic acid) (PLA) is a biodegradable and bioactive thermoplastic polymer. It has been widely used for hard tissue applications in orthopedic and dental fields. However, PLA is not able to form a direct bond with bone and this limits its applications. Therefore, PLA and hydroxyapatite (HAp) composites have gained significant attention to improve PLA performance. However, agglomeration of HAp in PLA matrix due to unfavored interfacial interactions between PLA and HAp directly affects the mechanical properties and stability of PLA/HAp composites. In this study, 3‐(glycidyloxypropyl)trimethoxysilane (GLYMO)‐modified HAp particles (G‐HAp) were synthesized and then incorporated into the PLA matrix to prepare PLA/G‐HAp composites. PLA/G‐HAp composites were prepared by mixing G‐HAp at 50 wt% with PLA (10 wt% in chloroform) solution. The resulting mixture was dried, ground, and molded into cylindrical shapes by pressure, and cured under N2 atmosphere. The interface interactions of the obtained composites were elucidated by fourier transform infrared spectrometer (FTIR), scanning electron microscopy (SEM) and atomic force microscopy (AFM) analyses. It was observed that increased crosslinking density in the interface resulted in rougher surfaces. Thermal analyses demonstrated that Tg of PLA shifted to higher temperatures in parallel with crosslinking density. Additionally, Vicker's hardness tests and compression tests were conducted to determine the effect of interfacial crosslinking, and improved hardness and Young's modulus were observed. In the final part of study, MTT assay was carried out to evaluate cytotoxicity of composites and PLA/G‐HAp displayed higher cytocompatibility compared to conventional PLA/HAp composite.Highlights GLYMO modified HAp led to changes in the surface properties of composites. Increased crosslinking caused rougher surfaces for composites. Tg shifted to higher temperatures in parallel with GLYMO mediated crosslinking. Composites containing GLYMO‐modified HAp particles exhibited significant improvement in mechanical properties.

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Design of monolithic superhydrophobic concrete with excellent anti-corrosion and self-cleaning properties

Cui,

Xiang,

et al. 2024

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Silane-modified hydroxyapatite nanoparticles incorporated into polydioxanone/poly(lactide-co-caprolactone) creates a novel toughened nanocomposite with improved material properties and in vivo inflammatory responses

Cited by 6 publications

References 80 publications

Surface-Modified Diopside-Reinforced PCL Biopolymer Composites with Enhanced Interfacial Strength and Mechanical Properties for Orthopedic Applications

Surface-Modified Diopside-Reinforced PCL Biopolymer Composites with Enhanced Interfacial Strength and Mechanical Properties for Orthopedic Applications

Modulation of mechanical and thermal properties of poly(lactic acid)/hydroxyapatite composites by interface crosslinking

Design of monolithic superhydrophobic concrete with excellent anti-corrosion and self-cleaning properties

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