NaBH₄ Reduction of Ketones in the Solid State

An atom efficient, green synthesis of 2-pyrazoline derivatives under solvent-free conditions using grinding technique

“…The grinding mode for solid-state reactions has been reported for some well-known reactions such as Grignard reactions (14), Reformatsky reactions (15), Aldol condensations (16), Dieckmann condensations (17), Knoevenagel condensations (18), Reductions (19), and others (20,21). Most of these reactions are carried out at room temperature in absence of solvent-free environment, using only a mortar and pestle.…”

Enantioselective synthesis of a taxol C ring

“…(4aS,5S)-5-Hydroxy-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one (9) 8 Acetic acid (50 µl), hydroquinone (1.8 mg, 0.16 mmol, 0.02 equiv.) and freshly distilled methyl vinyl ketone (2.2 g, 32 mmol, 2.0 equiv.)…”

TADDOL and Its Derivatives – Our Dream of Universal Chiral Auxiliaries

“…There are several more reactions of this type, described in the literature [54], and the Toda group has determined the crystal structures of a number of inclusion compounds to show the correlation between the crystal packing and the configuration of the photoproducts. Diastereoselective solid-phase reactions of chiral guests in TADDOL-host lattices have also been described by the Toda group [55]. in these reactions.…”