Na+/K+ATPase Activity in Sheep with Natural Babesiosis

Yur, Fatmagül; Yazar, Mete; Değer, Yeter; Dede, Semiha

doi:10.2754/avb201079020233

Cited by 3 publications

(6 citation statements)

References 25 publications

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“…2) A decline in Na + /K + ATPase activity in the cell membrane. PachccoRosado et al 25 and Carageorgiou et al 26 described a decrease in hippocampus Na + /K + ATPase activity in hypothyroid rats and Yur et al 2 reported Na + /K + ATPase activity decreases in sheep naturally infected with babesiosis. It is likely that decreased levels of Na + /K + ATPase activity would have been observed in the animals studied here, eventually resulting in lipid peroxidation via unknown mechanism(s).…”

Section: Discussionmentioning

confidence: 99%

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Babesiosisli Koyunlarda Plazma Malondialdehid, Tiroid Hormonları ve Bazı Kan Profilleri

Azimzadeh¹,

Nouri²,

Farooghi³

et al. 2013

Kafkas Univ Vet Fak Derg

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Section: Discussionmentioning

confidence: 99%

“… İletişim (Correspondence)  +98 441 3476434  kn_az@yahoo.com which is characterized by fever, anemia, icterus and hemoglobinuria 1,2 . B. ovis has been observed in most regions of Iran 1 .…”

Section: Introductionmentioning

confidence: 99%

Babesiosisli Koyunlarda Plazma Malondialdehid, Tiroid Hormonları ve Bazı Kan Profilleri

Azimzadeh¹,

Nouri²,

Farooghi³

et al. 2013

Kafkas Univ Vet Fak Derg

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“…Babesia ovis induces the expression of severe pathogenic traits in sheep and causes sheep babesiosis, which is characterized by fever, anemia, icterus and hemoglobinuria (1,2). B. ovis has been observed in most regions of Iran (1).…”

Section: Introductionmentioning

confidence: 99%

Koyun Babeziozisinde Plazma Arginaz, Gelsolin ve Sistatin C Arasında Olası Potansiyel Biyobelirteç Tayini: Parazitemi Oranına Göre

Azimzadeh

Mahan

Hergalani³

et al. 2019

Atatürk Üniversitesi Veteriner Bilimleri Dergisi

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The aim of this study was to assay arginase activity, gelsolin (GLS) and cystatin c (Cys c) levels and determination of potential biomarker in sheep babesiosis. The Babesia genus as pathogen blood parasites causes economic problems in livestock management. Many published studies have suggested babesiosis-induced biochemical parameters, but no one have determined those parameters alterations and clarification of sensitivity and specificity. Sheep with acute babesiosis were identified based on clinical signs and the observation of Piroplasm forms in red blood cells. After blood sampling from 25 infected and same number healthy sheep, above parameters measured in plasma. The results indicated significant increase (P<0.01) in arginase and Cys c and significant decreases (P<0.01) in the levels of GLS in different parasitemia rates compared with healthy group. In conclusion, the results suggested that sheep babesiosis causes cellular damage especially in kidney (owing to high level of Cys c) and high arginase activity can be considered as one of essential factor in Babesia ovis proliferation process. Finally, high sensitivity of Cys c and arginase in the different parasitemia rates than GLS could be clarified as potential biomarker of sheep babesiosis.

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“…Two species, Babesia ovis and Babesia sp. Xinjiang, are highly pathogenic, especially in sheep, and cause severe infections characterized by fever, anemia, icterus, and hemoglobinuria (1)(2)(3)(4). Babesia species can cause severe economic losses in sheep and goats, particularly in tropical and subtropical climates.…”

Section: Introductionmentioning

confidence: 99%

“…Intraerythrocytic parasites, such as Babesia and Plasmodium, are thought to produce hemolytic effects by oxidative stress and increased lipid peroxidation. Invasions of parasites demolish hematopoiesis and thus cause anemia (2,6), which is defined as a reduction in the number of erythrocytes and/ or a subnormal concentration of hemoglobin per unit volume of blood. The decrease in red cell mass results in reduced oxygen transport and may lead to tissue hypoxia and hemodynamic and nonhemodynamic compensatory events.…”

Section: Introductionmentioning

confidence: 99%

Determination of serum cardiac biomarkers and plasma D-dimer levelsin anemic sheep with babesiosis

KILINÇ¹,

GÖZ²,

YÜKSEK³

et al. 2015

Turk J Vet Anim Sci

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In this study, the cardiac effects of anemia and venous thromboembolism (VTE), reportedly caused by the hemolyzed erythrocytes occurring in sheep with babesiosis, were investigated using cardiac markers and D-dimer (DD). The study included 34 sheep: 24 infected Akkaraman sheep (1-3 years old, diagnosed with babesiosis based on clinical and laboratory findings) and a control group of 10 noninfected healthy sheep of the same breed and age. Hematocrit (Hct) levels were measured in blood obtained from both groups. Cardiac troponin I (cTnI), creatine kinase-MB (CK-MB), and aspartate aminotransferase (AST) levels were measured in serum samples. In addition, the levels of DD were also measured in plasma samples. Sheep with babesiosis were subsequently divided into 3 subgroups according to their Hct levels, which ranged from 13.2% to 16.3% in the first group (n = 8), 20.1% to 25.6% in the second group (n = 8), and 27.4% to 30.3% in the third group (n = 8). Evaluations of the measurements of cTnI, CK-MB, and AST levels indicated statistically significant differences between infected and healthy sheep. Statistically significant differences were not found for DD levels between the 2 groups.

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Na+/K+ATPase Activity in Sheep with Natural Babesiosis

Cited by 3 publications

References 25 publications

Babesiosisli Koyunlarda Plazma Malondialdehid, Tiroid Hormonları ve Bazı Kan Profilleri

Babesiosisli Koyunlarda Plazma Malondialdehid, Tiroid Hormonları ve Bazı Kan Profilleri

Koyun Babeziozisinde Plazma Arginaz, Gelsolin ve Sistatin C Arasında Olası Potansiyel Biyobelirteç Tayini: Parazitemi Oranına Göre

Determination of serum cardiac biomarkers and plasma D-dimer levelsin anemic sheep with babesiosis

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