Na+-Glucose Cotransporter Inhibitors as Antidiabetic Agents. II. Synthesis and Structure-Activity Relationships of 4'-Dehydroxyphlorizin Derivatives.

Preventive Effects of Flavonoids on Alloxan-Induced Diabetes Mellitus in Rats

“…There is no report on the glycosuric effect of both flavonoids in the literature and we can currently only speculate about it. It is concluded that some flavonoids or plant extracts with a high content of flavonoids may cause potent inhibition of renal glucose reabsorption through inhibition of the sodium-glucose symporters located in the proximal renal tubule (Hongu et al 1998;Maghrani et al 2005).…”

Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitors for New Anti-Diabetic Agent

“…In modification of the B ring, 4´-Me or 4´-Et derivatives enhanced UGE compared with 4´-dehydroxy derivative. On the other hand, the exchange of 6´-OH to 6´-H or 6´-alkoxy led to complete loss or decrease of the activity [19,31,32]. The most potent compound (3) is anticipated to be hydrolyzed by -glucosidase in the digestive tract.…”

Sodium-dependent glucose transporter protein as a potential therapeutic target for improving glycemic control in diabetes

“…SGLT proteins were first postulated as a possible therapeutic target for the control of blood glucose levels in 1996 by Tsujihara et al 5 These investigators, along with Hongu et al, described the possibility of using SGLT inhibitors as antidiabetic agents on the basis of experimental studies in rats. [5][6][7] Since then, regulation of glucose disposal through SGLT proteins has been considered an important biological target that can be used for the development of innovative therapies to effectively manage diabetes and prevent its long-term complications. 8 The objective of this manuscript is to review the role of SGLT proteins in the pathophysiology of diabetes and to describe the mechanisms by which these transporters may be used for glycemic control and treatment of diabetes.…”