Preventive Effects of Flavonoids on Alloxan-Induced Diabetes Mellitus in Rats

Lukačínová, Agnesa; Mojžiš, Ján; Benacka, R; Keller, Jeffrey N.; Maguth, T.; Kurila, P.; Vaško, Ladislav; Rácz, Olivér; Nistiar, F

doi:10.2754/avb200877020175

Cited by 69 publications

(54 citation statements)

References 29 publications

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“…It is also found in mushrooms, honey and propolis in an edible form. It has also been reported to possess anti‐oxidant, 10 antidiabetogenic, 11 anticancerous, 12 anti‐estrogenic 13 and anxiolytic 14 properties. The present study is designed to investigate the putative anti‐aging effect of chrysin in d ‐galactose‐induced aging in an experimental rat model.…”

Section: Introductionmentioning

confidence: 99%

Protective role of chrysin against oxidative stress in d‐galactose‐induced aging in an experimental rat model

Anand

Jaabir

Thomas

et al. 2012

Geriatrics Gerontology Int

104

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Section: Introductionmentioning

confidence: 99%

Protective role of chrysin against oxidative stress in d‐galactose‐induced aging in an experimental rat model

Anand

Jaabir

Thomas

et al. 2012

Geriatrics Gerontology Int

104

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“…Flavonoids also inhibit ROS formation by suppressing the action of some enzymes that produce it (Lukacinova et al, 2008). As a potential antioxidant, the flavonoid chains the metal and stabilizes it so that it can not catalyze the free radical oxidation reaction (Song et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Effects of Bean Ethanol Extract (Phaseolus Vulgaris L.) on Superoxide Dismutase Activity in Wistar Mice (Micetus Norvegicus) Hyperglycemia

Sinaga¹,

Anggraini²

2017

INDONES J MED

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Background: Aloxan tetrahyd micee causes free radicals and higher reactive oxidative species (ROS) production, being able to lead to reduce insulin secretion from pancreatic β cells and receptor sensitivity in insulin-receptor cells resulting in hyperglycemia conditions. Bean extract ethanol can reduce oxidative stress. The purpose of this study was to determine bean's ethanol extract effectiveness in lowering blood sugar levels and increasing the activity of superoxide dismutase (SOD) enzyme. Subjects and Methods: This was a randomized controlled trial (RCT) study. The samples were mice (Micetus norvegicus) of wistar strains randomized in five groups: P1-negative control, positive P2-control, P-3 ethanol extract group of 200mg / kgBW, P4-group 400mg / kgBW, P5-group 600 mg / kgBW. Dependent variables are blood sugar (mg/ dL) and superoxide dismutase enzymes. The independent variable is the bean extract of ethanol. Differences in blood sugar levels and superoxide enzyme levels of intergroup dismutase were tested by Anova test, followed by post hoc test, to determine the effectiveness of bean extract ethanol. Results: This study showed a statistically significant decrease in blood glucose levels after ethanol extract of green beans 600 mg / kg BW from day 14 to day 28 (p <0.05). This study did not show a decrease in blood sugar levels after ethanol extract of green beans 200 mg / kgBW and 400 mg / kgBW from day 7 until day 28 (p> 0.05). Giving ethanol extract of green beans did not affect the activity of superoxide dismutase enzyme (p = 0.830). Conclusion: Giving ethanol extract of green beans 600 mg / kgBW effectively decrease blood sugar in male wistar mice (Micetus norvegicus) from day 14 to day 28. Giving ethanol extract of green beans 200 mg/ kgBW, 400 mg / kgBW, and 600 mg / kgBW, is not effective to increase the activity of superoxide dismutase enzyme.

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“…Animals were fed normal chow diet and ad libitum under controlled environmental condition of temperature (24-28°C), relative humidity 60-70% and natural light/dark cycle (12:12). 17 Both extracts were administered in experimental animals for 7 days with different doses (100, 200 and 400 mg/kg) and serum was separated with centrifugation at a speed of 3000 rpm for 10 min. The level of reduced glutathione and catalase was measured in serum.…”

Section: Animalsmentioning

confidence: 99%

Antioxidant and Anti-hypercholesterolemic potential of Vitis vinifera leaves

Devi¹,

Singh²

2017

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Background: Grapes (Vitis vinifera) are universally appreciated fruit for their delicacy, nutrition and accepted as functional food. The objective of the present study is to evaluate antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves extract. Methods: Qualitative and quantitative phytochemical screening of methanolic (VVME) and aqueous (VVAE) extract was carried out to identify the phytoconstituents. Antioxidant potential was evaluated by employing in-vitro and in vivo assays. The anti-hypercholesterolemic activity was evaluated by inducing hypercholesterolemia with high cholesterol diet for 21 days in experimental animals. Results: In VVME, total tannins, total flavonoids and total phenolic contents were found to be present in major amount. Both extract has significant in-vitro and in-vivo antioxidant efficacy. Different doses i.e. 100, 200 and 400 mg/kg of VVME and VVAE significantly attenuated the lipid levels. Moreover, VVME was found to be more effective as compared to VVAE and also, effectiveness was confirmed with histological results. Conclusion: It can be concluded that antioxidant and anti-hypercholesterolemic efficacy of Vitis vinifera might be due to presence of antioxidant property and active phytoconstituents.

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Preventive Effects of Flavonoids on Alloxan-Induced Diabetes Mellitus in Rats

Abstract: Lukačínová A.,

Cited by 69 publications

References 29 publications

Protective role of chrysin against oxidative stress in d‐galactose‐induced aging in an experimental rat model

Protective role of chrysin against oxidative stress in d‐galactose‐induced aging in an experimental rat model

Effects of Bean Ethanol Extract (Phaseolus Vulgaris L.) on Superoxide Dismutase Activity in Wistar Mice (Micetus Norvegicus) Hyperglycemia

Antioxidant and Anti-hypercholesterolemic potential of Vitis vinifera leaves

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