2019
DOI: 10.1038/s41588-019-0549-x
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N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells

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Cited by 157 publications
(128 citation statements)
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“…3b and Extended Data Fig. 6a,b), we found that a significant number of METTL3-dependent m 6 A events mapped to retrotransposon annotations, comprising 13% of all peaks, including L1s—as previously reported 25,26 —and ERVK elements (Fig. 3b).…”
Section: Main Textsupporting
confidence: 82%
“…3b and Extended Data Fig. 6a,b), we found that a significant number of METTL3-dependent m 6 A events mapped to retrotransposon annotations, comprising 13% of all peaks, including L1s—as previously reported 25,26 —and ERVK elements (Fig. 3b).…”
Section: Main Textsupporting
confidence: 82%
“…While this work used normally cultured, unperturbed human cells, many studies have used S9.6-based imaging to measure changes in RNA:DNA hybrid content under various experimental conditions. An array of gene perturbations and drug treatments have been reported to cause changes in S9.6 IF signal attributed to altered R-loop metabolism or RNA:DNA hybrid levels [8,30,[34][35][36][47][48][49][50]. Many of the genes that have been ascribed roles in R-loop regulation participate in diverse RNA metabolic processes like transcription, RNA splicing, RNA processing, and RNA export [6].…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, m 6 A has been shown to be present on RNA:DNA hybrids [ 136 , 137 ]. Abakir et al have shown that m 6 A can coordinate R-loop removal with the m 6 A reader, YTH-domain family member 2 (YTHDF2), contributing to genome stability [ 136 , 138 ]. Interestingly, this m 6 A modification of R-loops is not constitutive, but rather is cell cycle dependent.…”
Section: Looking Ahead: Rna Modifications and The Ddr A Role For Rnamentioning
confidence: 99%
“…Interestingly, this m 6 A modification of R-loops is not constitutive, but rather is cell cycle dependent. m 6 A is present on R-loops in S and G 2 /M phases of the cell cycle, and is reduced in the G 0 /G 1 phases of the cell cycle [ 136 , 138 ]. It is not yet clear if this could impact the DDR, in particular the DSB response, but given the known role of R-loops in DSB repair [ 63 , 100 , 111 ], it implicates a further possible role for m 6 A in the cellular DDR.…”
Section: Looking Ahead: Rna Modifications and The Ddr A Role For Rnamentioning
confidence: 99%