“…While it has long been known that the processing and transport of protein-coding mRNAs is crucial for the DSB response (Wickramasinghe and Venkitaraman, 2016), long and short non-coding RNAs have only recently been identified as direct regulators of this pathway. Indeed, the last years have seen the identification of an evergrowing network of diverse non-coding RNA species that locally modulate DSB signaling and repair (Mikolaskova et al, 2018;Bader et al, 2020;Ketley and Gullerova, 2020). Not surprisingly, the RNA network surrounding the DSB response is tightly associated with RNA-binding proteins (RBPs), many of which are themselves subject to DNA damage-induced PTMs (Matsuoka et al, 2007;Paulsen et al, 2009;Bensimon et al, 2010;Hurov et al, 2010;Słabicki et al, 2010;Adamson et al, 2012;Beli et al, 2012;Izhar et al, 2015;Shkreta and Chabot, 2015).…”