N6-Furfuryladenine, Kinetin, Protects against Fenton Reaction-Mediated Oxidative Damage to DNA

Kinetin—A multiactive molecule

“…It protects (p < 0.005) DNA against oxidative damage to 8-oxo-dG mediated by the Fenton reaction. Kinetin inhibits 8-oxo-dG formation in a dose-dependent manner with a maximum of 50% protection observed at 100 M kinetin [38]. At 50 M was more efficient (82% inhibition) than adenine (49% inhibition) in the inhibition of bovine serum albumin (BSA)-pentosidine formation in slow and fast glycation/glycoxidation models of protein damage.…”

Kinetin Inhibits Protein Oxidation and Glycoxidation in Vitro

“…Previously, we have shown that kinetin is able to inhibit the Fenton-reaction mediated formation of 8-oxo-dG in the DNA (6).…”

“…Although the exact mechanisms of action of kinetin are not fully known, it has been suggested to act both as an inhibitor of the radical oxygen species (ROS) formation and as a scavenger of ROS (1). It prevents the oxidation of unsaturated fatty acids (5) and inhibits the in vitro formation of 8-oxo-2Ј-deoxyguanosine (8-oxo-dG) in DNA (6). Considering the anti-oxidative effects of kinetin on fatty acids and DNA, we examined whether kinetin also protects against protein oxidation and glycoxidation.…”

Novel anti-aging composition for topical skin care

“…It is a naturally occurring plant growth factor that retards senescence in plants and has been found to have anti-aging effects on human adult skin fibroblasts in vitro (Barciszewski et al 1999;Rattan and Clark 1994). Kinetin appears to be both a direct anti-oxidant and a signaling molecule that stimulates the maintenance and repair pathways in cells (Olsen et al 1999;Verbeke et al 2000). Extended treatment with kinetin was well tolerated and did not cause irritation.…”